研究業績

1) Tomita S, Ishida K, Matsumaru D, Hiromori Y, Nagase H,  Nakanishi T*, Excretion and tissue distribution properties of PCB-126 for establishing a bioaccumulation model in mice. BPB Reports. 7, 7-13 (2024).

2) Yamamoto K, Matsumaru D, Ishida K, Endo S, Hiromori Y, Nakanishi T*, Binding profiles of human and mouse complement component 8γ to trisubstituted organometallic compounds. Chem. Biol. Interact. 395, 110998 (2024).

1) Ishida K, Furukawa M, Kunitani M, Yamagiwa R, Hiromori Y, Matsumaru D, Hu J, Nagase H, Nakanishi T*, Novel, highly sensitive, in vivo screening method detects estrogenic activity at low doses of bisphenol A. J. Hazard. Mater. 445, 130461 (2023). 

2) Ogushi S, Nakanishi T, Kimura T*, Cadmium inhibits differentiation of human trophoblast stem cells into extravillous trophoblasts and disrupts epigenetic changes within the promoter region of the HLA-G gene. Toxicol. Sci. 191, 25–33 (2023).

3) Tanaka K, Matsumaru D, Suzuki K, Yamada G, Miyagawa S*, The role of p63 on embryonic external genitalia outgrowth in mice. Dev. Growth. Differ. 65, 132-140 (2023).

4) Ishida K, Takeda K, Takehara Y, Takabayashi T, Miyara M, Sanoh S, Kawai H, Ohta S, Kotake Y*, Methylmercury decreases AMPA receptor subunit GluA2 levels in cultured rat cortical neurons. Biol. Pharm. Bull. 46, 292–300 (2023).

5）石田慶士, 松丸大輔, 中西剛, 化学物質の脳発達への影響を発光で可視化. 光アライアンス 34, 15-18 (2023).

1）中西　剛*, 内分泌かく乱に起因する生殖発生毒性評価の問題点とその将来展望 (Review). ファルマシア 58, 44-49 (2022). 

2）Jia Y, Zhang H, Hu W, Wang L, Kang Q, Liu J, Nakanishi T, Hiromori Y, Kimura T, Tao S, Hu J*, Discovery of contaminants with antagonistic activity against retinoic acid receptor in house dust. J. Hazard. Mater. 426, 127847 (2022). 

3）Ogushi S, Nakanishi T, Kimura T*, Cadmium inhibits forskolin-induced differentiation of human placental BeWo cells.  J. Toxicol. Sci. 47, 309–315 (2022).

4）Ishida K, Matsumaru D, Shimizu S, Hiromori Y, Hisamitsu Nagase H, Nakanishi T*, Evaluation of the estrogenic action potential of royal jelly by genomic signaling pathway in vitro and in vivo. Biol. Pharm. Bull. 45, 1510–1517 (2022).

5）Acebedo AR, Alcantara MC, Nakanishi T, Ogawa T, Yamada G, Suzuki K*, Exposure to the organophosphate pesticide fenitrothion directly induced defects in mouse embryonic external genitalia. Toxicol. Sci. 190, 13-22 (2022).

6) Ishida K, Tatsumi K, Minamigawa Y, Mori K, Matsumaru D, Nagase H, Kanda Y, Takuma K, Nakanishi T*, Neuronal differentiation reporter mice as a new methodology for detecting in vivo developmental neurotoxicity. Biochem. Pharmacol. 206, 115332 (2022) .

7) Zhao M, Murakami S, Matsumaru D, Kawauchi T, Nabeshima YI, Motohashi H*, NRF2 pathway activation attenuates ageing-related renal phenotypes due to α-klotho deficiency. J. Biochem. 171, 579–589 (2022).

1）Haraguchi R*, Yamada G, Murashima A, Matsumaru D, Kitazawa R, Kitazawa S, New Insights into Development of Female Reproductive Tract—Hedgehog-Signal Response in Wolffian Tissues Directly Contributes to Uterus Development. Int. J. Mol. Sci. 22, 1211 (2021).

2）日向泰樹、中井秀郎、中村繁、林祐太郎、水野健太郎、松丸大輔、村嶋亜紀、鈴木堅太郎、山田源. Ⅰ 腎尿路生殖器の発生学 、4 膀胱と尿道の発生. 小児泌尿器科学, 診断と治療社; ISBN：978-4787824226.

3）藤本幸太、松丸大輔、村嶋亜紀、水野健太郎、林祐太郎、鈴木堅太郎、山田源. Ⅰ 腎尿路生殖器の発生学 、7 生殖器の発生（外生殖器の発生）. 小児泌尿器科学, 診断と治療社; ISBN：978-4787824226.

4）Li  Y, Ma H, Chen R, Zhang  H, Nakanishi T, Hu J*, Maternal transfer of 2-ethylhexyl diphenyl phosphate leads to developmental toxicity possibly by blocking the retinoic acid receptor and retinoic X receptor in Japanese Medaka (Oryzias latipes). Environ. Sci. Technol. 55, 5056–5064 (2021).

5）Capitão AMF, Lopes-Marques MS, Páscoa I, Sainath SB, Hiromori Y, Matsumaru D, Nakanishi T, Ruivo R, Santos MM*, Castro LFC*, An ancestral nuclear receptor couple, PPAR-RXR, is exploited by organotins. Sci. Total Environ. 797, 149044 (2021).

6）Onoki T, Izumi Y, Takahashi M, Murakami S, Matsumaru D, Ohta N, Wati SM, Hatanaka N, Katsuoka F, Okutsu M, Yabe Y, Hagiwara Y, Kanzaki M, Bamba T, Itoi E, Motohashi H*, Skeletal muscle-specific Keap1 disruption modulates fatty acid utilization and enhances exercise capacity in female mice. Redox Biol. 43, 101966 (2021).

7）Dungkokkruad P†, Tomita S†, Hiromori Y†, Ishida K, Matsumaru D, Mekada K, Nagase H, Tanaka K, Nakanishi T*, Alginate-coated activated charcoal enhances fecal excretion of 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice, with fewer side effects than uncoated one. J. Toxicol. Sci. 46, 379–389 (2021)

8）Ma H, Ishida K,  Xu C, Takahashi K, Li Y, Zhang C,  Kang Q, Jia Y, Hu W, Matsumaru D, Nakanishi T, Hu J*, Triphenyl phosphate delayed pubertal timing and induced decline of ovarian reserve in mice as an estrogen receptor antagonist. Environ. Pollut. 290. 118096 (2021)

9）Matsumaru D, Motohashi H*, The KEAP1-NRF2 system in healthy aging and longevity (Review). Antioxidants 10, 1929 (2021). 

10）Shiraishi E, Ishida K, Matsumaru D, Ido A, Hiromori Y, Nagase H, Nakanishi T*, Evaluation of the skin-sensitizing potential of Brazilian green propolis. Int. J. Mol. Sci. 22, 13538 (2021). 

1)　Matsumaru D, Motohashi H*, From germ cells to neonates: the beginning of life and the KEAP1-NRF2 system. J. Biochem. 167, 133–138 (2020).

2)　Uruno A†, Matsumaru D†, Ryoke R, Saito R, Kadoguchi S, Saigusa D, Saito T, Saido TC, Kawashima R, Yamamoto M*, Nrf2 suppresses oxidative stress and inflammation in app knock-in Alzheimer’s disease model mice. Mol. Cell. Biol. 40, e00467-19 (2020).　

3)　Yoshida I†, Ishida K†, Yoshikawa H, Kitamura S, Hiromori Y, Nishioka Y, Ido A, Kimura T, Nishikawa JI, Hu J, Nagase H, Nakanishi T*, In vivo profiling of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced estrogenic/anti-estrogenic effects in female estrogen-responsive reporter transgenic mice. J. Hazard. Mater. 385, 121526 (2020). 　

4)　Ogushi S, Ikemoto S, Miura N, Nakanishi T, Kimura T*, Cadmium inhibits all-trans-retinoic acid-induced increase of nitroblue tetrazolium reduction activity and induces metallothionein 1G expression in human acute myelocytic leukemia HL-60 cells. BPB Rep. 3, 34–38 (2020).

5)　Yamamoto  K, Hiromori Y, Matsumaru D, Ishii Y, Takeshita Y, Tsubakihara I, Kimura T, Nagase H, Nakanishi T*, Tri-substituted organotin compounds, but not retinoic acid, are potent ligands of complement component 8γ . J. Toxicol. Sci. 45, 581–587 (2020).

6)　Ogushi S, Yoshida Y, Nakanishi T, Kimura T*, CpG site–specific regulation of metallothionein-1 gene expression. Int. J. Mol. Sci. 21, 5946 (2020).

7）Wati SM, Matsumaru D, Motohashi H*. NRF2 pathway activation by KEAP1 inhibition attenuates the manifestation of aging phenotypes in salivary glands. Redox Biol. 36, 101603 (2020).

8）Yamada Y*, Trakanant S, Nihara J, Kudo T, Seo K, Saeki M, Kurose M, Matsumaru D, Maeda T, Ohazama A*. Gli3 is a Key Factor in the Schwann Cells from Both Intact and Injured Peripheral Nerves. Neuroscience. 432, 229­-239 (2020).

9）Hyuga T, Hashimoto D, Matsumaru D, Kumegawa S, Asamura S, Suzuki K, Katayama KI, Nakamura S, Nakai H, Yamada G*. Evaluation of surgical procedures of mouse urethra by visualization and the formation of fistula. Sci. Rep. 10, 18251 (2020).

10）Okazaki K, Anzawa H, Liu Z, Ota N, Kitamura H, Onodera Y, Alam MM, Matsumaru D, Suzuki T, Katsuoka F, Tadaka S, Motoike I, Watanabe M, Hayasaka K, Sakurada A, Okada Y, Yamamoto M, Suzuki T, Kinoshita K, Sekine H*, Motohashi H*. Enhancer remodeling promotes tumor-initiating activity in NRF2-activated non-small cell lung cancers. Nat. Commun. 11, 5911 (2020).

11）Oishi T, Matsumaru D, Ota N, Kitamura H, Zhang T, Honkura Y, Katori Y, Motohashi H*, Activation of the NRF2 pathway in Keap1-knockdown mice attenuates progression of age-related hearing loss. NPJ. Aging. Mech. Dis. 6, 14 (2020). 

1)　Kimura T*, Hosaka T, Nakanishi T, Aozasa O, Long-term cadmium exposure enhances metallothionein-1 induction after subsequent exposure to high concentrations of cadmium in P1798 mouse lymphosarcoma cells. J. Toxicol. Sci. 44, 309–316 (2019).

2)　Hu W, Jia Y, Kang Q, Peng H, Ma H, Zhang S, Hiromori Y, Kimura T, Nakanishi T, Zheng L, Qiu Y, Zhang Z, Wan Y, Hu J*, Screening of house dust from chinese homes for chemicals with liver X receptors binding activities and characterization of atherosclerotic activity using an in vitro macrophage cell line and ApoE-/- mice. Environ. Health Perspect. 127, 117003 (2019).

3)　Fonseca ESS†, Hiromori Y†, Kaite Y, Ruivo R, Franco JN, Nakanishi T*, Santos MM*, Castro LFC*, An orthologue of the retinoic acid receptor (RAR) is present in the Ecdysozoa Phylum Priapulida. Genes (Basel) 10, 985 (2019).

4)　梶本みずき, IPULAN Lerrie Ann, 松丸大輔, 橋本大輝, 日向泰樹, 鈴木堅太郎, 山田 源*, 外生殖器亀頭海綿体における性差構築過程の解析. 和歌山医学 70, 54–60 (2019).

1)　Nishioka Y, Tamai K, Onda M, Hiromori Y, Kimura T, Hu J, Nagase H, Nakanishi T*, Potential interference of oil vehicles on genital tubercle development during the fetal period in ICR mice. Biol. Pharm. Bull. 41, 266–­­271 (2018).

2)　Törner K, Nakanishi T, Matsuura T, Kato Y, Watanabe H*, Genomic integration and ligand-dependent activation of the human estrogen receptor α in the crustacean Daphnia magna. PLoS One 13, e0198023 (2018).

3)　Capitão AMF, Lopes-Marques MS, Ishii Y, Ruivo R, Fonseca ESS, Páscoa I, Jorge RP, Barbosa MAG, Hiromori Y, Miyagi T, Nakanishi T, Santos MM*, Castro LFC*, Evolutionary Exploitation of Vertebrate Peroxisome Proliferator-Activated Receptor γ by Organotins. Environ. Sci. Technol. 52, 13951–13959 (2018).

1)　Zhang Z, Hu Y, Guo J, Yu T, Sun L, Xiao X, Zhu D*, Nakanishi T, Hiromori Y, Li J, Fan X, Wan Y, Cheng S, Li J, Guo X, Hu J*, Fluorene-9-bisphenol is anti-oestrogenic and may cause adverse pregnancy outcomes in mice. Nat. Commun. 8, 14585 (2017).

 　➡ 本論文は、イギリスの一般読者向け科学雑誌New Scientistの「Daily News（2017年2月28日付）」およびNature Asiaの「注目のハイライト（2017年3月1日付）」 に取り上げられた。

2)　Ido A†, Hiromori Y†, Meng L, Usuda H,  Nagase H, Yang M, Hu J*, Nakanishi T*, Occurrence of fibrates and their metabolites in source and drinking water in Shanghai and Zhejiang, China, Sci. Rep. 7, 45931 (2017).

3)　 Shiraishi E, Ido A, Hiromori Y, Tanaka K, Kimura T, Nagase H, Nakanishi T*, Utility of murine dendritic cell line DC2.4 for in vitro assay of skin-sensitization potential, Fundam. Toxicol.Sci. 4, 121–126 (2017).

4)　Hu W, Gao F, Zhang H, Hiromori Y, Arakawa S, Nagase H, Nakanishi T, Hu J*, Activation of peroxisome proliferator-activated receptor γ and disruption of progesterone synthesis of 2-ethylhexyl diphenyl phosphate in human placental choriocarcinoma cells: Comparison with triphenyl phosphate. Environ. Sci. Technol. 51, 4061–4068 (2017).

1)　 Hiromori Y, Yui H, Nishikawa J, Nagase H, Nakanishi T*, Organotin compounds cause structure-dependent induction of progesterone in human choriocarcinoma Jar cells. J. Steroid Biochem. Mol. Biol.155, 190–198 (2016).

2)　 Aoki A, Fujitani K, Takagi K, Kimura T, Nagase H, Nakanishi T*, Male hypogonadism causes obesity associated with impairment of hepatic gluconeogenesis in mice. Biol. Pharm. Bull. 39, 587–592 (2016).

3)　Al-Soudy AS, Nakanishi T, Mizuno S, Hasegawa Y, Shawki HH, Katoh MC, Basha WA, Ibrahim AE, El-Shemy HA, Iseki H, Yoshiki A, Hiromori Y, Nagase H, Takahashi S, Oishi H*, Sugiyama F, Germline recombination in a novel Cre transgenic line, Prl3b1-Cre mouse. Genesis 54, 389–397 (2016).

4)　 Hiromori Y, Ido A, Aoki A, Kimura T, Nagase H, Nakanishi T*, Ligand activity of group 15 compounds possessing triphenyl substituent for the RXR and PPARγ nuclear receptors. Biol. Pharm. Bull. 39, 1596–1603 (2016).

1)　Ido A, Niikawa M, Ishihara S, Sawama Y, Nakanishi T, Monguchi Y, Sajiki H, Nagase H*,  Practical remediation of the PCB-contaminated soils, J. Environ. Health Sci. Eng. 13, 9 (2015).

2)      Harada S, Hiromori Y, Nakamura S, Kawahara K, Fukakusa S, Maruno T, Noda M, Uchiyama S, Fukui K, Nishikawa J, Nagase H, Kobayashi Y, Yoshida T*, Ohkubo T, Nakanishi T*, Structural basis for PPARγ transactivation by endocrine-disrupting organotin compounds. Sci. Rep. 5, 8520 (2015).

3)      Zhang H, Zhang Z, Nakanishi T, Wan Y, Hiromori Y, Nagase H, Hu J*, Structure-dependent activity of phthalate esters and phthalate monoesters binding to human constitutive androstane receptor. Chem. Res. Toxicol. 28, 1196–1204 (2015).

4)      Hiromori Y, Aoki A, Nishikawa J, Nagase H, Nakanishi T*, Transactivation of the human retinoid X receptor by organotins: use of site-directed mutagenesis to identify critical amino acid residues for organotin-induced transactivation. Metallomics. 7, 1180­­­­­­­­­–1188 (2015).

5)   Kimura T*, Onodera A, Okumura F, Nakanishi T, Itoh N, Chromium (VI)-induced transformation is enhanced by Zn deficiency in BALB/c 3T3 cells. J. Toxicol. Sci. 40, 383–387 (2015).