◆主要な研究論文◆
(8) Jaw1 controls the granule abundance at a distinct ER compartment of pancreatic acinar cells.
Sato, H., Bandalan, M. F., Tantrakarn, K., Nakano, K., Okamura, T., Kawamura, Y. I., Dohi, T., Tonozuka, T., Nishikawa, A., *Kozono, T. Cell Struct. Funct. (2026). (in press)
https://doi.org/10.1247/csf.26040
(7) Jaw1 accelerates the reaction speed of the Ca2+ signals via ITPRs upon GPCR stimulation.
Kozono, T., Matsui, H., Bandalan, M. F., Tonozuka, T., *Nishikawa, A. Sci. Rep. 15 (1), 10104 (2025). https://doi.org/10.1038/s41598-025-94489-x
(6) Cleavage of the Jaw1 C-terminal region enhances its augmentative effect on the Ca2+ release via IP3 receptors.
Kozono, T., Jogano, C., Okumura, W., Sato, H., Matsui, H., Takagi, T., Okumura, N., Takao, T., Tonozuka, T., *Nishikawa, A. J. Cell Sci. 136 (4), jcs260439 (2023). (Selected as “Research Highlight” in the issue)
https://doi.org/10.1242/jcs.260439
(5) Jaw1/LRMP is associated with the maintenance of Golgi ribbon structure.
Okumura, W., Tadahira, K., Kozono, T., Tamura-Nakano, M., Sato, H., Matsui, H., Dohi, T., Rohrer, J., Tonozuka, T., *Nishikawa, A. J. Biochem. 173 (5), 383-392 (2023).
https://doi.org/10.1093/jb/mvad004
(4) Jaw1/LRMP increases Ca2+ influx upon GPCR stimulation with heterogeneous effect on the activity of each ITPR subtype.
Okumura, W., Kozono, T., Sato, H., Matsui, H., Takagi, T., Tonozuka, T., *Nishikawa, A. Sci. Rep. 12 (1), 9476 (2022).
https://doi.org/10.1038/s41598-022-13620-4
(3) Novel protocol to observe the intestinal tuft cell using transmission electron microscopy.
*Kozono, T., Tamura-Nakano, M., Kawamura, Y. I., Tonozuka, T., Nishikawa, A. Biol. Open 11 (2), bio059007 (2022).
https://doi.org/10.1242/bio.059007
(2) The N-terminal region of Jaw1 has a role to inhibit the formation of organized smooth endoplasmic reticulum as an intrinsically disordered region.
Kozono, T., Sato, H., Okumura, W. Jogano, C., Tamura-Nakano, M., Kawamura, Y. I., Rohrer, J., Tonozuka, T., *Nishikawa, A. Sci. Rep. 11 (1), 753 (2021).
https://doi.org/10.1038/s41598-020-80258-5
(1) Jaw1/LRMP has a role in maintaining nuclear shape via interaction with SUN proteins.
Kozono, T., Tadahira, K., Okumura, W., Itai, N., Tamura-Nakano, M., Dohi T., Tonozuka, T., *Nishikawa, A. J. Biochem. 164 (4), 303-311 (2018).
◆共著論文◆
(22) Enzymatic and Structural Characterization of a Branching Enzyme FdBE2 from the Gut Bacterium Faecalibacterium duncaniae.
Ding, Y., Sugimura, R., Kusama, M., Suzuki, R., Endo, A., Nishikawa, A., Kozono, T., *Tonozuka, T. J. Appl. Glycosci. (2026). (in press)
(21) Spatial, histochemical, and ultrastructural analysis of melanomacrophages in the liver of the red-eared slider (Trachemys scripta elegans).
Kasamatsu, K., Kozono, T., Lola, M. S. G., Yoshida, T., *Kigata, T. Anat. Histol. Embryol. 55 (6), e70178 (2026).
(20) Dietary stearic acid accelerates intestinal tumorigenesis via fatty acid-binding protein 5 without promoting obesity.
Nakata, K., Komiyama, S., Sekine, K., Nagai, M., Okawa, T., Ohashi, W., Nakano, K., Okamura, T., Kozono, T., Takemura, N., Yamada, K., Kokudo, N., Dohi, T., Hase, K., *Kawamura, Y. I. Cell. Mol. Gastroenterol. Hepatol. 20 (5), 101740 (2026).
(19) Tppp3 determines basal body positioning and identity of respiratory cilia via microtubule assembly and sphingolipid homeostasis.
Sakai, T., Kawakita, M., Seki, A., Takaoka, K., Kurata, M., Torikai, J., Atsumi, S., Yawata, K., Noi, K., Fukutani, Y., Noguchi, K., Kiyokawa, H., Morimoto, M., Takeuchi, E., Minegishi, K., Aoki, Y., Fujimura, S., Nishizaka, T., Inoue, T., Nagaoka, K., Tsugawa, H., Hayashi, H., Ishiguro, H., Kozono, T., Ohsawa, I., Fujita, Y., Matsunami, H., Hamada, H., Shinohara, K. Proc. Natl. Acad. Sci. U. S. A. 122 (49), e2503931122 (2025).
(18) Large-area TEM imaging for characterization of fibrillated cellulose across microscale to nanoscale.
Koizumi, H., Kitagawa, T., Okubo, K., Kozono, T., Kose, R. Cellulose 33 (1), 53-64 (2025).
(17) Characterization of a Fructan Exohydrolase from the Gut Bacterium Anaerostipes butyraticus.
Baula, M. A. B., Sekine, M., Kozono, T., Nishikawa, A., Kitano, Y., Endo, A., *Tonozuka, T. J. Appl. Glycosci. 72 (4), 7204102 (2025).
(16) Surveillance of Amyloid A Deposits in Commercial Beef Liver and Assessment of Food Hygiene Risks.
*Iwaide, S., Kobayashi, N., Owaku, K., Sedghi Masoud, N., Ujike, N., Itoh, Y., Kozono, T., Hisada, M., Kimura, K., Shibahara, T., Murakami, T. J. Vet. Med. Sci. 87 (8), 887-893 (2025).
(15) Crystal structure of CcGH131B, a protein belonging to glycoside hydrolase family 131 from the basidiomycete Coprinopsis cinerea.
Shiojima, Y., Sano, R., Kozono, T., Nishikawa, A., Kojima, Y., Yoshida, M., Sunagawa, N., Igarashi, K., *Tonozuka, T. J. Appl. Glycosci. 72 (2), 7202104 (2025).
(14) Flutamide promotes early hepatocarcinogenesis through mitophagy in high-fat diet-fed non-obese steatotic rats.
Hara, E., Ohshima, K., Takimoto, M., Bai, Y., Hirata, M., Zeng, W., Uomoto, S., Todoroki, M., Kobayashi, M., Kozono, T., Kigata, T., Shibutani, M., *Yoshida, T. Int. J. Mol. Sci. 26 (6), 2709 (2025).
(13) Infection pattern of male-killing viruses alters phenotypes in the tea tortrix moth Homona magnanima.
*Takamatsu, T., Arai, H., Itoh, Y., Kozono, T., Wu, C. F., Kitaura, K., Moriyama, H., *Inoue, M. N. Heredity 134 (2), 120-128 (2025).
(12) Macro- and microscopic anatomy of the digestive tract in the red-eared slider (Emydidae: Trachemys scripta elegans).
Miyai, N., Kozono, T., Kuriki, T., Todoroki, M., Murakami, T., Shinohara, K., Yoshida, T., *Kigata, T. PLOS ONE 19 (12), e0315737 (2024).
(11) Peroxisome Proliferator Activator α Agonist Clofibrate Induces Pexophagy in Coconut Oil-Based High-Fat Diet-Fed Rats.
Ohshima, K., Hara, E., Takimoto, M., Bai, Y., Hirata, M., Zeng, W., Uomoto, S., Todoroki, M., Kobayashi, M., Kozono, T., Kigata, T., Shibutani, M., *Yoshida, T. Biology 13 (12), 1027 (2024).
(10) Anorectal Remodeling in the Transitional Zone with Increased Expression of LGR5, SOX9, SOX2, and Keratin 13 and 5 in a Dextran Sodium Sulfate-Induced Mouse Model of Ulcerative Colitis.
Kobayashi, M., Usui, T., Elbadawy, M., Kigata, T., Kaneda, M., Murakami, T., Kozono, T., Itoh, Y., Shibutani, M., *Yoshida, T. Int. J. Mol. Sci. 25 (23), 12706 (2024).
(9) Alcoholysis-induced changes in cell wall surfaces: Structural insights for the effective delignification of lignocellulosic biomass.
Kurei, T., Miyabayashi, M., Kozono, T., *Horikawa, Y. Int. J. Biol. Macromol. 280, 135496 (2024).
(8) Crystal structure of exfoliative toxin D from Staphylococcus aureus.
Sato, S., Ragab, R. F., Guo, X., Elfadadny, A., Kozono, T., Nishikawa, A., *Nishifuji, K., *Tonozuka, T. Biochem. Biophys. Res. Commun. 733, 150689 (2024).
(7) Systemic AL Kappa Chain Amyloidosis in a Captive Bornean Orangutan (Pongo pygmaeus).
Iwaide, S., Takemae, H., Oba, M., Owaku, K., Kobayashi, N., Itoh, Y., Kozono, T., Hisada, M., Miyabe-Nishiwaki, T., Watanuki, K., Yanai, T., Inoue, H., *Murakami, T. Res. Vet. Sci. 175, 105315 (2024).
(6) Structural basis for the recognition of α-1,6-branched α-glucan by GH13_47 α-amylase from Rhodothermus marinus.
Miyasaka, Y., Yokoyama, K., Kozono, T., Kitano, Y., Miyazaki, T., Sakaguchi, M., Nishikawa, A., *Tonozuka, T. Proteins 92 (8), 984-997 (2024).
(5) Characterization and alteration of product specificity of Beijerinckia indica subsp. indica β-fructosyltransferase.
Li, D., Miyasaka, Y., Kubota, A., Kozono, T., Kitano, Y., Sasaki, N., Fujii, T., Tochio, T., Kadota, Y., Nishikawa, A., *Tonozuka, T. Biosci. Biotechnol. Biochem. 87 (9), 981-990 (2023).
(4) Recombinant lectin Gg for Brain Imaging of Glycan Structure and Formation in the CNS node of Ranvier.
Tulin, E. K. C., Yoshimura, T., Nakazawa, C., Saito, S., Kanai, K., Kozono, T., Nakakita, S. I., Tonozuka, T., Ikenaka, K., *Nishikawa, A. J. Neurochem. 163 (6), 461-477 (2022).
(3) Structural basis for proteolytic processing of Aspergillus sojae α-glucosidase L with strong transglucosylation activity.
Ding, Y., Oyagi, A., Miyasaka, Y., Kozono, T., Sasaki, N., Kojima, Y., Yoshida, M., Matsumoto, Y., Yasutake, N., Nishikawa, A., *Tonozuka, T. J. Struct. Biol. 214 (3), 107874 (2022).
(2) Enzymatic and structural characterization of β-fructofuranosidase from the honeybee gut bacterium Frischella perrara.
Kubota, A., Kawai, R., Li, D., Kozono, T., Sasaki, N., Nishikawa, A., Fujii, T., Tochio, T., *Tonozuka, T. Appl. Microbiol. Biotechnol. 106 (7), 2455-2470 (2022).
(1) Study on Agricultural Management for Sustainable Agriculture in Zhangye Oasis, Middle Reaches of Heihe River Basin: A case study in Linze County.
*Zhou, M., Ozaki, A., Kobayashi, K., Kozono, T., Kanasugi, M. International Review for Spatial Planning and Sustainable Development 5 (4), 19-31 (2017).