Figure 1: NOR islet with no insulitis, insulin (red), glucagon (green), and nuclei (blue)
Figure 2: Beginning stages of insulitis
Figure 3: No insulin production
Figure 1 is an image of an islet-stained pancreas in an NOR mouse. There is no insulitis, as would be expected from a mouse without diabetes. This image depicts typical production of insulin and glucagon.
Figure 4: ABPAS staining of large intestine. Goblet cells and mucus layer shown in dark purple.
Figure 5: Mucus (green) fluorescent image of mucus layer in the large intestine. Nuclei are stained blue.
Figure 6: FISH staining in large intestine. Nuclei are blue, firmicutes are red, bacteroidetes are green, and universal is yellow.