By Michael R. Gordon, Special To the New York Times / Dec. 29, 1990
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Britain announced today that it would join the United States in inoculating troops in the Persian Gulf against biological weapons.
The British Defense Ministry said it was ordering protective measures including the provision of respirators and special clothing and "a program of inoculation and provision of antibiotics and antitoxins."
The British announcement came as the Pentagon publicly confirmed that it planned to begin vaccinating American troops soon. Pentagon spokesmen today declined to say precisely what vaccines would be given or how many soldiers would be inoculated.
But Dr. Kenneth L. Wilcox, the deputy director of the Michigan Department of Public Health, said in an interview today that his agency had increased the production of a vaccine for anthrax, and was continuing to expand the production, in response to a request from the Army.
Called the Only Producer
Dr. Wilcox said the department was the only institution in the United States that made the vaccine.
Government officials familar with classified intelligence reports said Washington was concerned by Iraq's ability to use anthrax as a biological weapon.
Dr. George French of the Salk Institute for Biological Studies said his organization had received a request from the Army two weeks ago to manufacture a vaccine to counteract botulism. The vaccine is made at a laboratory in Swift Water, Pa.
Delbert Glanz, a vice president at the Salk Insitute, said it would "take some time" before a large quantity of that vaccine could be produced, since the program was just getting under way.
Details of the Pentagon's vaccination plan remain secret. A Pentagon spokesman said today that no officials were available to give interviews on the program and refused to discuss key aspects of the program.
Not Enough Vaccine
The program is politically sensitive because officials say the United States does not now have enouch vaccine to protect all servicemen and women in the Persian Gulf -- let alone to protect allied forces and Saudi citizens.
The Pentagon has not said when it might have enough vaccine for all American forces or fully explained how allies are to be protected. Nor has it explained how long it will take for the vaccinations to provide the American troops with full immunity against Iraqi biological weapons.
Dr. Wilcox said the anthrax vaccine was customarily given in two or three shots a couple of weeks apart.
"The immunity gradually increases as the time goes along," he said.
Some experts on chemical and biological weapons complained today that the Pentagon did not appear to be sufficiently prepared to deal with the problem of biological weapons.
Pentagon Is Criticized
Elisa D. Harris, a specialist at the Brookings Institution, questioned why the Pentagon did not yet have enough vaccine available to inoculate all the American troops and why it had not vaccinated the troops earlier.
"Given that we have been aware of Iraq's effort to develop biological weapons for a considerable period of time, the Pentagon should have had effective contingency plans for procuring adequate supplies of the vaccine before now and for carrying out a prompt vaccination program," Ms. Harris said.
Pentagon spokesmen declined to respond to this criticism, saying they could not go beyond the official statement today that a program of inoculations was to begin soon. But a Pentagon official, who spoke only on the condition that he not be identified, asserted that the criticism was misplaced.
"Very few places are equipped to make this stuff," the official said. "It is difficult to ramp up production, but we started that early on."
Flotilla Sets Sail
Although Pentagon officials said on Thursday that the vaccination program would begin in a matter of weeks, an official said today that the inoculations would begin much sooner, perhaps as soon as next week.
The confirmation of the vaccination program came as the a large Navy flotilla set sail for the gulf. Two aircraft carrier battle groups, a 17-ship armada carrying 16,000 sailors and marines, left from several ports.
The aircraft carriers America and Theodore Roosevelt and various support ships left from Norfolk Naval Base in Virginia. Other vessels in the battle group left from Mayport, Fla., and New York City.
The ships are to be in the gulf by mid-January, and the United States will then have six aircraft carriers in the region. It will be the first time since the Korean War that the Navy has deployed six carriers in a single military operation. Each carries about 80 planes, about 30 of which are designed to attack targets on land.
By Malcolm W. Browne / Jan. 6, 1991
1991-01-06-nytimes-confrontation-in-the-gulf-army-reported-ready-for-iraqi-germ-warfare.pdf
American military personnel in front-line positions in Saudi Arabia will be adequately protected against all but the heaviest doses of Iraqi biological warfare agents in the event of war, an Army expert says.
The officer, Col. Ronald G. Williams, commander of the Army's Medical Research Institute of Infectious Diseases at Fort Detrick, Md., said his command had been "forced to assume" that Iraq could attack American troops with a range of biological agents.
"We know that they have manufactured and used chemical weapons in Iran and Kurdistan, and that they therefore could produce and use biological agents as well," he said in a recent telephone interview from Fort Detrick.
Colonel Williams's command is responsible for developing protective techniques, vaccines and antitoxins for American troops against all disease-causing agents, including bacteria, viruses, funguses and toxins.
One of the main military concerns is anthrax, a potentially lethal disease that can infect most animals, including humans. The most dangerous form of the disease, pulmonary anthrax, can be spread through the air in the form of microscopic spores, and Iraq is believed to have sufficient supplies of anthrax to infect a large area. Anthrax can be spread by explosive shells, bombs or rockets. Three Types of Defense
Colonel Williams said protection against anthrax comprises three basic defenses: protective clothing and masks, which are also used against chemical agents, vaccination and antibiotic therapy.
The anthrax vaccine available to American forces, prepared from killed anthrax bacteria, is effective against the major known forms of the disease, Colonel Williams said. But he warned, "If a vaccinated person were exposed to an overwhelemingly large dose, the protection might not be effective."
The anthrax immunization procedure for American forces consists of an initial injection followed by two booster injections, one after two weeks and the second after four weeks. Troops receiving their initial injections now will not be fully immunized until their final booster injections nearly a month from now, by which time war may have begun. Production of anthrax vaccine has been increased, Colonel Williams said, but supplies will remain limited to "units at the greatest risk" for the time being.
Even if a soldier were to contract anthrax, military authorities believe that antibiotic therapy will be effective. But Colonel Williams and other experts fear that Iraqi bacteriologists may be capable of developing anthrax strains resistant to antibiotics, a possibility that would greatly increase the vulnerability of American troops.
Some of the biological-warfare diseases that Iraq might disseminate, including anthrax, are endemic in many parts of the world, including Saudi Arabia. The public health authorities have developed many strategies for fighting these diseases. The first anthrax vaccine was developed by Louis Pasteur more than a century ago.
But the genes of disease-causing organisms can be altered by nature or human beings. Genetic changes can produce diseases that defeat existing public health strategies, and when this happens, devastating epidemics can result. American experts hope that even during a crisis, Iraq will not be tempted to resort to germ warfare.
Iraq is believed to have developed a range of different biological agents, including organisms that cause cholera and typhoid, as well as potent biological toxins, including botulin toxin and rycin. Rycin, derived from castor beans, has been used by Bulgarian secret agents for assassinations. Some Vaccines Listed
Colonel Williams declined to comment on subjects that might compromise "intelligence or operational" secrets, including Washington's assessment of Iraq's biological arsenal. But he said his command had developed vaccines against tularemia, Rift Valley fever, Q fever, several forms of hemorrhagic fever and a variety of toxins.
Toxins are especially lethal when used to contaminate water supplies. Dr. Raymond A. Zilinskas of the Maryland Biotechnical Institute said in a 1989 report to the American Association for the Advancement of Science that one pound of toxin produced by the salmonella bacteria that cause typhoid could poison a 1.32-million gallon reservoir enough to kill anyone taking a drink. It would take 5 tons of nerve gas or 10 tons of potassium cyanide to achieve the same result, he said.
Iraq is believed to have manufactured large quantities of botulin toxin. Colonel Williams said that his research group had developed an experimental vaccine against botulin, and that the drug had been used on laboratory workers. It apparently protects them against accidental poisoning by the toxin, he said. As an experimental drug, however, the vaccine is not likely to be available in large amounts.
Nevertheless, the Pentagon plans to inoculate at least some of the servicemen and women serving in the Persian Gulf region with the botulin vaccine. On Dec. 21 the Defense Department obtained a special waiver enabling the military authorities to inoculate troops with the experimental drug, even without their informed consent.
https://www.newspapers.com/image/975899773/?match=1&terms=%22botulism%20vaccine%22
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0ther source - https://www.newspapers.com/image/791046473/?match=1&terms=%22botulism%20vaccine%22
MENTIONED - Dr. Barbara Hatch Rosenberg (born 1930)
https://www.newspapers.com/image/461923156/?match=1&terms=%22botulism%20vaccine%22
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zagury articl e...
https://www.latimes.com/archives/la-xpm-1987-03-19-mn-14079-story.html
1987-03-19-latimes-la-xpm-1987-03-19-mn-14079-story.pdf
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By ROBERT STEINBROOK
March 19, 1987 12 AM PT
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Times Medical Writer
A French AIDS scientist has injected himself with a prototype AIDS vaccine, thus beginning the first human testing of a vaccine against the deadly illness, it was reported today.
The researcher, Dr. Daniel Zagury, a professor of immunology at the Pierre and Marie Curie University in Paris, has developed evidence of an immune response to the test vaccine. But that result is to be expected whenever a person with normal immune function is exposed to foreign proteins.
This preliminary result does not prove that the test vaccine has any protective value against the AIDS virus because Zagury has never been exposed to the lethal virus.
His self-experimentation was potentially dangerous because there was no way to predict whether he would suffer side effects, such as immune system damage or even the development of AIDS.
But so far, Zagury said he has suffered no ill effects from the injection last November, according to a letter he and 11 colleagues wrote to Nature, a British scientific journal.
“I had to be sure it was safe in myself” before giving it to anyone else, Zagury, 59, said in a telephone interview. “I am a scientist, a physician and an immunologist. I worked on this for three years. I am not crazy.”
Since November, Zagury has received a second injection of the test vaccine and expanded his tests to include a number of other French researchers as well as a “small group” of volunteers from Zaire. But he cautioned that much more research is necessary to see if the preparation is “a good candi date vaccine.”
Zagury’s results were described as encouraging by leading American AIDS vaccine researchers, who nevertheless expressed astonishment that he was actually conducting the tests. For such human tests to be conducted in the United States, approval by the U.S. Food and Drug Administration and the research institutions involved would have been needed. Several research groups are in the process of applying for such authorization.
“It would have been premature for us to do this,” said Dr. Bernard Moss of the National Institutes of Health. Moss provided Zagury with viral materials last year for monkey experiments that were apparently used by the French scientist in developing his test vaccine.
Vaccines, designed to protect healthy people from acquiring a disease, usually contain weakened or dead germs. Once injected into the bloodstream, they work by inducing the body’s immune system to produce protective molecules called antibodies as well as special white blood cells that can eliminate foreign organisms. Thus, an AIDS vaccine would stimulate the body to protect itself against the AIDS virus.
Some researchers said they were surprised by Zagury’s use of a live-virus vaccine made with recombinant DNA technology--a technique that has triggered debate about its potential hazards. One fear is that such a vaccine might cause recipients with weakened immune systems to develop a serious viral infection similar to infections seen in AIDS patients.
Live-Virus Vaccine Method
In the recombinant live-virus approach, genes from the AIDS virus are inserted into the vaccinia, or cowpox, virus, which normally is used to immunize humans against smallpox.
The live-virus vaccine method has attracted widespread interest in AIDS research because it is thought to stimulate a strong immune response. It also may be effective against multiple strains of the AIDS virus--an important consideration because the AIDS virus has been identified in numerous variations.
But the potential drawbacks of recombinant vaccinia preparations were highlighted just last week. Researchers at the Walter Reed Army Medical Center in Washington described the case of a military recruit infected with the AIDS virus who had not yet become ill. After receiving a smallpox shot, he developed a vaccinia infection throughout his body and then developed AIDS. He died a few months later.
A Dedicated Scientist
Because of such considerations, it is uncertain whether Zagury’s experiments will accelerate the pace of AIDS vaccine research. It is expected to take at least five to 10 years to develop a safe and effective AIDS vaccine that can be used throughout the world.
Zagury, who has collaborated on other AIDS research with Dr. Robert C. Gallo of the National Cancer Institute, a co-discoverer of the AIDS virus, is described by colleagues as a dedicated scientist who became passionately committed to fighting AIDS after witnessing the devastation caused by the disease in Africa. “He is doing all this for humanitarian reasons,” Moss said.
Other researchers expressed similar views. “He’s got a lot of guts,” said Laurence A. Lasky of Genentech Inc., a South San Francisco-based genetic engineering firm.
“I wouldn’t do it myself; I’m a more conservative person,” said Scott Putney of Repligen Corp., a Cambridge, Mass., research company.
A Maverick Figure
Zagury first emerged as a maverick figure in AIDS research after it was disclosed last year that he was secretly testing a therapy to boost the immune system of about 20 patients in Zaire who were already infected with the AIDS virus.
These experiments, which were approved by the Zaire government, involve removing white blood cells from the patients and then infecting the cells with massive amounts of the AIDS virus. The infected cells are killed with chemicals and then injected back into the patient’s muscles.
Zagury, who has previously refused to discuss the tests, said these patients are “doing well,” but he declined to elaborate.
Zagury’s self-experimentation followed tests of his vaccine preparation in monkeys, baboons and a chimpanzee, which the scientist said demonstrated the approach was “absolutely innocuous and harmless.”
After receiving the injection himself, Zagury monitored his immune system for adverse effects and evidence of response to the vaccine over a nine-week period. The immune response was strongest against the strain of the AIDS virus used in developing the vaccine but there was some response to “a very different strain” as well, according to the letter published in today’s issue of Nature.
Ongoing Tests
Zagury’s ongoing human vaccine tests are comparable to what scientists call a “Phase 1” trial, in which a small number of people are injected with an experimental vaccine and then closely monitored through blood tests and exams for possible side effects.
The next phases would be larger trials to determine dosage and whether the vaccine actually works.
The AIDS virus, which attacks the body’s immune system, is transmitted through contaminated blood, sexual contact and from infected mother to child. As of March 16, 32,825 Americans had contracted AIDS and 19,021 had died.