2018 - Pain - Cognitive control - Negative Emotion
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Reference
Kragel, P.A., Kano, M., Van Oudenhove, L., Ly, H.G., Dupont, P., Rubio, A., Delon-Martin, C., Bonaz, B.L., Manuck, S.B., Gianaros, P.J., Ceko, M. Reynolds Losin, E.A., Woo, C.W., Nichols, T.E., Wager, T.D. (2018). Generalizable representations of pain, cognitive control, and negative emotion in medial frontal cortex. Nature neuroscience, 21(2):283-289. PMCID: PMC5801068.
Representational mapping of pain, cognitive control, and negative emotion in MFC.
Searchlight maps display where local patterns of brain activity are consistent with domain-specific representation of pain (red), cognitive control (green), and negative emotion (blue; n= 270 participants). b, Additive conjunction of searchlight maps, with each domain mapped onto orthogonal dimensions in the red–green–blue (RGB) color space. Overlap between pain and cognitive control is depicted in yellow; overlap between pain and negative emotion is colored magenta. Maps are thresholded at P< 0.05, two-tailed, uncorrected cutoff to highlight any possible overlap (n= 270 participants). c, Brain maps of Bayes factors indicating relative evidence against overlap among the three domains at each voxel. Smaller values indicate evidence against overlap; values less than 0.1 are considered strong evidence (n= 270 participants). d, River plots depict the similarity between searchlight maps and anatomical parcellation of MFC (left) and functional parcellation of cortical regions from resting-state data48 (right). Line thickness indicates the degree of correspondence between sets. vAttention, ventral attention; dAttention, dorsal attention. Images are displayed using radiological convention.