Selected Talks

The main links are to the presentations embedded in Google Drive.  Because some websites block Google Drive, links in GitHub (denoted <github>) are also provided.

TUTORIALS

• Fundamental Concepts of PKPD

  • Introduction to Fundamental PK Concepts <github> (from 2018-2019 Novartis Academia-Industry Quantitative Hackathon)

  • Introduction to Fundamental PD Concepts <github> (from 2018-2019 Novartis Academia-Industry Quantitative Hackathon)

  • Causal Diagrams for Exposure-Response Analysis <github> for when correlation doesn't imply causation (from 2021 Novartis Academia-Industry Quantitative Hackathon)

• Model Uncertainty and Identifiability

  • Assessing the Uncertainty and Predictive Accuracy of Mechanistic Models; with Applications in CML [YouTube Video] <github> (FDA Systems Pharmacology Group Meeting 2020, Laboratory for Systems Medicine at University of Florida Group Meeting 2022) 

  • Importance of Assessing Model Convergence and Practical Identifiability During Model Development <github> (ACoP 2018)

ONCOLOGY

• • CAR-T cells

    • Chimeric Antigen Receptor T cell Therapies: A Review of Cellular Kinetic-Pharmacodynamic Modeling Approaches <github> (ACoP 2021)

    • The Cellular Kinetics and Anti-Tumor Dynamics of Kymriah <github> (ACoP 2019)

  • Solid Tumor Modeling

    • Using Longitudinal Solid Tumor Data to Improve Drug Development Decisions <github> (ACoP 2013)

    • Dose Selection in Solid Tumor Trials: Making use of All Available Data <github> (PhUSE 2013)

  • Chronic Myeloid Leukemia (CML)

    • Bcr-Abl Kinetics Suggests that Self Renewing Leukemic Cells are Reduced During Imatinib Treatment <github> (ASH 2009)

BIOLOGICS

• • Assessing the Identifiability of Models for Target Mediated Drug Disposition using a New Metric of Potency <github> (SIAM Life Sciences 2016)

  • Two New Parameters for Characterizing Ligand Binding Systems <github> (ACoP 2017)