Guinevere Eden

B.Sc. -- University College London, 1989, Physiology

D. Phil. -- Oxford University, 1993, Physiology

Guinevere Eden received her D.Phil. in Physiology from Oxford University and has since focused on the application of functional neuroimaging techniques to study the neural basis of developmental dyslexia. The Center for the Study of Learning is funded by the National Institutes of Child Health and Human Development, National Institutes of Health. In collaboration with the Science of Learning Center on Visual Language and Visual Learning (VL2) at Gallaudet University and with Wake Forest School of Medicine, the CSL's research focuses on the neural representation of reading and how it may be altered in individuals with developmental disorders or altered early sensory experience. Further, she and her colleagues are researching how reading is impacted by instructions or mode of communication and are utilizing functional MRI to study the neurobiological correlates of reading remediation.

Dr. Eden teaches students enrolled in the graduate neuroscience program. She is past-president of the International Dyslexia Association and serves on the editorial boards of the Annals of Dyslexia, Dyslexia, Brain and Language, Developmental Cognitive Neuroscience and Human Brain Mapping. She has served as a permanent member of a standing NIH Study Section and as ad-hoc member and chair for special emphasis panels.

Dr. Eden has also authored several articles for Understood.org, which provides information and support to parents of children with learning and attention issues.

Journal Articles

Ashburn, S.M., Flowers, D.L., Napoliello, E.M., & Eden, G.F. (2019). Cerebellar function in children with and without dyslexia during single word processing. Human Brain Mapping, 1-19.
Evans, T.M., Flowers, D.L., Luetje, M.M., Napoliello, E., Eden, G.F. (2016). Functional neuroanatomy of arithmetic and word reading and its relationship to age. Neuroimage, 143: 304-315.
Turesky, T.K., Turkeltaub, P.E., Eden, G.F. (2016). An Activation Likelihood Estimation Meta-Analysis Study of Simple Motor Movements in Older and Young Adults. Front Aging Neurosci, 8: 238.
Glezer, L. S., Eden, G. J., Jiang, X., Luetje, M., Napoliello, E., Kim, J., & Riesenhuber, M. (2016). Uncovering phonological and orthographic selectivity across the reading network using fMRI-RA. NeuroImage, 138, 248–256. https://doi.org/10.1016/j.neuroimage.2016.05.072
Purcell, J.J., Jiang, X., Eden, G.F. (2016). Shared orthographic neuronal representations for spelling and reading. Neuroimage, 147: 554-567. PMID: 28011250.
Krafnick, A.J., Tan, L.-H., Flowers, D.L., Luetje, M.M., Napoliello, E.M., Siok, W.-T., Perfetti, C., Eden, G.F. (2016). Chinese character and English word processing in children's ventral occipitotemporal cortex: fMRI evidence for script invariance. Neuroimage, 133: 302-312.
Olulade, O.A., Jamal, N.I., Koo, D.S., Perfetti, C.A., LaSasso, C., Eden, G.F. (2016). Neuroanatomical evidence in support of the bilingual advantage theory. Cerebral Cortex, 26(7):3196-3204.
Olulade, O.A., Flowers, D.L., Napoliello, E.M., Eden, G.F. (2015). Dyslexic children lack word selectivity gradients in occipito-temporal and inferior frontal cortex. Neuroimage Clinical, 7:742-54.
Evans, T.M., Flowers, D.L., Napoliello, E.M., Olulade, O.A., Eden, G.F. (2014). The functional anatomy of single-digit arithmetic in children with developmental dyslexia. Neuroimage, 101(1):644-52.
Olulade, O.A., Koo, D.S., LaSasso, C.J., Eden, G.F. (2014). Neuroanatomical profiles of deafness in the context of native language experience. Journal of Neuroscience, 34(16):5613-20.
Krafnick, A.J., Flowers, D.L., Luetje, M.M., Napoliello, E.M., Eden, G.F. (2014). An investigation into the origin of anatomical differences in dyslexia. Journal of Neuroscience, 34(3):901-8.
Evans, T.M., Flowers, D.L., Napoliello, E.M., Eden, G.F. (2014). Sex-specific gray matter volume differences in females with developmental dyslexia. Brain Structure and Function, 219(3):1041-54.
Olulade, O.A., Napoliello, E.M., Eden, G.F. (2013). Abnormal visual motion processing is not a cause of dyslexia. Neuron, 79(1):180-90.
Olulade, O.A., Flowers, D.L., Napoliello, E.M., Eden, G.F. (2013). Developmental differences for word processing in the ventral stream. Brain and Language, 125(2):134-45.
Weisberg, J., Koo, D.S., Crain, K.L., Eden, G.F. (2012). Cortical plasticity for visuospatial processing and object recognition in deaf and hearing signers. Neuroimage, 60(1):661-72.
Purcell, J.J., Turkeltaub, P.E., Eden, G.F., Rapp, R. (2011). Examining the central and peripheral processes of written word production through meta-analysis. Frontiers in Psychology, 2:239.
Cramer, S.C., Sur, M., Dobkin, B.H., O'Brien, C., Sanger, T.D., Trojanowski, J.Q., Rumsey, J.M., Hicks, R., Cameron, J., Chen, D., Chen, W.G., Cohen, L.G., deCharms, C., Duffy, C.J., Eden, G.F., Fetz, E.E., Filart, R., Freund, M., Grant, S.J., Haber, S., Kalivas, P.W., Kolb, B., Kramer, A.F., Lynch, M., Mayberg, H.S., McQuillen, P.S., Nitkin, R., Pascual-Leone, A., Reuter-Lorenz, P., Schiff, N., Sharma, A., Shekim, L., Stryker, M., Sullivan, E.V., Vinogradov, S. (2011). Harnessing neuroplasticity for clinical applications. Brain, 134(Pt 6):1591-609.
Jamal, N.I., Piche, A.W., Napoliello, E.M., Perfetti, C.A., Eden, G.F. (2012). Neural basis of single-word reading in Spanish-English bilinguals. Human Brain Mapping, 33(1):235-45.
Purcell, J.J., Napoliello, E.M., Eden, G.F. (2011). A combined fMRI study of typed spelling and reading. Neuroimage, 55(2):750-62.
Krafnick, A.J., Flowers, D.L., Napoliello, E.M., Eden, G.F. (2011). Gray matter volume changes following reading intervention in dyslexic children. Neuroimage, 57(3):733-41.
Koo, D., Crain, K., LaSasso, C., Eden, G.F. (2008). Phonological awareness and short term memory in hearing and deaf individuals of different communication backgrounds. Annals of the New York Academy of Sciences, 1145:83-99.
Turkeltaub, T.E., Flowers, D.L., Lyon, L.G. and Eden, G.F. (2008). Development of ventral stream representations for single letters. Annals of the New York Academy of Sciences, 1145:13-29.
Eden, G.F., Vaidya, C. (2008). ADHD and developmental dyslexia: Two pathways leading to impaired learning. Annals of the New York Academy of Sciences, 1145:316-27.
Maisog, J.M., Einbinder, E.R., Turkeltaub, P.E., Flowers, D.L., Eden, G.F. (2008). A meta-analysis of reading in developmental dyslexia. Annals of the New York Academy of Sciences, 1145:237-59.
Given, B.K., Wasserman, J.D., Chari, S.A., Beattie, K., Eden, G.F. (2008). A randomized, controlled study of computer-based intervention in middle school struggling readers. Brain and Language, 106(2):83-97.
Leonard, C.M., Eckert, M.A., Given, B.K., Berninger, V.W., Eden, G.F. (2006). Individual differences in anatomy predict reading and oral language impairments in children. Brain, 129(12):3329-42.
Chait, M., Eden, G.F., Poeppel, D., Simon, J.Z., Hill, D.F., Flowers, D.L. (2006). Delayed detection of tonal targets in background noise in dyslexia. Brain and Language, PMID: 16887180.
Howard, J.H., Howard, D., Japikse, K.A., Eden, G.F. (2006). Dyslexics are impaired on implicit higher-order sequence learning, but not on implicit spatial context learning. Neuropsychologia, 44(7), 1131-44.
Tan, L.H., Spinks, J.A., Eden, G.F., Perfetti, C.C., Siok, W.T. (2005). Reading depends on writing in Chinese. Proceedings of the National Academy of Sciences, (24) 8781-8785
Dietz, N.A.E., Jones, K. M., Gareau, L., Zeffiro, T. A., Eden, G.F. (2005). The role of the left posterior fusiform cortex in phonological decoding. Human Brain Mapping, 26(2):81-93.
Eden, G.F., Jones, K.M., Cappell, K., Gareau, L., Wood, F.B., Zeffiro, T.A., Dietz, N.A.E., Agnew, J.A., Flowers, D.L. (2004). Neural changes following remediation in adult developmental dyslexia, Neuron, 44(3), 411-422.
Agnew, J.A., Zeffiro, T.A., Eden, G.F. (2004). Left hemisphere specialization for the control of variable rate voluntary movement. Neuroimage, 22(1):289-303.
Turkeltaub, P.E., Flowers, D.L., Verbalis, A., Miranda, M., Gareau, L., Eden, G.F. (2004). The neural basis of hyperlexic reading: an fMRI case study. Neuron, 41, pp 1-20
Flowers, D.L., Jones, K., Noble, K., VanMeter, J.W., Zeffiro, T.A., Wood, F.B., Eden, G.F. (2004). Attention to single letters activates left extrastriate cortex. Neuroimage, 21(3):829-39.
Lin, F.-H., McIntosh, A.R., Agnew, J., Eden, G.F., Zeffiro, T.A., Belliveau, J.W. (2003). Multivariate analysis of neuronal interactions in the generalized partial least squares framework: Simulations and empirical studies. Neuroimage, 20(2):625-42
Agnew, J., Dorn, D., Eden, G.F. (2004). Effect of intensive training on rapid temporal processing. Brain and Language, 88 (1), 21-25.
Turkeltaub, P.E., Gareau, L., Flowers, D.L., Zeffiro, T.A., Eden, G.F. (2003). Development of neural mechanisms for reading. Nature Neuroscience, 6(7):767-73.
Eden, G.F., Stein, J.F., Wood, H.M., Wood, F.B. (2003). Clock drawing in reading disabled children. Journal of Learning Disabilities, 36(3):216-28.
Turkeltaub, P.E., Eden, G.F., Jones, K.M., Zeffiro, T.A. (2002). Meta-analysis of the functional neuroanatomy of single-word reading: method and validation. Neuroimage, 16(3 Pt 1):765-80.
Joseph, J. E., Noble, K., Eden, G.F. (2001). The neurobiological basis for reading. Journal of Learning Disabilities, 34(6):566-79.
Zeffiro, T. Eden, G. (2000). The neural basis of developmental dyslexia. Annals of Dyslexia, 50:3-30.
Eden, G.F., Joseph, J.E., Brown, H.E., Brown, C.P., Zeffiro, T.A. (1999). Utilizing hemodynamic delay and dispersion to detect fMRI signal change without auditory interference: the Behavioral Interleaved Gradients Technique. Magnetic Resonance in Medicine, 41(1):13-20.
Zeffiro, T.A., Eden, G.F., Woods, R.P., VanMeter, J.W. (1997). Intersubject analysis of fMRI data using spatial normalization. Advances in Experimental Medicine and Biology, 413:235-40.
Eden, G.F., Zeffiro, T.A. (1996). The visual deficit theory of developmental dyslexia. Neuroimage, 4(3):S108-S117.
Eden, G.F., VanMeter, J.W., Rumsey, J.W., Maisog, J., Zeffiro, T.A. (1996). Abnormal processing of visual motion in dyslexia revealed by functional brain imaging. Nature, 348:66-9.
Eden, G.F., Stein, J.F., Wood, H.M., Wood, F.B. (1996). Visuospatial judgment in reading disabled and normal children. Perceptual and Motor Skills, 82:155-77.
Hilton, M., Ogden, T., Hattery, D., Eden, G., Jawerth, B. (1996). Wavelet denoising of functional MRI data. Wavelets in Biology and Medicine. A. Aldroubi and M. Unser, CRC Press: 93-112.
Eden, G.F., Stein, J.F., Wood, H.M., Wood, F.B. (1995). Temporal and spatial processing in reading disabled and normal children. Cortex, 31:451-68.
Eden, G.F., Stein, J.F., Wood, H.M., Wood, F.B. (1994). Differences in eye movements and reading problems in dyslexic and normal children. Vision Research, 34(10):1345-58.
Eden, G. F., Stein, J.F., Wood, M.H., Wood, F.B. (1993). Dyslexia: a study of preserved and impaired visuospatial and phonological functions. Annals of the New York Academy of Sciences, 682:335-8.

Book Chapters and Invited Articles

Eden, G.F., Olulade, O.A., Evans, T.M., Krafnick, A.J., Alkire, D.R. (2016). Developmental dyslexia. In G. Hickok and S. Small (Eds.), Neurobiology of Language. Elsevier: Oxford, UK.
Eden, G.F., Olulade, O.A., Evans, T.M., Krafnick, A.J., Alkire, D.R. (2015). Imaging studies of reading and reading disability. In A.W. Toga (Ed.), Brain Mapping: An Encyclopedic Reference. Elsevier: Oxford, UK.
Eden, G.F., Flowers, D.L (2008). Developmental dyslexia. In L.S. Squire, T. Albright, F. Bloom, F. Gage, N. Spitzer (Eds.), New Encyclopedia of Neuroscience. Elsevier: Oxford, UK.
Eden, G.F., Flowers, D.L (2008) Developmental dyslexia. In C A. Nelson, M. Luciana, Handbook of Developmental Cognitive Neuroscience. MIT Press.
Turkeltaub, P.E., Weisberg, J., Flowers, D.L., Basu, D., Eden, G.F. (2005) The neurobiological basis of reading: A special case of skill acquisition. In H. Catts, A. Kahmi (Eds.), The Connections Between Language and Reading Disabilities, pp103-130. Mahway, NJ: Erlbaum.
Eden, G.F., Zeffiro, T.A. (1999). Techniques for functional neuroimaging: Functional magnetic resonance imaging (fMRI). In J.M. Rumsey, M. Ernst (Eds.), The Foundation and Future of Functional Neuroimaging in Child Psychiatry. Cambridge University Press.
Eden, G.F., Zeffiro, T.A. (1999). Functional neuroimaging in developmental dyslexia. In P. Bandettini, C. Moone (Eds.), Medical Radiology: Diagnostic Imaging and Radiation Oncology. Springer-Verlag: Berlin.
Eden, G F., Zeffiro, T.A. (1998). Looking beyond the reading difficulties in dyslexia, a vision deficit. In B.M. Jubilan (Ed.), Biopsychology 98/99 (pp. 192-196). Guilford: Dushkin/McGraw-Hill.
Rumsey, J.M., Eden, G.F. (1998). Functional neuroimaging of developmental dyslexia: Regional cerebral blood flow in dyslexic men. In B. Shapiro, P J. Accardo, A.J. Capute (Eds.) Specific Reading Disability: A View of the Spectrum (pp. 35-32). York Press: Timonium, MD.
Hilton, M., Ogden, T., Hattery, D., Eden, G.F., Jawerth, B. (1996). Wavelet denoising of functional MRI data. In A. Aldroubi, M. Unser (Eds.), Wavelets in Biology and Medicine (pp. 93-112). CRC Press.
Eden, G.F., Zeffiro, T.A. (1996). Sensitivity of PET and fMRI in the detection of task related brain activity: implications for the study of brain development. In G R. Lyon, J. Rumsey, N. Krasnegor, R.W. Thatcher (Eds.), Developmental Neuroimaging: Mapping the Development of Brain and Behavior (pp. 77-87). Academic Press: San Diego, CA.
Eden, G.F., VanMeter, J.W., Rumsey, J.M., Zeffiro, T.A. (1996). Looking beyond the reading problems in developmental dyslexia: visualising the visual processing deficits. NIH Research, 8, 31-35.
Eden, G.F., Stein, J.F., Wood, F.B. (1993). Visuospatial ability and language processing in reading disabled and normal children. In S.F. Wright, R. Groner (Eds.), Studies in Visual Information Processing: Facets of dyslexia and its remediation (pp. 321-335). Elsevier: North-Holland.

Reviews and Comments

Eden, G.F., Moats, L. (2002). The role of neuroscience in the remediation of students with dyslexia. Nature Neuroscience, 5 Suppl:1080-4.
Zeffiro, T.A., Eden, G.F. (2001). The cerebellum and dyslexia: perpetrator or innocent bystander? Trends in Neurosciences, 24(9):512-3.
Eden, G.F., Zeffiro, T.A. (2000). The possible relationship between visual deficits and dyslexia: Examination of a critical assumption - Comments on Skottun and Parke. Journal of Learning Disabilities, 32(5):378.
Zeffiro, T.A., Eden, G.F. (2000). What's the matter? White matter? Neuron, 25(2):257-9.
Eden, G.F., Zeffiro, T.A. (1998). Neural systems affected in developmental dyslexia revealed by functional neuroimaging. Neuron, 21:279-282.
Eden, G.F. (1996). Verbal and visual problems in reading disabled and normal children - a response to Dr. Cherkes-Julkowski. Journal of Learning Disabilities, 29(1):8.
Eden, G.F., Stein, J.F., Wood, H.M., Wood, F.B. (1995). Verbal and visual problems in reading disabled and normal children. Journal of Learning Disabilities, 28(5):272-290.