Education and Degrees :

    Ph.D., Institute of Microbiology and Biochemistry, National Taiwan University 

Academic and Work Experience:

1. Council board of Taiwan society of deep ocean water resource application    (2014/09- current)

2. Chairman of Department of Life Science, National Taitung University (2013/01-2020/1)

3. Director of Science and Research center of Deep ocean water, National Taitung University (2014/08-2017/7)

4. Deputy director of Sun-Way Biotechnology company. (2017/11~2018/7)

Publication list

1. 1.  Liu CF, Shih TW, Lee CL* Pan TM*. 2024. The Beneficial Role of Lactobacillus paracasei subsp. paracasei NTU 101 in the Prevention of Atopic Dermatitis. Curr. Issues Mol. Biol., 46(3), 2236-2250; https://doi.org/10.3390/cimb46030143

2. Xu TY, Tzeng DY, Lee CL*. 2023. Using Deep Ocean Water in the Fermentation of Antrodia cinnamomea to Boost Magnesium Ion Bioabsorption and Anti-Inflammatory Effects in the Brain of an Alzheimer’s Disease Rat Model. Fermentation, 9(10), 893; https://doi.org/10.3390/fermentation9100893

3. Chang CY, Yang PX, Yu TL, Lee CL*. 2023. Cordyceps cicadae NTTU 868 Mycelia fermented with deep ocean water minerals prevents d-galactose-induced memory deficits by inhibiting oxidative inflammatory factors and aging-related risk factors. Nutrients, 15(8), 1968; https://doi.org/10.3390/nu15081968  (SCI, IF:6.706).

4. Lin CW, Lin CH, Y, Hsu YW, Pan TM*, Lee CL*. 2023. Monascin and ankaflavin prevents metabolic disorder by blood glucose regulatory, hypolipidemic, and anti-inflammatory effects in high fructose and high fat diet-induced hyperglycemic rat. Journal of Functional Foods, 104, 105537 (2023.04) (SCI, IF 5.223) 

5. Lin CW, Lin PY, Y, Hsu YW, Pan TM*, Lee CL*. 2023. Monascus-fermented metabolites repressed amyloid β-peptide-induced neurotoxicity and inflammatory response in in vitro and in vivo studies. Journal of Functional Foods, 104, 105509. (2023.03) DOI: 10.1016/j.jff.2023.105509  (SCI, IF 5.223)

6. Lin CH, Huang HL, Chen YH, Lee CL*. 2022. Deep Ocean Water Minerals Promotes the Growth and Cordycepin Production of Cordyceps militaris Fruiting Bodies through Proteomics Regulation. Fermentation. 2022, 8, 481. https://doi.org/10.3390/fermentation8100481   

7. Lin TA, Ke BJ, Cheng CS, Lee CL*. 2021. Red Quinoa Bran Extract Prevented Alcoholic Fatty Liver Disease via Increasing Antioxidative System and Repressing Fatty Acid Synthesis Factors in mice fed Alcohol Liquid Diet. Molecules. 18;26(22):6973. doi: 10.3390/molecules26226973. (SCI, IF:4.412)

8. Lai JR, Hsu YW, Pan TM*, Lee CL*. 2021. Monascin and ankaflavin of Monascus purpureus prevent alcoholic liver disease through regulating AMPK-mediated lipid metabolism and enhancing anti-inflammatory and anti-oxidative systems. Molecules. 26(20), 6301; https://doi.org/10.3390/molecules26206301 (SCI, IF:4.412)  

9. Lee CY, Lee CL*. 2021. Comparison of the improvement effect of deep ocean water with different mineral composition on the high fat diet-induced blood lipid and nonalcoholic fatty liver disease in a mouse model. Nutrients, 13(5), 1732; doi.org/10.3390/nu13051732 (SCI, IF:5.719)   

10. Wu YZ, Lee CL*. 2021. Cordyceps cicadae NTTU 868 Mycelium with The Addition of Bioavailable Forms of Magnesium from Deep Ocean Water Prevents the Aβ40 and Streptozotocin-induced Memory Deficit via Suppressing Alzheimer’s Disease Risk Factors and Increasing Magnesium Uptake of Brain. Fermentation 7(1), 39 (SCI, IF:3.975).

11. Ke BJ, Lee CL*. 2019. Using submerged fermentation to fast increase N6-(2-hydroxyethyl)-adenosine, adenosine and polysaccharide productions of Cordyceps cicadae NTTU 868. AMB express 9:198 (SCI).

12. Lai JR, Ke BJ, Hsu YW, Lee CL*. 2019. Dimerumic acid and deferricoprogen produced by Monascus purpureus attenuate liquid ethanol diet -induced alcoholic hepatitis via suppressing NF-κB inflammation signalling pathways and stimulation of AMPK-mediated lipid metabolism. J Func Food. 60, 103393 (online)(SCI).

13. Lin TA, Ke BJ, Cheng CS, Wang JJ, Wei BL, Lee CL*. 2019. Red quinoa bran extracts protects against carbon tetrachloride-induced liver injury and fibrosis in mice via activation of antioxidative enzyme systems and blocking TGF-β1 pathway. Nutrients. 11:395 (SCI).

14. Ke BJ, Lee CL*. 2018. Cordyceps cicadae NTTU 868 mycelium prevents CCl4-induced hepatic fibrosis in BALB/c mice via inhibiting the expression of pro-inflammatory and pro-fibrotic cytokines. J Func Food 43: 214-223 (SCI).

15. Lee CL, Pan TM*. 2017. The prevention of Alzheimer's disease and Parkinson’s disease by Monascus purpureus NTU 568-fermented compounds. J Alzheimers Dis Parkinsonism. 7:4 DOI: 10.4172/2161-0460.1000342

16. Hung YP, Lee CL*. 2017. Higher Anti-Liver Fibrosis Effect of Cordyceps militaris-Fermented Product Cultured with Deep Ocean Water via Inhibiting Proinflammatory Factors and Fibrosis-Related Factors Expressions. Mar Drugs. 8:15. pii: E168. doi: 10.3390/md15060168.

17. Wang JJ, Wu CC, Lee CL, Hsieh SL, Chen JB, Lee CI*. 2017. Antimelanogenic, Antioxidant and Antiproliferative Effects of Antrodia camphorata Fruiting Bodies on B16-F0 Melanoma Cells. PLoS One. 12(1) :e0170924. doi: 10.1371/journal.pone.0170924.

18. Lee CL, Wen JY, Hsu YW, Pan TM. The blood lipid regulation of Monascus-produced monascin and ankaflavin via the suppression of low-density lipoprotein cholesterol assembly and stimulation of apolipoprotein A1 expression in the liver. J Microbiol Immunol Infect. 2018 Feb;51(1):27-37. doi: 10.1016/j.jmii.2016.06.003. Epub 2016 Jun 24.

19. Lung TY, Liao LY, Wang JJ, Wei BL, Huang PY, Lee CL*. 2016. Metals of deep ocean water increase the anti-adipogenesis effect of Monascus-fermented product via modulating the monascin and ankaflavin production. Mar Drugs. 14(6). pii: E106. doi: 10.3390/md14060106.  (online) (SCI)

20. Shia YC, Yang SY, Lee DY, Lee CL*. 2016. Increasing Anti-Aβ-induced neurotoxicity ability of Antrodia camphorata-fermented product with deep ocean water supplementary. J Sci Food Agri. 96: 4690–4701 DOI: 10.1002/jsfa.7687 (online) (SCI)

21. Lee CL*. 2015. The advantages of deep ocean water for the development of functional fermentation food. Appl Microbiol Biotechnol. 99: 2523-2531. DOI: 10.1007/s00253-015-6430-7 (SCI)

22. Lee CL, Lin PY, Hsu YW, Pan TM. 2015. Monascus-fermented monascin and ankaflavin improve the memory and learning ability in amyloid β-protein intracerebroventricular-infused rat via the suppression of Alzheimer’s disease risk factors. J Func Food 18:387-399 (SCI)

23. Hung YP, Wang JJ, Wei BL, Lee CL*. 2015. Effect of the salts of deep ocean water on the production of cordycepin and adenosine of Cordyceps militaris-fermented product. AMB express. 5:53. DOI 10.1186/s13568-015-0140-5 (SCI)

24. Lee CI, Wu CC, Hsieh SL, Lee CL, Chang YP, Chang CC, Wang YZ, Wang JJ. 2014. Anticancer effects on human pancreatic cancer cells of triterpenoids, polysaccharides and 1,3-β-d-glucan derived from the fruiting body of Antrodia camphorata. Food Funct. 5: 3224-3232. (SCI)

25. Wang LC, Lung TY, Kung, YH, Wang JJ, Tsai TY, Wei BL, Pan TM, Lee CL*. 2013. Enhanced anti-obesity activities of red mold dioscorea when fermented using deep ocean water as the culture water. Mar Drugs. 11: 3902-3925.

26. Wang LC, Kuo IU, Tsai TY, Lee CL*. 2013. Antrodia camphorata-fermented product cultured in deep ocean water has more liver protection against thioacetamide-induced fibrosis. Appl Microbiol Biotechnol. 97: 9955-9967. (SCI)

27. Lee CL, Wen JY, Hsu YW, Pan TM. 2013. Monascus-fermented yellow pigments monascin and ankaflavin showed antiobesity effect via the suppression of differentiation and lipogenesis in obese rats fed a high-fat diet. J Agric Food Chem. 61: 1493-1500.

28. Lee CL, Hung YP, Hsu YW, Pan TM. 2013. Monascin and ankaflavin have more anti-atherosclerosis effect and less side effect involving increasing creatinine phosphokinase activity than monacolin K under the same dosages. J Agric Food Chem. 61: 143-150.

29. Lee CI, Lee CL, Hwang JF, Lee YH, Wang JJ. 2013. Monascus-fermented red mold rice exhibits cytotoxic effect and induces apoptosis on human breast cancer cells. Appl Microbiol Biotechnol. 97: 1269-1278 (SCI)

30. Wang LC, Wang SE, Wang JJ, Tsai TY, Lin CH, Pan TM, Lee CL*: 2012. In vitro and in vivo comparisons of the effects of the fruiting body and mycelium of Antrodia camphorata against amyloid β-protein-induced neurotoxicity and memory impairment. Appl Microbiol Biotechnol. 94: 1505-1519 (SCI) (NSC-97-2321-B-143-001-MY2)

31. Lee CL, Pan TM. 2012. Development of Monascus fermentation technology for high hypolipidemic effect. Appl Microbiol Biotechnol. 94: 1449-1459 (SCI)

32. Lee CL, Kung, YH, Wang JJ, Lung TY, Pan TM: 2011, Enhanced hypolipidemic effect and safety of red mold dioscorea cultured in deep ocean water. J Agric Food Chem. 59: 8199-8207. (SCI) (NSC-98-2313-B-143-002-MY3)

33. Lee CL, Pan TM: 2011. Red mold fermented products and Alzheimer´s disease. Appl Microbiol Biotechnol. 91: 461-469. (SCI) (NSC-99-2622-B-143-001-CC3)

34. Wu CL, Kuo YH, Lee CL, Hsu YW, Pan TM: 2011, Synchronous high-performance liquid chromatography with a photodiode array detector and mass spectrometry for the determination of citrinin, monascin, ankaflavin, and the lactone and acid forms of monacolin K in red mold rice. J AOAC Int. 94: 179-190. (SCI)

35. Lee CL, Kung YH, Wu CL, Hsu YW, Pan TM: 2010, Monascin and ankaflavin act as novel hypolipidemic and high-density lipoprotein cholesterol-raising agents in red mold dioscorea. J Agric Food Chem. 58: 9013–9019. (SCI) (NSC-98-2313-B-143-002-MY3)

36. Lee CL, Kuo TF, Wu CL, Wang JJ, Pan TM: 2010, Red mold rice promotes neuroprotective sAPPalpha secretion instead of Alzheimer’s risk factors and amyloid beta expression in hyperlipidemic Aβ40-infused rats. J Agric Food Chem. 58: 2230–2238. (SCI)

37. Lee HC, Lee CL, Pan TM. 2010. A 90-Day toxicity study of Monascus–fermented products including high citrinin level. J Food Sci.75: T91-T97.(SCI)

38. Wu CL, Lee CL, Pan TM: 2009, Red mold dioscorea has greater anti-hypertensive effect than traditional red mold rice in spontaneously hypertensive rats. J Agric food Chem. 57: 5035-5041. (SCI)

39. Tsai TY, Chu LH, Lee CL, Pan TM: 2009, Atherosclerosis-preventing activity of lactic acid bacteria-fermented milk-soymilk supplemented with Momordica charantia. J Agric Food Chem. 57: 2065–2071. (SCI)

40.  Lee CL, Wang JJ, Pan TM: 2008, Red mold rice extract represses amyloid beta peptide-induced neurotoxicity via potent synergism of anti-inflammatory and anti-oxidative effect. Appl Microbiol Biotechnol. 79: 829-841. (SCI)

41. Chen WP, Ho BY, Lee CL, Lee CH, Pan TM: 2008, Red mold rice prevents the development of obesity, dyslipidemia and hyperinsulinemia induced by high-fat diet. Int J Obesity. 32: 1694-1704. (SCI)

42. 33.   Yu CC, Wang JJ, Lee CL, Lee SH, Pan TM: 2008, Safety and mutagenicity evaluation of nanoparticulate red mold rice. J Agric Food Chem. 56: 11038-11048.

43. Lee CL, Kuo TF, Wang JJ, Pan TM: 2007, Red mold rice ameliorates impairment of memory and learning ability in intracerebroventricular amyloid beta-infused rat via repressing amyloid beta accumulation. J Neurosci Res. 85: 3171-3182. (SCI) (NSC95-2313-B-002-019)

44. Lee CL, Hung HK, Wang JJ, Pan TM: 2007, Red mold dioscorea has greater hypolipidemic and anti-atherosclerotic effect than traditional red mold rice and unfermented dioscorea in hamster. J Agric Food Chem. 55: 7162-7169. (SCI)

45. Lee CL, Chen WP, Wang JJ, Pan TM: 2007, A simple and rapid approach for removing citrinin while retaining monacolin K in red mold rice. J Agric food Chem. 55: 11101–11108. (SCI).

46. Lee CL, Hung HK, Wang JJ, Pan TM: 2007, Improving the ratio of monacolin K to citrinin production of Monascus purpureus NTU 568 under dioscorea medium through the mediation of pH value and ethanol addition. J Agric Food Chem. 55: 6493-6502. (SCI)

47.  Lee CL, Wang JJ, Kuo SL, Pan TM: 2006; Monascus fermentation of dioscorea for increasing the production of cholesterol-lowering agent-monacolin K and antiinflammation agent-monascin. Appl Microbiol Biotechnol. 72: 1254-1262. (SCI)

48. Lee CL, Tsai TY, Wang JJ, Pan TM: 2006, In vivo hypolipidemic effects and safety of low dosage Monascus powder in a hamster model of hyperlipidemia. Appl Microbiol Biotechnol. 70: 533-540. (SCI)

49.  Lee CL, Wang JJ, Pan TM: 2006; Synchronous analysis method for detection of citrinin and the lactone and acid forms of monacolin K in red mold rice. J AOAC Int. 89: 669-677. (SCI)

50. Yu CC, Lee CL, Pan TM: 2006; A novel formulation approach for preparation of nanoparticulate red mold rice. J Agric Food Chem. 54: 6845-6851. (SCI)

51. Chang CY, Lee CL, Pan TM: 2006; Statistical optimization of medium components for the production of Antrodia cinnamomea AC0623 in submerged cultures. Appl Microbiol Biotechnol. 72: 654-661. (SCI)

52. Wang JJ, Shieh MJ, Kuo SL, Lee CL, Pan TM: 2006, Effect of red mold rice on antifatigue and exercise-related changes in lipid peroxidation in endurance exercise. Appl Microbiol Biotechnol. 70: 247-253. (SCI)

53. Wang JJ, Lee CL, Pan TM: 2004 Modified mutation method for screening low citrinin-producing strains of Monascus purpureus on rice culture. J Agric Food Chem.; 52: 6977-6982. (SCI)

54. Wang JJ, Lee CL, Pan TM: Improvement of monacolin K, gamma-aminobutyric acid and citrinin production ratio as a function of environmental conditions of Monascus purpureus NTU 601. J Ind Microbiol Biotechnol. 2003; 30: 669-676. (SCI)