代表性研究成果
2026｜Nature Communications
Corylin promotes healthy aging via RAGA–mTOR suppression and sex-dependent activation of SIRT3
研究涵蓋自然老化、壽命與健康壽命、RAGA–mTOR、ESR1–SIRT3、多器官多體學及性別差異。鄭淑方同學名列第一作者，主導長期動物研究。
2022｜Nature Communications
研究以長期高脂飲食小鼠解析 corylin 對代謝健康及壽命的作用，建立天然物健康老化研究平台。曾煒哲同學名列第一作者，之後獲全額獎學金赴 The University of Texas at Austin 攻讀博士。
這些成果呈現從天然物功能篩選、AI 輔助多體學整合、機制驗證與長期動物研究到國際發表的完整研究路徑。
代表著作
1. Cheng SF, Lin YT, Wang TH, Leu YL, Hsia KC, Lee WC, Feng CH, Kuo CH, Yang SH, Wang MC, Liu CY, Hu PC, Hsieh YC, Yang CW, Wang SH, Yu JS, Chen CY, Chen CC*. Corylin promotes healthy aging via RAGA-mTOR suppression and sex-dependent activation of SIRT3. (2026) Nature Communications. doi: 10.1038/s41467-026-74184-9.
2. Liu YY, Chen CC(co-first), Kuo CH, Leu YL, Wang SH. Beneficial Effects of Corylin on Metabolic Dysfunction-Associated Fatty Liver Disease. (2026) Antioxid Redox Signal. 44(16-18):910-927. doi: 10.1177/15230864261443781.
3. Chen CC, Wang TH, Leu YL, Chan CW, Chen YX, Chu TD, Chen CY. Magnolol suppresses TKI-resistant EGFR-mutant lung cancer by inhibiting EGFR and AXL-cMyc. (2026) Eur J Pharmacol 28;1016:178607. doi: 10.1016/j.ejphar.2026.178607. Epub 2026 Jan 27
4. Chen CC, Chen CY, Chou LF, Yeh CT, Liu YT, Chu YD, Lin HW, Chen KY, Yu CC, Wang TH. Corylin attenuates oral squamous cell carcinoma progression through c-Myc inhibition. (2025) J Dent Sci. 20(4):2322-2331. doi: 10.1016/j.jds.2025.04.014.
5. Leu YL, Cheng SF, Wang TH, Feng CH, Chen YJ, Hsieh YC, Lan YH, Chen CC*. Increasing DNA damage sensitivity through corylin-mediated inhibition of homologous recombination. (2024) Biomed Pharmacother. 11;176:116864. doi: 10.1016/j.biopha.2024.116864
6. Chang TY, Lin MS, Chen CC (co-first), Leu YL, Wang SH. Isoxanthohumol reduces neointimal hyperplasia through the apelin/AKT pathway. (2024) Biochim Biophys Acta Mol Basis Dis.1870(4):167099. doi: 10.1016/j.bbadis.2024.167099. Epub 2024 Feb 28. PMID: 38428686.
7. Chen CC, Chen CY, Yeh CT, Liu YT, Leu YL, Chuang WY, Shih YH, Chou LF, Shieh TM, Wang TH. Corylin Attenuates CCl4-Induced Liver Fibrosis in Mice by Regulating the GAS6/AXL Signaling Pathway in Hepatic Stellate Cells. (2023) Int J Mol Sci. doi: 10.3390/ijms242316936
8. Wang TH., Tseng WC., Leu YL., Chen CY., Lee WC., Chi YC., Cheng SF., Lai CY., Kuo CH., Yang SL., Yang SH., Shen JJ., Feng CH., Wu CC., Hwang TL., Wang CJ., Wang SH., Chen CC*. The flavonoid corylin exhibits lifespan extension properties in mouse. (2022) Nature Communications doi:10.1038/s41467-022-28908-2
9. Chen CC, Chen CY, Cheng SF, Shieh TM, Leu YL, Chuang WY, Liu KT, Ueng SH, Shih YH, Chou LF, Wang TH. Hydroxygenkwanin Increases the Sensitivity of Liver Cancer Cells to Chemotherapy by Inhibiting DNA Damage Response in Mouse Xenograft Models. (2021) Int J Mol Sci. 9;22(18):9766. doi: 10.3390/ijms22189766
10. Wang TH, Chen CC(co-first), Leu YL, Lee YS, Lian JH, Hsieh HL, Chen CY. Palbociclib induces DNA damage and inhibits DNA repair to induce cellular senescence and apoptosis in oral squamous cell carcinoma. (2021) J Formos Med Assoc. 18:S0929-6646(20)30609-4. doi: 10.1016/j.jfma.2020.12.009
11. Tseng WC, Chen CY, Chern CY, Wang CA, Lee WC, Chi YC, Cheng SF, Kuo YT, Chiu YC, Tseng ST, Lin PY, Liou SJ, Li YC, Chen CC*. Targeting HR Repair as a Synthetic Lethal Approach to Increase DNA Damage Sensitivity by a RAD52 Inhibitor in BRCA2-Deficient Cancer Cells. (2021) Int J Mol Sci. Apr 23;22(9):4422. doi: 10.3390/ijms22094422.
12. Chen CC, Kuo CH, Leu YL, Wang SH. Corylin reduces obesity and insulin resistance and promotes adipose tissue browning through SIRT-1 and β3-AR activation. (2021) Pharmacol Res. 27:105291. doi: 10.1016/j.phrs.2020.105291
13. Chen CY, Fang JY, Chen CC(co-first), Chuang WY, Leu YL, Ueng SH, Wei LS, Cheng SF, Hsueh C, Wang TH. 2-O-Methylmagnolol, a Magnolol Derivative, Suppresses Hepatocellular Carcinoma Progression via Inhibiting Class I Histone Deacetylase Expression. (2020) Frontiers in Oncology 10:1319. doi: 10.3389/fonc.2020.01319
14. Chen CY, Chen CC(co-first), Chuang WY, Leu YL, Ueng SH, Hsueh C, Yeh CT, Wang TH. Hydroxygenkwanin Inhibits Class I HDAC Expression and Synergistically Enhances the Antitumor Activity of Sorafenib in Liver Cancer Cells. (2020) Frontiers in Oncology 25;10:216. doi: 10.3389 /fonc.2020.00216
15. Chen CC, Li HY, Leu YL, Chen YJ, Wang CJ, Wang SH. Corylin Inhibits Vascular Cell Inflammation, Proliferation and Migration and Reduces Atherosclerosis in ApoE-Deficient Mice. (2020) Antioxidants 25;9(4) doi: 10.3390/antiox9040275
16. Wang TH, Chen CC(co-first), Huang KY, Shih YM, Chen CY. High levels of EGFR prevent sulforaphane-induced reactive oxygen species-mediated apoptosis in non-small-cell lung cancer cells. (2019) Phytomedicine 64:152926. doi: 10.1016/j.phymed.2019.152926
17. Kuo CH, Leu YL, Wang TH, Tseng WC, Feng CH, Wang SH, Chen CC*. A novel DNA repair inhibitor, diallyl disulfide (DADS), impairs DNA resection during DNA double-strand break repair by reducing Sae2 and Exo1 levels. (2019) DNA repair 82:102690 doi: 10.1016/j.dnarep.2019.102690
18. Chen CC, Lee TY, Leu YL, Wang SH. Pigment epithelium-derived factor inhibits adipogenesis in 3T3-L1 adipocytes and protects against high-fat diet-induced obesity and metabolic disorders in mice. (2019) Translational Research. 210:26-42 doi: 10.1016/j.trsl.2019.04.006
19. Wang TH, Chen CC (co-first), Hsiao YC, Lin YH, Pi WC, Huang PR, Wang TV, Chen CY. Heterogeneous Nuclear Ribonucleoproteins A1 and A2 Function in Telomerase-Dependent Maintenance of Telomeres. (2019) Cancers (Basel). 8;11(3) doi: 10.3390/cancers11030334
20. Chen CC, Chen CY, Wang SH, Yeh CT, Su SC, Ueng SH, Chuang WY, Hsueh C, Wang TH. Melatonin Sensitizes Hepatocellular Carcinoma Cells to Chemotherapy Through Long Non-Coding RNA RAD51-AS1-Mediated Suppression of DNA Repair. (2018) Cancers (Basel). 10;10(9) DOI: 10.3390/cancers10090320
21. Chen CC, Chen CY, Ueng SH, Hsueh C, Yeh CT, Ho JY, Chou LF, Wang TH. Corylin increases the sensitivity of hepatocellular carcinoma cells to chemotherapy through long noncoding RNA RAD51-AS1-mediated inhibition of DNA repair. (2018) Cell Death Dis. 1;9(5):543
22. Chen CC, Huang JS, Wang TH, Kuo CH, Wang CJ, Wang SH, Leu YL. Dihydrocoumarin, an HDAC Inhibitor, Increases DNA Damage Sensitivity by Inhibiting Rad52. (2017) Int J Mol Sci. 18(12),2655. doi: 10.3390/ijms18122655
23. Yeh CJ, Chen CC (co-first), Leu YL, Lin MW, Chiu MM, Wang SH. The effects of artocarpin on wound healing: in vitro and in vivo studies. (2017) Scientific reports; 7(1):15599. doi: 10.1038/s41598-017-15876-7
24. Chen CC, Liang CJ, Leu YL, Chen YL, Wang SH. Viscolin Inhibits In Vitro Smooth Muscle Cell Proliferation and Migration and Neointimal Hyperplasia In Vivo. (2016) PLoS one 11(12): e0168092. doi:10.1371/journal.pone.0168092
25. Chen CC, Lin MW, Liang CJ, Wang SH. The Anti-Inflammatory Effects and Mechanisms of Eupafolin in Lipopolysaccharide-Induced Inflammatory Responses in RAW264.7 Macrophages. (2016) PLoS One. 11(7):e0158662. doi: 10.1371/journal.pone.0158662
26. Wang SH, Lin PY, Chiu YC, Huang JS, Kuo YT, Wu JC, Chen CC*. Curcumin-Mediated HDAC Inhibition Suppresses the DNA Damage Response and Contributes to Increased DNA Damage Sensitivity. (2015) PLoS One. 10(7):e0134110. doi: 10.1371/journal.pone.0134110
27. Hu Z, Chen K, Xia Z, Chavez M, Pal S, Seol JH, Chen CC, Li W, Tyler JK. Nucleosome loss leads to global transcriptional up-regulation and genomic instability during yeast aging. (2014) Genes & Development, 15;28(4):396-408 DOI: 10.1101/gad.233221.113
28. Chen CC. & Tyler, J. K. Selective sensitization of cancer cells to DNA damage by a HAT inhibitor. (2009) Cell Cycle 8(18).
29. Chen CC. & Tyler, J. K. Chromatin assembly signals the end of repair. (2008) Cell Cycle, 7, 3792-7.
30. Chen CC., Carson, J., Feser, J., Tamburini, B., Zabaronick, S., Linger, J. & Tyler, J. K. Acetylation of lysine 56 on histone H3 drives chromatin assembly after repair and signals for the completion of double-strand DNA repair. (2008) Cell, 134, 231-43. OI: 10.1016/j.cell.2008.06.035
專利成果
本研究團隊已取得 6 項臺灣及美國發明專利，涵蓋健康老化、mTOR 與 SIRT1 調控、攝護腺肥大、發炎及組織纖維化等研究。已有學生因實質創意與技術貢獻，名列專利共同發明人；發明人資格依實際貢獻認定。
1.
專利類別：發明專利
專利名稱：(24S)-3β-羥基-5α-豆甾烷-6-酮於治療攝護腺肥大、發炎與組織纖維化之用途
專利國家：中華民國
專利號碼：I 932320
專利發明人：陳金銓、呂彥禮、陳琦媛、王東弘、鄭淑方
專利權人：長庚大學
專利類別：發明專利
專利名稱：用於延長壽命及／或延緩老化的方法
專利國家：中華民國
專利號碼：I 851326
專利發明人：陳金銓、呂彥禮、陳琦媛、王東弘、鄭淑方
專利權人：長庚大學
專利類別：發明專利
專利名稱：補骨脂寧和／或新補骨脂異黃酮於治療老化相關症狀的用途
專利國家：中華民國
專利號碼：I 832408
專利發明人：陳金銓、呂彥禮、王淑慧、王東弘、鄭淑方
專利權人：長庚大學
專利類別：發明專利
專利名稱：哺乳類TOR抑制劑
專利國家：美國
專利號碼：US 9,795,588 B2
專利發明人：陳金銓、王淑慧、呂彥禮
專利權人：長庚大學
專利類別：發明專利
專利名稱：哺乳類TOR抑制劑
專利國家：中華民國
專利號碼：I 586351
專利發明人：陳金銓、呂彥禮、王淑慧
專利權人：長庚大學
專利類別：發明專利
專利名稱：哺乳類SIRT1的活化劑
專利國家：中華民國
專利號碼：I 556818
專利發明人：陳金銓、呂彥禮、黃聰龍、方嘉佑、潘台龍
專利權人：長庚大學