2017 - Pain

Multivariate fMRI signature that is predictive of variations in pain after controlling for stimulus intensity and NPS response (SIIPS1).

The multivariate pattern of fMRI activity predictive of residual pain ratings after removing the effects of the stimulus intensity and NPS response, termed the stimulus intensity independent pain signature-1 (SIIPS1). The map shows thresholded voxel weights (at qo0.05 false discovery rate (FDR), equivalent to uncorrected voxel-wise Po0.0025) based on weighted t-tests across maps for 137 subjects in the training data sets (Studies 1–4). Thresholding was performed for display only; all weights were used in the subsequent analyses. Some examples of unthresholded patterns are presented in the insets; small squares indicate individual voxel weight. aINS, anterior insula; CB, cerebellum; dmPFC, dorsomedial PFC; dpINS, dorsal posterior insula; HC, hippocampus; MCC, mid-cingulate cortex; midINS, middle insula; NAc, nucleus accumbens; SMA, supplementary motor area; TP, temporal pole; vmPFC, ventromedial PFC; vlPFC, ventrolateral PFC.