Library
2M compounds have been collected and opened for screening.
GRC collection
The collected compounds were reformatted into wells of 384- and 1536-well plates and were stored at 1 mM in 100% DMSO.
The collected compounds come from two sources: commercial and collaborative collection mainly from research institutes or collaborators in Taiwan. Current library contains mostly small molecular compounds with drug‐like properties followed an extended Lipinski’s rules of five (RO5). RO5 is derived from analysis of successfully compounds in drug discovery and has been adopted as criteria for drug candidate development for medicinal chemistry.
The extended RO5 criteria are:
Partition coefficient logP in ‐0.4 to +5.6 range
Molar refractivity from 40 to 130
Molecular weight from 160 to 500
Number of atoms from 20 to 70 (includes H‐bond donors [e.g.; H and NH] and H‐bond acceptors [e.g.; N and O])
Polar surface area no greater than 140 Ǻ2
Library Preparation
The collected compounds were reformatted into wells of 384- and 1536-well plates and were stored at 1 mM in 100% DMSO.
