Emily Hong
Epidemiology of Hong Kong's 2003 SARS Outbreak
Epidemiology of Hong Kong's 2003 SARS Outbreak
Hi everyone! Welcome to my Advanced Biology DYO website! Here is a video abstract that hopefully can concisely describe what I've been spending the last month on in Advanced Bio!! Enjoy :)
About Hong Kong
With an area of just 427 square miles, Hong Kong sits on the border of southern China, with over 7.5 million people calling the city home. With its proximity to both China and the ocean, Hong Kong serves not only as an international trade hub but a popular tourist destination for those in and out of China. Notably, Hong Kong shares a border with Shenzhen, one of the largest cities in the Guangdong (Canton) province. In Hong Kong’s natural landscape, mountains, oceans, and beaches are scattered throughout. The city’s primary language is Cantonese, though English is widely understood after the city’s temporary takeover by Britain from the mid-19th to late-20th century.
Severe acute respiratory syndrome, also known as SARS, was a highly transmittable respiratory disease that prowled its way around Hong Kong in spring of 2003, then later other countries in Asia and even Canada. With a basic reproduction number (R0) estimated to be 2.1 and a mean incubation period of 6.37 days, the disease spread easily among residents primarily through coming in contact with droplets, though a large percentage of cases was also passed through food packagers and food workers. In the course of its run, SARS infected upward of 1700 people in Hong Kong, leaving nearly 300 dead.
I reached out to a bunch of friends from Hong Kong and asked them about their opinions, experiences, or general thoughts about the Hong Kong 2003 SARS epidemic. Here are some of their stories!
(HUGE Thank you to Participants: Allan Guo, Kirsten Ting, Talia Kriegal, Kirsten Lai, Reika Nakagawa, Bethany Winter, Pankhuri Dayal, and Daryn Wong)
SARS-CoV, which is a coronavirus closely related to group II coronaviruses such as human virus OC43 and mouse hepatitis virus, was responsible for the SARS disease that spread across Hong Kong in 2003. The SARS-CoV viral genome consists of 29,727 nucleotides forming a single-stranded RNA with 14 functional open reading frames (ORFS). Out of these ORFs, 2 pertain to the replicase gene which encodes for the proteins needed for viral RNA synthesis processes.
In 2002, Hong Kong celebrated its five year anniversary from its return to China from British reign. In 2003, not quite a year afterwards, the densely populated city was thrust into its worst epidemic of the century. During the short few months of SARS’ reign over the city, over 1700 people were infected with the disease, nearly 300 of whom were killed. With no confirmed cure in place, residents of Hong Kong (and other countries with people afflicted with SARS) had to resort to preventative measures as the government struggled to keep public trust levels sustained.
My project focused on studying the epidemiology of SARS. Epidemiology, which is a branch of medicine, dives into analyzing and understanding health conditions and disease through various lenses such as distribution of resources, prevention of disease, and patterns and determinants of health conditions. For my DYO project specifically, I sought out to learn as much as I could about the SARS disease that affected Hong Kong, a place I call home.
A main reason why I chose this topic in the first place was due to the importance of the SARS epidemic to the city of Hong Kong. Personally, I was lucky enough to have been born in the United States when SARS was happening in Hong Kong, but even though I moved to Hong Kong after the epidemic had long faded, the imprints that it has left on Hong Kong society still remain. In the video of some of my friends for Hong Kong, for example, Kirsten spoke of how her grade was constantly smaller than others due to parents’ unwillingness to bring a child into the world during SARS. Talia, on the other hand, spoke of her family’s being separated so that her mother could safely bring her into the world outside of Hong Kong. While people in Hong Kong were affected in different ways, it is clear that SARS has been plenty influential.
Figure #1: Graph shows cases over time including two primary peaks (PWH and Amoy Gardens). Brief late March/early April peak was caused by a spike in cases among healthcare workers.
Source: Lee Shiu Hung, JRSM
SARS’ categorization as a coronavirus conveniently aligned with COVID-19, which is caused by SARS-CoV2. The similarity between the two coronaviruses and diseases meant that at least some of the information I was reading about in my research project, I had learned over the course of the pandemic. One really interesting thing I learned, however, was how SARS entered Hong Kong in the first place, and its distant but existing parallel to COVID-19.
In late February of 2003, a medical professor from Guangzhou visited Hong Kong, staying in room 911 (now removed due to the stigma) of the Metropark Hotel Kowloon, then known as the Metropole Hotel. Unbeknownst to him, he had been afflicted with SARS, likely from the outbreak sparked in a major teaching hospital in Guangzhou, the city where the professor was from. The Metropole hotel outbreak infected 12 people, some of whom ended up travelling around the world and carrying the disease outside of China and throughout Asia. Other infected visitors of the hotel included a young Hong Kong resident who was visiting a friend. He fell ill, and after his admittance to the Prince of Wales Hospital (PWH) in Hong Kong, another SARS outbreak sparked, yet it was not the largest of them all. The largest spreading event in Hong Kong occurred in Amoy Gardens, where a patient from PWH brought the disease to a private housing estate. Approximately 300 residents were subsequently infected. In general, residential compounds and hospital situations were the most risky in terms of infection. Notably, 22% of all probable SARS cases occurred in hospital and health-care workers.
The theory is that SARS-CoV mutated from a strain of coronavirus normally infecting only animals into a strain that afflicted humans, and from its initial mutation, SARS has continued to evolve and change. Unlike the coronavirus, however, SARS’ mutations did not prove beneficial to its survival. Because there was no vaccine or known cure and humans did not have much ability to fight the virus, the SARS virus had little selective pressure to evolve to become stronger. Following Hong Kong’s restrictive quarantine and preventative measures, the city entered the year of 2004 free of the epidemic, though the ghost of the SARS epidemic continues to haunt the city to this day.
Thanks again for visiting my DYO website! I hope you enjoyed reading about the things I researched just as much as I enjoyed this month of work. I hope you walk away today having discovered something new :)
Sources:
Hung, Lee Shiu. "The SARS Epidemic in Hong Kong: What Lessons Have We Learned?" Journal of the Royal Society of Medicine, August 2003. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC539564/.
"Is the SARS Virus Mutating?" Nature, June 2003. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095144/.
Lau, Eric HY, C. Agnes Hsiung, Benjamin J. Cowling, Chang-Hsun Chen, Lai-Ming Ho, Thomas Tsang, Chiu-Wen Chang, Christl A. Donnelly, and Gabriel M. Leung. "A Comparitive Epidemiologic Analysis of SARS in Hong Kong, Beijing and Taiwan." BMC Infectious Diseases, March 2010.
Lau, J T F, X. Yang, H. Tsui, and J H Kim. "Monitoring Community Responses to the SARS Epidemic in Hong Kong: From Day 10 to Day 62." Evidence Based Public Health Policy and Practice.
Ma, Ngok. "SARS and the Limits of Hong Kong SAR Administrative State." Asian Perspective 28, no. 1 (2004). https://www.jstor.org/stable/42704445?seq=2#metadata_info_tab_contents.
Riley, Steven, Christopher Fraser, Christl A. Donnelly, Azra C. Ghani, Laith J. Abu-Raddad, Anthony J. Hedley, Gabriel M. Leung, Lai-Ming Ho, Tai-Hing Lam, Thuan Q. Thach, Patsy Chau, King-Pan Chan, Su-Vui Lo, Pak-Yin Leung, Thomas Tsang, William Ho, Koon-Hung Lee, Edith M. C. Lau, Neil M. Ferguson, and Roy M. Anderson. "Transmission Dynamics of the Etiological Agent of SARS in Hong Kong: Impact of Public Health Interventions." Science 300 (June 20, 2003).
Satija, Namita, and Sunil K. Lal. "The Molecular Biology of SARS Coronavirus." US National Library of Medicine.
"Severe Acute Respiratory Syndrome Epidemic in Asia." US Centers for Disease Control and Prevention.
Xu, Xiang, Yunqing Liu, Susan Weiss, Eddy Arnold, Stefan G. Sarafianos, and Jianping Ding. "Molecular Model of SARS Coronavirus Polymerase: Implications for Biochemical Functions and Drug Design." Nucleic Acids Research, December 15, 2003.
Yu, I.T.S., and J.J.Y. Sung. "The Epidemiology of the Outbreak of Severe Acute Respiratory Syndrome (SARS) in Hong Kong - What We Know and What We Don't." Epidemiology and Infection.