Clinical Trials

Clinical research helps improve our understanding of PPROM, pregnancy care, premature birth, and long-term outcomes.

Some studies test medications, diagnostic tools, or other interventions. Others are observational and collect information about pregnancy experiences, treatment, or outcomes.

Participation in research is always voluntary.

Find a Clinical Trial

ClinicalTrials.gov

ClinicalTrials.gov is the U.S. National Library of Medicine's searchable database of clinical research studies.

You can search for studies using terms such as:

• PPROM

• Preterm Premature Rupture of Membranes

• Premature Rupture of Membranes

• Oligohydramnios

• Preterm Birth

Search results can be filtered by location, recruitment status, age, and other study characteristics.

Search ClinicalTrials.gov

Learn How to Search ClinicalTrials.gov

International Clinical Trials

The World Health Organization International Clinical Trials Registry Platform (ICTRP) provides access to clinical trial records from registries around the world.

This may be especially useful for families or researchers looking for studies outside the United States.

Search the WHO International Clinical Trials Registry Platform

Before Joining a Study

Every clinical study has its own purpose and eligibility requirements.

If you are considering participating, you may want to ask the research team:

• What is the purpose of the study?

• What would participation involve?

• Why might I be eligible?

• Are there potential risks or benefits?

• Will participation affect my current medical care?

• Are there costs associated with participating?

• Will travel be required?

• How will my information be protected?

• Can I stop participating if I change my mind?

• Who should I contact if I have questions?

Your healthcare provider can also help you understand how participation may relate to your individual pregnancy or medical care.

Understanding Study Status

Clinical trial listings may use terms such as:

Recruiting: The study is currently enrolling participants.

Not Yet Recruiting: The study is registered but enrollment has not started.

Active, Not Recruiting: The study is ongoing but is no longer enrolling new participants.

Completed: The study has ended.

Always check the individual study listing for its most recent recruitment status, locations, and contact information.

The PPROM Registry

The PPROM Foundation also maintains the PPROM Patient Registry, a patient-reported outcomes research study focused specifically on pregnancies affected by PPROM.

The Registry is an observational study and does not provide or test a medical treatment.

Learn More About the PPROM Registry

View the PPROM Registry on ClinicalTrials.gov

For Researchers

Researchers interested in working with The PPROM Foundation should visit our research information page for details about research collaboration and study recruitment.

Research With The PPROM Foundation

The PPROM Foundation provides links to clinical trial registries for informational purposes. Listing or linking to a study does not mean that The PPROM Foundation endorses the study, its investigators, or the treatment being studied.

Patients should discuss participation in clinical research with the study team and their own healthcare providers.

The PPROM Foundation does not endorse, promote, or manage the studies / trials listed above.