2021 - Multiaversive

The proposed neural architecture of multimodal negative affect. Anatomical ROIs were selected a priori (Supplementary Table 7), with the exception of the mechanical pain-selective S1 ROI, which was localized in the current study (Fig. 3). Plots show structure coefficients for each model. Structure coefficients were averaged across voxels within ROI tested for significance for each model and across participants (N= 55); one-sample t-test treating subject as random effect; *P< 0.05; **P< 0.01; ***P< 0.001 (for exact P values and the associated t-statistics, see Supplementary Table 10); t-tests were performed on all data (positive and negative), but only P values associated with positive t-values are marked and interpreted; each dot is a participant, bars reflect group means and error bars reflect within-participant s.e.m. The upper-right inset shows co-localization of processing in the insula, cingulate, somatosensory cortex and thalamus. The lines display selected major anatomical projections based on previous literature. Individual OFC and MPFC regions, MCC subregions, V1–V4 visual cortex and A1–A3 auditory cortex showed similar profiles thus were combined here. Thalamic nuclei: Pulv, pulvinar; Audi, A1–A3, primary and intermediate auditory cortices; Visual, V1/V2/V3/V4, primary and intermediate visual cortex; Audi INS, ventroposterior (auditory) insula (area 52, retroinsular cortex).