Embedded Files
This project will study the types of neural responses present in the cortico-basal ganglia-thalamic circuit when producing a sequence of syllables. We will examine ECoG recordings and DBS recordings from the STN, GPi, and VIM thalamic nucleus for responses predicted by the GODIVA model and from primate studies of motor sequencing (such as Shima and Tanji 2000). Particulator attention will be paid to possible ways that speech sequence planned are maintained prior to production of those elements, including the possibility of Competitive Queueing mechanisms as described in Bohland et al. 2010 and Averbeck et al. 2002. Analyses will be conducted in collaboration with members of the lab of Mark Richardson at Mass General Hospital. Raw data was originally collected by Mark Richardson and colleagues at the University of Pittsburgh Medical Center with funding from the 2016-2019 NIH U01 grant titled "Subthalamic and cortico-subthalamic coding of speech production" (grant ID: U01 NS098969). All study documents can be found on the shared drive here.
This project will study the types of neural responses present in the cortico-basal ganglia-thalamic circuit when producing a sequence of syllables. We will examine ECoG recordings and DBS recordings from the STN, GPi, and VIM thalamic nucleus for responses predicted by the GODIVA model and from primate studies of motor sequencing (such as Shima and Tanji 2000). Particulator attention will be paid to possible ways that speech sequence planned are maintained prior to production of those elements, including the possibility of Competitive Queueing mechanisms as described in Bohland et al. 2010 and Averbeck et al. 2002. Analyses will be conducted in collaboration with members of the lab of Mark Richardson at Mass General Hospital. Raw data was originally collected by Mark Richardson and colleagues at the University of Pittsburgh Medical Center with funding from the 2016-2019 NIH U01 grant titled "Subthalamic and cortico-subthalamic coding of speech production" (grant ID: U01 NS098969). All study documents can be found on the shared drive here.
Server Addresses
Server Addresses
When on the Richardson Lab server, uses the following addresses to access experimental data:
BMLNAS - 132.183.240.28 – Nexus, Nexus2, and Nexus3 - Pitt (2,3,5 clinical epilepsy)... map Nexus to Z drive; this is where Pitt Triplet data is stored
BMLNAS2 - 132.183.240.49 - Nexus4 and Nexus5 - MGH RNS databank... map Nexus4 to Y drive; this is where MGH DBS-SEQ data is stored
BMLNAS3 - 132.183.240.51 - Epsilon - MGH Clinical epilepsy databank
-to map network drives after logging into securelink, open windows explorer, right click on Network, select ‘Map network drive’, then enter:
\\132.183.240.49\Nexus4 ………………..Map to Y drive; this is where MGH DBS-SEQ and STOP trial data is stored
\\132.183.240.28\Nexus ……………… map to Z drive; this is where Pitt Triplet data is stored
-can also map these network drives to local machine via ethernet within the Richardson lab; login and password are the same as for SecureLink
Protocols
Protocols
Link to all study protocols, e.g., technical documentation for how to set up equipment, calibrate sound, run scripts, QA data
Literature
Literature
Early description of types of cortical neural responses during sequential movement:
Shima and Tanji 2000: Neuronal Activity in the Supplementary and Presupplementary Motor Areas for Temporal Organization of Multiple Movements
GODIVA Model:
Bohland et al. 2010: Neural representations and mechanisms for the performance of simple speech sequences
Evidence for competitive queuing in nonspeech tasks:
Averbeck et al. 2002 - macaque, single unit, tracing task
Kornysheva et al. 2019 - human, MEG, finger pressing
First publication of task and recording protocols:
Bush et al. 2022: Differentiation of speech-induced artifacts from physiological high gamma activity in intracranial recordings
Frank's list of Shima/Tanji papers on macaque motor sequencing neurophysiology
Presentations
Presentations
Link to internal presentations (e.g., lab meetings/results updates)
Link to external presentations (e.g., conference, external talks)
Manuscripts
Manuscripts
Link to manuscripts in collaborative software (e.g., google drive, one drive)
Link to PDFs at key points in publication process (e.g., preprints, final accepted version, published version)
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