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Progress Report Week 5
Last week, the team received the Dr.Pen microneedling device and opened it up this week to understand more about its working mechanism and then eventually the connection of the disposable system to the pen. In addition, the team 3D printed the prototype of the microneedle cartridge. This component contains several parts: the storage tank, exterior cover, spring, and pushing mechanism for the vertical movement. This goal of this prototype was to check whether different parts could be assembled together; further changes in dimension of the parts will be required.
Currently, the team worked on dimension and the attachment of the insulation layer (the insulation layer will made by medical silicon). Also, there will be an agent injection port on the storage tank and its characteristics will be determined this week.
In terms of the manufacturer, the team will contact the manufacturer once received information from the sponsors.
The team will focus on how to attach different components together to form the whole microneedling system (the storage tank, the insulation layer, the hollow needles, and the exterior layer).
3D printing the storage tank and adjust its dimensions
Goals for Next Week (list names after each item). Use specific and measurable objectives.
Finalize the design of the hollow needles attachment to the storage tank (detail circular pattern).
Manufacturing material of the storage rank will be decided.
Dimension of the silicone insulation layer.
Sponsor Comments from Last Meeting and Actions Taken to Address these Comments (indicate date of comments and if via email or in person)
Arranged weekly meeting to update and assist with the project.
Need to focus on hollow needles and agent delivery (no insulation)
Design and analyze of the insulation layer (will made from silicon)
Instructor Comments from Last Meeting and Actions Taken to Address these Comments (indicate date of comments and if via email or in person)
Primary focus was to explore top priorities; talk to the sponsor about it.
Force testing for hollow needles deformation point.
Silicon insulation layer.
Comments from Other Students in the Class (indicate date of comments and if via email or in person)
Risks and Areas of Concern
The structure or materials of the needles may deform/break during injection.
The needles arrangement across the device.
Leakage of agent from the device
Interference between hollow needles motion and agent motion
Attachment/assembly of the microneedling cartridge.
The electric insulation layer self-seal silicone.
Resources or Information Required but not Available
Contact information of the hollow microneedle manufacturer
The specific building material of the silicon insulation layer
Schedule
Budget (list amount spent and amount remaining)
$108 Dr.Pen device
$8.99 tattoo needles
$12.29 Syringes
$66.9 3D printing (not included if not exceed $100)
Money left = $3070.72
Progress on Report and Webpage
Report (finished by required sections as indicated)
Report view (please see the report document under Internal-->file)
Figure 1: Micro-needle system CAD design
Overview of Status of Analysis, Design, Fabrication, Tests, etc.
Experimental Setup: the storage tank will be connected with the syringe. Used water as a testing liquid because it has a similar characteristic compared to plasma. Then force will be applied to push the syringe (the weight will be measured and recorded), then the mass flow rate will be recorded and documented.
Setup experiments on testing the behaviors of the needles. The characteristics that the team focuses on, but not limited to, are the depth of the microneddle’s penetration through different objects such as pig-skin or jelly, or something that is similar to the stiffness of the human skin (this test will be scheduled in week 5);
Accomplishments from Previous Week
3D printed the prototype
Contact sponsors for the manufacturer information
Micro-needles buckling and deformation force testings
Result of the force testing: https://docs.google.com/spreadsheets/d/1PAaeHrKXAhYLiRmO2i6NJRCRf595pJIREfSl0BGpKg4/edit?usp=sharing
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