Who we are...

Hugo Aguilaniu's laboratory works on the genetics of ageing using C. elegans as a model system. More specifically, our goal is to identify the molecular links between lifespan, reproduction and nutrition. Reducing food intake or ablating the germline trigger metabolic programs that lead to extended lifespan. Although proximal processes involved are actively being identified, the biology of aging is still largely obscure. In other words, we still fail to understand whether ageing is regulated and/or to what extent lifespan contribute to fitness. We believe that this can only be achieved by assessing the links between lifespan and other traits known to contribute to fitness at the molecular level and in various conditions. We hope that our research will ultimately lead to new strategies to treat age-related diseases such as cancer, neurodegeneration, metabolic syndromes and sarcopenia.

We are still located at the Institut de Génomique Fonctionelle de Lyon which belongs to the Ecole normale supérieure de Lyon and we are affiliated to the CNRS until the end of 2017. We will then be moving to Rio de Janeiro where H. Aguilaniu assumed the presidency of the Serrapilheira Institute. Of course, the lab will continue...