Core Technology & Facilities

The goal of assay development focuses on miniaturizing the assays for 384- and 1536-well plates and on the delivery of robust and well validated assays for HTS.

The ultra high-throughput screening (uHTS) system at GRC has unsurpassed screening capacity,  accuracy, and flexibility.

Current library contains mostly small molecular compounds with drug‐like properties followed an extended Lipinski’s rules of five (RO5). The collected compounds were reformatted into wells of 384- and 1536-well plates and stored at 1 mM in 100% DMSO.

The  informatics capabilities of the uHTS lab include data storage and analysis. Compound and screen data are deposited in databases with applications tailored for statistics and visualization.

The fluorescence or luminescence signal of a plate is read by the ViewLux imager and PHERAStar plate reader. 

Versatile liquid handling systems fulfill the needs of transfer liquids between tubes, 96-, 384-, and 1536-well plates