微生物與生化實驗室
最新研究發表
《Monascinol from Monascus pilosus-fermented rice exhibits hypolipidemic effects by regulating cholesterol and lipid metabolism》
發表在《Journal of Functional Foods》期刊上,探討了一種名為 Monascinol (Msol) 的新型黃色色素在紅麴米中發酵產生,並研究其對膽固醇及脂質代謝的調控作用。Monascinol 是由 Monascus pilosus SWM-008 發酵紅麴米中產生的一種新型黃色色素,其結構類似於常見的紅麴米黃色色素 Monascin (MS)。此研究的目的在於探討 Msol 在高脂高膽固醇飲食誘導的高脂血症倉鼠模型中的降脂效果及其機制,並與 MS 進行比較。
主要發現
降低肝臟炎症:Msol 能夠減少高脂血症倉鼠肝臟中的炎症反應。
抑制脂肪合成酶 (FASN) 和固醇調節元件結合蛋白 2 (SREBP2) 的表現:Msol 減少了這些基因在肝臟中的表現,這些基因與脂肪合成和膽固醇代謝密切相關。
增加糞便中甘油三酯 (TG) 和膽汁酸的排泄:這表明 Msol 促進了脂質的排出。
超越 MS 的 AMPK 磷酸化效果:Msol 在激活 AMP 活化蛋白激酶 (AMPK) 的磷酸化方面優於 MS,AMPK 是一種重要的能量調節酶。
結論
研究結果顯示,Msol 通過調節脂肪和膽固醇代謝,顯示出優異的降脂效果。此外,Msol 在降低甘油三酯水平和減輕炎症方面的效果也優於 MS。因此,Msol 作為紅麴米中的一種功能性成分,具有潛在的降脂效果,值得進一步研究和應用。
東部生物經濟中心食品生技工廠
東部生物經濟中心食品生技工廠
111 大學部專題畢業生
食品生技工廠
學經歷
學歷:國立臺灣大學微生物與生化學研究所 博士
學歷:國立臺灣大學微生物與生化學研究所 博士
現任:
國立臺東大學生命科學系教授
現任:國立臺東大學東部生物經濟中心主任
經歷:
國立臺東大學東部生物經濟中心 (校級研究中心) 中心主任 109/02 至今
臺灣深層海水資源利用學會 理事 103 / 8 至今
科技部專題研究計畫複審委員會 審查委員 108 至 109
國立臺東大學生命科學系 系主任 102/12 至109/01
國立臺東大學深層海水科技研發中心 主任 103 / 8至104/7
臺東縣深層海水利用發展協會監事 100/1 至 102/12
國立臺東大學生命科學系 教授 105.2 至今
國立臺東大學生命科學系 副教授 101.2至105.1
國立臺東大學生命科學系 助理教授 97.8至101.1
學術研究專長
專長:
微生物保健食品、健康食品功效評估 (血脂、肥胖、阿茲海默症、肝損傷、血糖、抗疲勞)、深層海水生技產品開發、發酵生物技術、動物試驗、動物細胞培養、蛋白質體學
專業證照:高考營養師
微生物與生化學研究室之研究方向
1. 機能性發酵製品之開發:紅麴菌、樟芝、蛹蟲草、蟲草蟬花、乳酸菌
2. 預防醫學之保健產品開發:阿茲海默症、高血脂、肥胖、糖尿病、酒精肝損傷、非酒精性脂肪肝、肝纖維化、抗疲勞
3. 深層海水應用生技領域:深層海水紅麴、深層海水樟芝、深層海水蟲草之發酵生產、離子吸收、保健功效
4. 蛋白質體學於生物科技與生物醫學之應用:微生物之蛋白質體學研究、動物細胞與組織之蛋白質體學研究
各項領域之研究相進行串聯,以發酵技術或天然素材結合深層海水開發得到機能性材料,並進一步應用於預防醫學之保健產品開發,得知保健素材之功效性後將進ㄧ步探討其作用機制,而此部份可藉由蛋白質體學來進行研究,以了解試驗物質對細胞層次及動物組織中蛋白質表現之影響,藉此探討其作用機制。
學術獎勵與榮譽
111年度 國立臺東大學傑出教學獎
112 年度保健食品學會營養保健食品創新獎 (紅藜牛樟芝菌絲體膠囊)
109年度 國立屏東科技大學青年傑出校友
108 年度指導科技大專生研究計畫研究創作獎
107-111 年度國科會補助大專校院研究獎勵
99-106 年度科技部獎勵特殊優秀人才
104 蔣徐蓮貞女士食品科技學會學術榮譽獎
執行計畫
研究計畫
1. 產學合作計畫:原民作物有機翼豆創新研發計畫。上上農漁品有限公司。經費:474,000元 (2022/08/01~2023/3/31)
2. 產學合作計畫:諾麗果複方草本天然發酵保健伴手禮開發。活泉自然生態農場。經費:300,000元 (2022/08/01~2023/6/30)
3. 產學合作計畫:翼豆蔬果飲與發酵飲之保健食品開發。晨辰有限公司。經費:395,000元 (2022/08/01~2023/6/30)
4. 產學合作計畫:在地特色水果麻糬開發。陳家麻糬商行。經費:258,000元 (2022/08/01~2023/6/30)
5. 產學合作計畫:鳳梨釋迦粉末化與優釋健康保健伴手禮開發。聚醫思健康研發有限公司。經費:400,000元 (2022/08/01~2023/6/30)
6. 國科會專題計畫:無橘黴素之功能紅麴菌株育種與放大生產以開發改善代謝症候群及腸道菌群之保健素材。經費:3,750,,000元 (2022/0801~2025/07/31)
7. 國家海洋研究院計畫:海洋產業發展與資源開發-深層海水食品微生物之資料庫建立與其發酵生長代謝分析之研究。經費:1,600,,000元 (2022/06/01~2022/11/21)
8. 產學合作計畫:紅麴菌改善非酒精脂肪肝與腸道菌群功效研究。晨暉生物科技股份有限公司。經費:1,360,000元 (2022/08/01~2023/12/31)
9. 農委會科技計畫:台東鳳梨釋迦之多元加工開發與高值化產品於食品生技工廠之試生產。經費:800,000 (2022/01/01~2022/12/31)
10. 產學合作計畫:紅麴菌調節血糖與腸道菌群功效研究。經費:1,800,000元 (2022/03/31~2023/02/28)
11. 產學合作計畫:咖啡豆之循環經濟與深層海水機能胜肽咖啡產品開發,共生農業有限公司。經費:270,000元 (2021/08/15~2022/7/31)
12. 產學合作計畫:以台東木虌果與洛神花研發天然胡蘿蔔素與花青素A++保健產品,東台灣農特產行。經費:322,000 元(2021/08/15~2022/7/31)
13. 產學合作計畫:新型益生菌果乾與洛神花果飲之研發,團體兔廣告有限公司。經費:252,000 元(2021/08/15~2022/7/31)
14. 產學合作計畫:黑蜆之深層海水養殖及水解胜肽萃蜆精保健產品開發,曜妍有限公司,經費:276,000 元 (2021/08/15~2022/7/31)
15. 產學合作計畫:深層海水紅烏龍益生菌錠與口服粉包之研發,海邇思健康研發有限公司,經費:500,000 元 (2021/08/15~2022/7/31)
16. 科技部專題計畫:以富含有機離子與高三萜類產量之深層海水牛樟芝固態發酵物進行預防阿茲海默症保健食品開發與試量產。經費 900,000元 (2020/08/01~2021/07/31)。
17. 晨暉生物科技股份有限公司: 紅麴菌調節血脂功效研究。經費:1,200,000元 (2021/04/10~2022/4/9)。
18. 行政院農業委員會水土保持局:「110年大專院校農村實踐共創計畫」鹿野紅烏龍茶之保健新產品開發。經費:300,000 元 (2021/01/01~2021/12/31)。
19. 農業科技產學計畫:乳酸菌發酵紅藜之抗疲勞高蛋白保健飲開發與試量產。經費:1,150,000元。合作企業:時健力股份有限公司 (2021/01/01~2021/12/31)
20. 科技部循環材料高值化專案旗艦計畫 (產學合作計畫):以深層海水結合微生物發酵技術開發高功能性深層海水保健產品IV (MOST 109-2218-E-143-001)。經費:2,170,000元。合作企業:美國 Biomedical Ltd. (2020/06/01~2021/5/31)
21. 美國 Acro Biomedical Ltd. 之配合科技部計畫委託研究:以深層海水結合微生物發酵技術開發高功能性深層海水保健產品之配合研究IV;配合款: 550,000元 (2020/06/01~2021/5/31)
22. 科技部專題計畫:以ARTP 誘變育種高三萜類產量與高深層海水離子吸收率之牛樟芝菌以開發預防阿茲海默症保健食品 (MOST 109-2320-B-143-002)。經費 968,000元 (2020/08/01~2021/07/31)
23. 台美檢驗科技有限公司委託評估計畫:螺旋藻錠健康食品調節血脂評估。經費:650,000元。(2020/08/01~2021/12/31)
24. 粨種人食品股份有限公司委託研究:功能性假酸漿葉萃取技術開發及其萃取錠與即食粉之保健產品開發。經費 483,000元 (2020/07/01~2021/06/30)
25. 禾沂國際有限公司委託研究:初乳益生菌錠與即食粉包之保健產品開發。經費 310,000元 (2020/07/01~2021/06/30)
26. 原穀傳說有限公司委託研究:水解蛋白技術於樹豆紅藜能量飲與樹豆能量咖啡產品研發與試量產。經費 308,000元 (2020/07/01~2021/06/30)
27. 竹田竹木行委託研究:以深層海水培養牛樟芝子實體之滴粒保健產品開發與試量產。經費 245,000元 (2020/08/01~2021/05/31)
28. 聚醫思健康研發有限公司委託研究:鹿角靈芝紅藜滴丸及濃縮飲製程及動物試驗研究計畫。經費 300,000元 (2019/08/01~2020/07/31)
29. 七里坡有限公司委託研究:木虌果胡蘿蔔素營養飲研發計畫。經費 265,000元 (2019/08/01~2020/07/31)
30. 東台灣有限公司委託研究:紅薑黃洛神花萃取濃縮技術與即食即冲保健飲研發計畫。經費 354,000元 (2019/08/01~2020/07/31)
31. 經濟部工業局即時技術輔導計畫:香檬果汁粉末化製程輔導與粉末產品之分級應用。經費 200,000元 (2019/06/01~2019/10/31)
32. 科技部循環材料高值化專案旗艦計畫 (產學合作計畫):以深層海水結合微生物發酵技術開發高功能性深層海水保健產品(3/3)。經費:1,700,000元。合作企業:慕求生物科技股份有限公司,
33. 慕求生物科技股份有限公司之配合科技部計畫委託研究:以深層海水結合微生物發酵技術開發高功能性深層海水保健產品之配合研究;配合款: 550,000元 (2019/06/01~2020/5/31)
34. 台美檢驗科技有限公司委託評估計畫:牛樟芝菌絲體產品改善非酒精脂肪肝之功效評估。經費:900,000元。(2019/01/01~2019/12/31)
35. 大江生醫股份有限公司委託研究:功能性植物原料開發。經費:300,000元。(2018/09/01~2019/8/31)
36. 深層海水學會委託研究:深層海水複方原料開發及其功效驗證研究。經費:500,000元。(2018/03/01~2018/9/30)
37. 科技部循環材料高值化專案旗艦計畫 (產學合作計畫):以深層海水結合微生物發酵技術開發高功能性深層海水保健產品(2/3)。經費:1,700,000元。合作企業:慕求生物科技股份有限公司,配合款: 500,000元 (2018/06/01~2019/5/31)
38. 慕求生物科技股份有限公司之配合科技部計畫委託研究:以深層海水結合微生物發酵技術開發高功能性深層海水保健產品之配合研究I;配合款: 500,000元 (2018/06/01~2019/5/31)
39. 台美檢驗科技有限公司委託評估計畫:紅麴調節血糖功效評估。經費:850,000元。(2018/08/01~2019/12/31)
40. 科技部循環材料高值化專案旗艦計畫 (產學合作計畫):以深層海水結合微生物發酵技術開發高功能性深層海水保健產品(1/3)。經費:1,300,000元。(2017/06/01~2018/5/31)
41. 台灣檢驗科技股份有限公司委託評估計畫:馬玉山高纖大燕麥片健康食品調節血脂功效評估試驗。計畫經費:1,000,000 元 (2017/09/01~2018/12/31)
42. 科技部三年期計畫:以臺東深層海水發酵之真菌開發預防失智症之保健食品。經費:3,995,000元。(2016/08/01~2019/7/31)
43. SBIR地方型計畫 (美麗優國際有限公司):釋迦奶凍飲與釋迦奶酪創新產品開發計畫。經費:450,000元。(2017/09/01~2018/8/31)
44. SBIR地方型計畫:台東檸檬風味的紅龍果口嚼錠與保濕抗氧化產品創新開發計畫。經費:350,000元。(2017/09/01~2018/8/31)
45. 晨暉生物科技股份有限公司委託評估計畫:紅麴成分 dimerumic acid、deferricoprogen、monascin 與 ankaflavin預防酒精性肝損傷功效評估。經費:1,300,000元。 (2016/04/01~2017/12/31)
46. 台美檢驗科技有限公司委託評估計畫:深層海水飲料之健康食品抗疲勞功效評估。經費:600,000元 (2016/02/01~2017/2/28)。
47. 福智祿股份有限公司委託評估計畫:福智祿牛樟芝菌絲體膠囊之健康食品調節血糖功效評估。經費:800,000元。(2017/02/01~2017/10/31)
48. 經濟部工業局105年度保健食品產業創新加值輔導與推廣計畫:保健食品業者創新加值化技術輔導 — Monascus purpureus NTU 568 紅麴萃取物產品軟膠囊劑型開發與研究。經費:900,000元。合作企業:晨暉生物科技股份有限公司。(2016/03/01~2016/12/31)
49. 石資中心委託計畫:深層海水複方產品之功效評估。經費:200,000元。(2016/06/01~2016/12/31)
50. 經濟部一般型學界科專計畫:臺東深層海水產業關鍵技術之研發三年計畫 (第三年計畫) (104-EC-17-A-32-S1-230) 經費:1,564,189元 (2015/08/01~2016/08/31),子計畫主持人。
51. 台灣檢驗科技股份有限公司委託評估計畫:綠茶產品之健康食品調節血脂功效之正式試驗評估。計畫經費:650,000 元 104.11.20 ~105.06.30
52. SBIR 地方型計畫:開發高機能養生饅頭產品,委託經費:200,000元,2015/9/01~2016/8/31。
53. 科技部產學計畫:開發具預防改善類澱粉樣蛋白誘發腦部損傷與記憶學習能力障礙效果之益生菌發酵豆奶萃取物與功效成分之發酵製程(II) (103-2622-E-143-001-CC2),合作企業:晨暉生物科技股份有限公司。經費:1,531,000 元,2014/11/01~2015/10/31,計畫主持人。
54. 信豐農業技術股份有限公司產學合作計畫:紅藜預防酒精性肝損傷保健食品開發之研究計畫。計畫經費:1,700,000元,2015/1/1~2016/12/31,計畫主持人。
55. 台灣檢驗科技股份有限公司委託評估計畫:蝦紅素膠囊產品之健康食品調節血脂功效之預試驗與正式試驗評估。計畫經費:1,000,000 元,2015/04/20~2016/06/30,計畫主持人。
56. 台灣檢驗科技股份有限公司委託評估計畫:茶飲料產品之健康食品調節血脂功效之預試驗評估計畫經費:110,000 元,2015/04/20~2015/09/30,計畫主持人。
57. 經濟部技術處東部微型產業輔導計畫:開發抗菌功能之苦楝油手工皂產品,經費:150,000元,104.6.1-104.10.31,計畫主持人。
58. 科技部產學計畫:開發具改善對 Aβ 誘發腦部損傷與記憶學習能力障礙之預防效果功能之益生菌發酵豆奶與功效成分之發酵製程 (102-2622-E-143-001-CC2),合作企業:晨暉生物科技股份有限公司。經費:1,368,000元,2013/11/01~2014/10/31,計畫主持人。
59. 經濟部一般型學界科專計畫:臺東深層海水產業關鍵技術之研發三年計畫 (第一年計畫) (102-EC-17-A-32-S1-230) 經費:1,129,930元 (2013/06/01~2014/05/31),計畫主持人。
60. 經濟部一般型學界科專計畫:臺東深層海水產業關鍵技術之研發三年計畫 (第二年計畫) (103-EC-17-A-32-S1-230) 經費:1,129,930元 (2013/06/01~2014/05/31) ,計畫主持人。
61. 科技部三年期專題計畫:探討臺東地區深層海水對功能性真菌之發酵生產與預防肝硬化保健功效提升之影響 (NSC101-2313-B-143-003-MY3) 經費:3,750,000元(2012/08/01~2015/07/31) 生物處食品農化學門,計畫主持人。
62. 國科會三年期專題計畫:深層海水對機能性微生物發酵生產與保健功效之研究開發98-2313-B-143-002-MY3 經費:3,679,000元 (2009/8/1~2012/7/31)生物處食品農化學門,計畫主持人。
63. 工業技術研究院計畫:應用深層海水於硒酵母之發酵生產研究,經費:500,000元(2012.5.1-2012.12.31),計畫主持人。
64. 工業技術研究院計畫:微生物生長速率曲線分析之研究,經費:300,000元(2011.2.1-2012.1.31),計畫主持人。
65. 工業技術研究院計畫:深層海水機能性生物評估,經費:300,000元(2011.10.1-2012.9.30),計畫主持人。
66. 國科會產學計畫:開發紅麴次級代謝物 monascin 與 ankaflavin 為改善阿茲海默症之功效成分99-2622-B-143-001-CC3經費:977,200 (2010/6/1~2011/5/31) 生物處食品農化學門,計畫主持人。
67. 國科會二年期專題計畫:樟芝發酵產物改善阿茲海默症記憶學習能力之功效開發與機制探討97-2321-B-143-001-MY2 1,800,000 (2008/12/1~2010/7/31) 生物處食品農化學門,計畫主持人。
大專學生專題計畫
1. 以反應曲面法探討具抑制阿茲海默症 amyloid beta-protein 神經細胞毒性之樟芝菌絲體發酵生產條件。經費:45,000元 (2009/07/01~2010/2/28) 生物處食品農化學門。
2. 以反應曲面法探討納豆菌二維電泳流程中破菌及蛋白質沉澱法之最適條件。經費:45,000元 (2010/07/01~2010/2/28) 生物處食品農化學門。
3. 深層海水中主要離子對紅麴菌代謝產物生成及蛋白質表現之影響NSC100-2815-C-143-011-B。經費:45,000元 (2011/07/01~2012/2/28) 生物處食品農化學門。
4. 以體外及體內試驗比較紅麴中 monascin、ankaflavin 與 monacolin K 對膽固醇生成與吸收之影響 NSC100-2815-C-143-010-B 。經費:45,000 元 (2011/07/01~2012/2/28) 生物處食品農化學門。
SCI 期刊論文
Liu CF, Young ZY, Shih TW, Pan TM*, Lee CL* . 2024. Lactobacillus-Deglycosylated Isoflavones Prevent Aβ 40-induced Alzheimer's disease in a Rat Model . AMB Express . (accept) (SCI)
Kim SJ, Na GH, Yim DJ, Liu CF, Lin TH, Shih TW, Pan TM, Lee CL* 2024. Lactobacillus paracasei subsp. paracasei NTU 101 prevents obesity by regulating AMPK pathways and gut microbiota in Obese Rat. Biochemical and Biophysical Research Communications (accept) (SCI)
Yang PX, Hsu YW, Pan TM, Lee CL*. 2024. Monascinol from Monascus pilosus-Fermented Rice Exhibits Hypolipidemic Effects by Regulating Cholesterol and Lipid Metabolism. J Func Food, (accept)
Liu CF, Pan TM, Lee CL*. 2024. The Mass-Produced Compound Extract from Antlered form of Ganoderma Lucidum and Red Quinoa Effectively Protects the Liver by Antioxidant and Anti-Inflammatory Mechanisms in Carbon Tetrachloride Induced Liver Fibrosis Animal Model. J Biotech Biores. 5(3). JBB. 000613. DOI: 10.31031/JBB.2024.05.000613
Liu CF, Zhang XF, Yu TL, Lee CL*. 2024. Utilizing Deep Ocean Water in Yeast Fermentation for Enhanced Mineral-Rich Biomass Production and Fermentative Regulation by Proteomics Modulation. Heliyon. 10(10) 30, e31031
Liu CF, Shih TW, Lee CL* Pan TM*. 2024. The Beneficial Role of Lactobacillus paracasei subsp. paracasei NTU 101 in the Prevention of Atopic Dermatitis. Curr. Issues Mol. Biol., 46(3), 2236-2250; https://doi.org/10.3390/cimb46030143
Xu TY, Tzeng DY, Lee CL*. 2023. Using Deep Ocean Water in the Fermentation of Antrodia cinnamomea to Boost Magnesium Ion Bioabsorption and Anti-Inflammatory Effects in the Brain of an Alzheimer’s Disease Rat Model. Fermentation, 9(10), 893; https://doi.org/10.3390/fermentation9100893
Chang CY, Yang PX, Yu TL, Lee CL*. 2023. Cordyceps cicadae NTTU 868 Mycelia fermented with deep ocean water minerals prevents d-galactose-induced memory deficits by inhibiting oxidative inflammatory factors and aging-related risk factors. Nutrients, 15(8), 1968; https://doi.org/10.3390/nu15081968 (SCI, IF:6.706).
Lin CW, Lin CH, Y, Hsu YW, Pan TM*, Lee CL*. 2023. Monascin and ankaflavin prevents metabolic disorder by blood glucose regulatory, hypolipidemic, and anti-inflammatory effects in high fructose and high fat diet-induced hyperglycemic rat. Journal of Functional Foods, 104, 105537 (2023.04) (SCI, IF 5.223)
Lin CW, Lin PY, Y, Hsu YW, Pan TM*, Lee CL*. 2023. Monascus-fermented metabolites repressed amyloid β-peptide-induced neurotoxicity and inflammatory response in in vitro and in vivo studies. Journal of Functional Foods, 104, 105509. (2023.03) DOI: 10.1016/j.jff.2023.105509 (SCI, IF 5.223)
Lin CH, Huang HL, Chen YH, Lee CL*. 2022. Deep Ocean Water Minerals Promotes the Growth and Cordycepin Production of Cordyceps militaris Fruiting Bodies through Proteomics Regulation. Fermentation. 2022, 8, 481. https://doi.org/10.3390/fermentation8100481
Lin TA, Ke BJ, Cheng CS, Lee CL*. 2021. Red Quinoa Bran Extract Prevented Alcoholic Fatty Liver Disease via Increasing Antioxidative System and Repressing Fatty Acid Synthesis Factors in mice fed Alcohol Liquid Diet. Molecules. 18;26(22):6973. doi: 10.3390/molecules26226973. (SCI, IF:4.412)
Lai JR, Hsu YW, Pan TM*, Lee CL*. 2021. Monascin and ankaflavin of Monascus purpureus prevent alcoholic liver disease through regulating AMPK-mediated lipid metabolism and enhancing anti-inflammatory and anti-oxidative systems. Molecules. 26(20), 6301; https://doi.org/10.3390/molecules26206301 (SCI, IF:4.412)
Lee CY, Lee CL*. 2021. Comparison of the improvement effect of deep ocean water with different mineral composition on the high fat diet-induced blood lipid and nonalcoholic fatty liver disease in a mouse model. Nutrients, 13(5), 1732; doi.org/10.3390/nu13051732 (SCI, IF:5.719)
Wu YZ, Lee CL*. 2021. Cordyceps cicadae NTTU 868 Mycelium with The Addition of Bioavailable Forms of Magnesium from Deep Ocean Water Prevents the Aβ40 and Streptozotocin-induced Memory Deficit via Suppressing Alzheimer’s Disease Risk Factors and Increasing Magnesium Uptake of Brain. Fermentation 7(1), 39 (SCI, IF:3.975).
Ke BJ, Lee CL*. 2019. Using submerged fermentation to fast increase N6-(2-hydroxyethyl)-adenosine, adenosine and polysaccharide productions of Cordyceps cicadae NTTU 868. AMB express 9:198 (SCI, IF 3.298).
Lai JR, Ke BJ, Hsu YW, Lee CL*. 2019. Dimerumic acid and deferricoprogen produced by Monascus purpureus attenuate liquid ethanol diet -induced alcoholic hepatitis via suppressing NF-κB inflammation signalling pathways and stimulation of AMPK-mediated lipid metabolism. J Func Food. 60, 103393 (SCI, IF:4.451).
Lin TA, Ke BJ, Cheng CS, Wang JJ, Wei BL, Lee CL*. 2019. Red quinoa bran extracts protects against carbon tetrachloride-induced liver injury and fibrosis in mice via activation of antioxidative enzyme systems and blocking TGF-β1 pathway. Nutrients. 11:395 (SCI, IF:5.719).
Lee CL, Wen JY, Hsu YW, Pan TM. 2018. The blood lipid regulation of Monascus-produced monascin and ankaflavin via the suppression of low-density lipoprotein cholesterol assembly and stimulation of apolipoprotein A1 expression in the liver. J Microbiol Immunol Infect. Feb;51(1):27-37. doi: 10.1016/j.jmii.2016.06.003. Epub 2016 Jun 24. (SCI, IF:4.399)
Ke BJ, Lee CL*. 2018. Cordyceps cicadae NTTU 868 mycelium prevents CCl4-induced hepatic fibrosis in BALB/c mice via inhibiting the expression of pro-inflammatory and pro-fibrotic cytokines. J Func Food 43: 214-223 (SCI, IF:4.451)
Lee CL, Pan TM*. 2017. The prevention of Alzheimer's disease and Parkinson’s disease by Monascus purpureus NTU 568-fermented compounds. J Alzheimers Dis Parkinsonism. 7:4 DOI: 10.4172/2161-0460.1000342
Hung YP, Lee CL*. 2017. Higher Anti-Liver Fibrosis Effect of Cordyceps militaris-Fermented Product Cultured with Deep Ocean Water via Inhibiting Proinflammatory Factors and Fibrosis-Related Factors Expressions. Mar Drugs. 8:15. pii: E168. doi: 10.3390/md15060168. (SCI, IF:5.118)
Wang JJ, Wu CC, Lee CL, Hsieh SL, Chen JB, Lee CI*. 2017. Antimelanogenic, Antioxidant and Antiproliferative Effects of Antrodia camphorata Fruiting Bodies on B16-F0 Melanoma Cells. PLoS One. 12(1) :e0170924. doi: 10.1371/journal.pone.0170924.
Lung TY, Liao LY, Wang JJ, Wei BL, Huang PY, Lee CL*. 2016. Metals of deep ocean water increase the anti-adipogenesis effect of Monascus-fermented product via modulating the monascin and ankaflavin production. Mar Drugs. 14(6). pii: E106. doi: 10.3390/md14060106. (SCI, IF:5.118)
Shia YC, Yang SY, Lee DY, Lee CL*. 2016. Increasing Anti-Aβ-induced neurotoxicity ability of Antrodia camphorata-fermented product with deep ocean water supplementary. J Sci Food Agri. 96: 4690–4701 DOI: 10.1002/jsfa.7687 (online) (SCI)
Lee CL*. 2015. The advantages of deep ocean water for the development of functional fermentation food. Appl Microbiol Biotechnol. 99: 2523-2531. DOI: 10.1007/s00253-015-6430-7 (SCI, IF 4.813)
Lee CL, Lin PY, Hsu YW, Pan TM. 2015. Monascus-fermented monascin and ankaflavin improve the memory and learning ability in amyloid β-protein intracerebroventricular-infused rat via the suppression of Alzheimer’s disease risk factors. J Func Food 18:387-399 (SCI, IF:4.451)
Hung YP, Wang JJ, Wei BL, Lee CL*. 2015. Effect of the salts of deep ocean water on the production of cordycepin and adenosine of Cordyceps militaris-fermented product. AMB express. 5:53. DOI 10.1186/s13568-015-0140-5 (SCI, IF 3.298)
Lee CI, Wu CC, Hsieh SL, Lee CL, Chang YP, Chang CC, Wang YZ, Wang JJ. 2014. Anticancer effects on human pancreatic cancer cells of triterpenoids, polysaccharides and 1,3-β-d-glucan derived from the fruiting body of Antrodia camphorata. Food Funct. 5: 3224-3232. (SCI)
Wang LC, Lung TY, Kung, YH, Wang JJ, Tsai TY, Wei BL, Pan TM, Lee CL*. 2013. Enhanced anti-obesity activities of red mold dioscorea when fermented using deep ocean water as the culture water. Mar Drugs. 11: 3902-3925.
Wang LC, Kuo IU, Tsai TY, Lee CL*. 2013. Antrodia camphorata-fermented product cultured in deep ocean water has more liver protection against thioacetamide-induced fibrosis. Appl Microbiol Biotechnol. 97: 9955-9967. (SCI)
Lee CL, Wen JY, Hsu YW, Pan TM. 2013. Monascus-fermented yellow pigments monascin and ankaflavin showed antiobesity effect via the suppression of differentiation and lipogenesis in obese rats fed a high-fat diet. J Agric Food Chem. 61: 1493-1500.
Lee CL, Hung YP, Hsu YW, Pan TM. 2013. Monascin and ankaflavin have more anti-atherosclerosis effect and less side effect involving increasing creatinine phosphokinase activity than monacolin K under the same dosages. J Agric Food Chem. 61: 143-150.
Lee CI, Lee CL, Hwang JF, Lee YH, Wang JJ. 2013. Monascus-fermented red mold rice exhibits cytotoxic effect and induces apoptosis on human breast cancer cells. Appl Microbiol Biotechnol. 97: 1269-1278 (SCI)
Wang LC, Wang SE, Wang JJ, Tsai TY, Lin CH, Pan TM, Lee CL*: 2012. In vitro and in vivo comparisons of the effects of the fruiting body and mycelium of Antrodia camphorata against amyloid β-protein-induced neurotoxicity and memory impairment. Appl Microbiol Biotechnol. 94: 1505-1519 (SCI) (NSC-97-2321-B-143-001-MY2)
Lee CL, Pan TM. 2012. Development of Monascus fermentation technology for high hypolipidemic effect. Appl Microbiol Biotechnol. 94: 1449-1459 (SCI)
Lee CL, Kung, YH, Wang JJ, Lung TY, Pan TM: 2011, Enhanced hypolipidemic effect and safety of red mold dioscorea cultured in deep ocean water. J Agric Food Chem. 59: 8199-8207. (SCI) (NSC-98-2313-B-143-002-MY3)
Lee CL, Pan TM: 2011. Red mold fermented products and Alzheimer´s disease. Appl Microbiol Biotechnol. 91: 461-469. (SCI) (NSC-99-2622-B-143-001-CC3)
Wu CL, Kuo YH, Lee CL, Hsu YW, Pan TM: 2011, Synchronous high-performance liquid chromatography with a photodiode array detector and mass spectrometry for the determination of citrinin, monascin, ankaflavin, and the lactone and acid forms of monacolin K in red mold rice. J AOAC Int. 94: 179-190. (SCI)
Lee CL, Kung YH, Wu CL, Hsu YW, Pan TM: 2010, Monascin and ankaflavin act as novel hypolipidemic and high-density lipoprotein cholesterol-raising agents in red mold dioscorea. J Agric Food Chem. 58: 9013–9019. (SCI) (NSC-98-2313-B-143-002-MY3)
Lee CL, Kuo TF, Wu CL, Wang JJ, Pan TM: 2010, Red mold rice promotes neuroprotective sAPPalpha secretion instead of Alzheimer’s risk factors and amyloid beta expression in hyperlipidemic Aβ40-infused rats. J Agric Food Chem. 58: 2230–2238. (SCI)
Lee HC, Lee CL, Pan TM. 2010. A 90-Day toxicity study of Monascus–fermented products including high citrinin level. J Food Sci.75: T91-T97.(SCI)
Wu CL, Lee CL, Pan TM: 2009, Red mold dioscorea has greater anti-hypertensive effect than traditional red mold rice in spontaneously hypertensive rats. J Agric food Chem. 57: 5035-5041. (SCI)
Tsai TY, Chu LH, Lee CL, Pan TM: 2009, Atherosclerosis-preventing activity of lactic acid bacteria-fermented milk-soymilk supplemented with Momordica charantia. J Agric Food Chem. 57: 2065–2071. (SCI)
Lee CL, Wang JJ, Pan TM: 2008, Red mold rice extract represses amyloid beta peptide-induced neurotoxicity via potent synergism of anti-inflammatory and anti-oxidative effect. Appl Microbiol Biotechnol. 79: 829-841. (SCI)
Chen WP, Ho BY, Lee CL, Lee CH, Pan TM: 2008, Red mold rice prevents the development of obesity, dyslipidemia and hyperinsulinemia induced by high-fat diet. Int J Obesity. 32: 1694-1704. (SCI)
Yu CC, Wang JJ, Lee CL, Lee SH, Pan TM: 2008, Safety and mutagenicity evaluation of nanoparticulate red mold rice. J Agric Food Chem. 56: 11038-11048.
Lee CL, Kuo TF, Wang JJ, Pan TM: 2007, Red mold rice ameliorates impairment of memory and learning ability in intracerebroventricular amyloid beta-infused rat via repressing amyloid beta accumulation. J Neurosci Res. 85: 3171-3182. (SCI) (NSC95-2313-B-002-019)
Lee CL, Hung HK, Wang JJ, Pan TM: 2007, Red mold dioscorea has greater hypolipidemic and anti-atherosclerotic effect than traditional red mold rice and unfermented dioscorea in hamster. J Agric Food Chem. 55: 7162-7169. (SCI)
Lee CL, Chen WP, Wang JJ, Pan TM: 2007, A simple and rapid approach for removing citrinin while retaining monacolin K in red mold rice. J Agric food Chem. 55: 11101–11108. (SCI).
Lee CL, Hung HK, Wang JJ, Pan TM: 2007, Improving the ratio of monacolin K to citrinin production of Monascus purpureus NTU 568 under dioscorea medium through the mediation of pH value and ethanol addition. J Agric Food Chem. 55: 6493-6502. (SCI)
Lee CL, Wang JJ, Kuo SL, Pan TM: 2006; Monascus fermentation of dioscorea for increasing the production of cholesterol-lowering agent-monacolin K and antiinflammation agent-monascin. Appl Microbiol Biotechnol. 72: 1254-1262. (SCI)
Lee CL, Tsai TY, Wang JJ, Pan TM: 2006, In vivo hypolipidemic effects and safety of low dosage Monascus powder in a hamster model of hyperlipidemia. Appl Microbiol Biotechnol. 70: 533-540. (SCI)
Lee CL, Wang JJ, Pan TM: 2006; Synchronous analysis method for detection of citrinin and the lactone and acid forms of monacolin K in red mold rice. J AOAC Int. 89: 669-677. (SCI)
Yu CC, Lee CL, Pan TM: 2006; A novel formulation approach for preparation of nanoparticulate red mold rice. J Agric Food Chem. 54: 6845-6851. (SCI)
Chang CY, Lee CL, Pan TM: 2006; Statistical optimization of medium components for the production of Antrodia cinnamomea AC0623 in submerged cultures. Appl Microbiol Biotechnol. 72: 654-661. (SCI)
Wang JJ, Shieh MJ, Kuo SL, Lee CL, Pan TM: 2006, Effect of red mold rice on antifatigue and exercise-related changes in lipid peroxidation in endurance exercise. Appl Microbiol Biotechnol. 70: 247-253. (SCI)
Wang JJ, Lee CL, Pan TM: 2004 Modified mutation method for screening low citrinin-producing strains of Monascus purpureus on rice culture. J Agric Food Chem.; 52: 6977-6982. (SCI)
Wang JJ, Lee CL, Pan TM: Improvement of monacolin K, gamma-aminobutyric acid and citrinin production ratio as a function of environmental conditions of Monascus purpureus NTU 601. J Ind Microbiol Biotechnol. 2003; 30: 669-676. (SCI)
國內外專利
Singapore patent: Composition and method for prevention and treatment of Alzheimer´s disease. Singapore, 200719013-5, 2010/10/29.
Korea patent: Composition and method for prevention and treatment of Alzheimer´s disease. Korea, 10-0959001, 2010/05/1
USA patent: Composition and method for prevention and treatment of Alzheimer´s disease. USA, 11963533, 2012.01
Canada patent: Composition and method for prevention and treatment of Alzheimer´s disease. Canada, 2616971, 2012.07
Japan patent: Pan TM, Lee CL. Composition and method for prevention and treatment of Alzheimer´s disease. Japan, 特許第4974031, 2012.04
Korea patent: Method for manufacturing red mold dioscorea. Korea, 10-1227332, 2013.01.
Japan patent: Method for manufacturing red mold dioscorea.日本,特許第4948609,2012.3
Taiwan patent: Composition and method for prevention and treatment of Alzheimer´s disease. Taiwan, ROC, I341204, 2011.05.01
Taiwan patent: Method for manufacturing red mold dioscorea. Taiwan, ROC, I-350733. 2011/10/21.
European patent: Method for manufacturing a composition for lowering blood lipid and elevating high-density lipoprotein. European Union。EP 2559433 B1
European patent: Composition for Lowering Blood Lipid and Elevating High Density Lipoprotein and Method for Manufacturing the Same. European Union. EP 2559433 2013/11
Korea patent: Composition for Lowering Blood Lipid and Elevating High Density Lipoprotein and Method for Manufacturing the Same. Korea, 10-1420904, 2014/7
Canada patent: Composition for Lowering Blood Lipid and Elevating High Density Lipoprotein and Method for Manufacturing the Same. Canada. CA 2826966.
Singapore patent Composition for Lowering Blood Lipid and Elevating High Density Lipoprotein and Method for Manufacturing the Same. Singapore. SG187997. 2014/11/19
Taiwan patent: Method for promoting the production of catechins, catechols and chlorogenic acid by using deep seawater to promote lactobacillus plantarum to produce catechins, catechols and chlorogenic acid. 2016/1 (I518181)
US Patent Method of treatment of preventing hyperglycemia complication 10,143,678 2018
Taiwan patent: Use of deep seawater lactic acid bacteria fermentation product in preparing composition for reducing body fat formation. 2019/7 (I664971)