This is a central location for the lab's publication citations, conference presentations, posters, book chapters, etc.  As soon as you have a publication citation of any kind (preprint, postprint, published), please update this document. Bobbie compiles annual NIH reports for each grant, annual BU reports for each protocol, updates the BU lab website, as well as various faculty and staff reports that require lab output updates. This central location will reduce the number of emails you get from her when reports are due as well as maintain a comprehensive list of the lab's hard work.

Short description of study, funding, PIs. Link to shared drive.

The Autism Centers of Excellence (ACE) Program Morphometry project investigates the brains of children and adolescents with Autism Spectrum Disorder (ASD) using fMRI. This project specifically focuses on local gyrification index (LGI) to examine cortical gyrification. LGI is a ratio of the amount of visible cortex to the amount of cortex in the sulcal folds in regions of interest (ROIs) on a 3D reconstruction of the cortical surface. Relevant study documents can be found on the shared drive. The data was collected by Liz Heller-Murray.

Lab-wide administrative information and documents.

Link to shared drive here.

The Articulator Activation Likelihood Estimation (ArticALE) study is a meta-analysis of brain activation associated with simple, non-speech movements of the articulators. It is funded by the DIVA grant (RO1 DC002852, PI: F. Guenther). All study documents can be found on the shared drive here. The Slack channel is here.

Auditory Development (AudDev) is an umbrella project for various pilot studies where we are testing different variations of auditory perturbation paradigms. These paradigms are run in the sound-booth in the lab.

Link to the shared drive here. Slack channel here.

This project will further investigate the neurophysiological mechanisms of speech motor sequence learning explored in Segawa et al. 2015. The aim of this project is to understand how  learning to produce novel non-native pseudowords changes responses in the cortico-basal ganglia-thalamic loop during speech production. Simultaneous single-unit recordings in the subthalamic nucleus and electrocorticography recordings will be performed in Parkinson's patients undergoing surgery for implantation of deep-brain stimulation (DBS) electrodes. Experiments will be conducted in collaboration with the lab of Mark Richardson at Mass General Hospital. This study will be funded by U01 grant entitled ""Basal ganglia-cortical networks for speech production" (PI: F. Guenther, R.M. Richardson).  All study documents can be found on the shared drive here. The Slack channel for this project is here. There is also an MGH Slack channel for the project here.

This project will study the types of neural responses present in the cortico-basal ganglia-thalamic circuit when producing a sequence of syllables. We will examine ECoG recordings and DBS recordings from the STN, GPi, and VIM thalamic nucleus for responses predicted by the GODIVA model and from primate studies of motor sequencing (such as Shima and Tanji 2000). Analyses will be conducted in collaboration with members of the lab of Mark Richardson at Mass General Hospital. Raw data was originally collected by Mark Richardson and colleagues at the University of Pittsburgh Medical Center with funding from the 2016-2019 NIH U01 grant titled "Subthalamic and corticosubthalamic coding of speech production" (grant ID: U01 NS098969). All study documents can be found on the shared drive here. 

The Simulink DIVA model represents an implementation of the DIVA model in Matlab’s Simulink environment. The model is composed of several modules (Simulink subsystems), representing different brain areas involved in speech production. All study documents can be found on the shared drive here.  The Slack channel for this project is here.

The Following project examines the distribution of responses to auditory perturbations and seeks to find evidence (or a lack thereof) of the frequently reported following responses. It is funded by the DIVA grant (RO1 DC002852, PI: F. Guenther). All study documents can be found on the shared drive here. The Slack channel for this project is here.

Short description of study, funding, PIs. Link to shared drive.

The stuttering pooled morphometry (PWSMorph) study involves analysis of morphometric brain measures pooled across previous AWS studies (STUT, SEQPDS, and RHY) as well as CWS studies from data collected by S. Chang. Work funded by R01 DC007683 and R01 DC007683 (PI: F. Guenther). All study documents can be found on the shared drive here. The Slack channel for BU-specific aspects of this project is here. The Slack channel for aspects having to do with the Chang lab are here.

Short description of study, funding, PIs. Link to shared drive.

The Somatosensory and Auditory Perturbation (SAP) study refers to the neural component of the work proposed in the PD grant (R01 DC016270; awarded 2018-2023 to F. Guenther and C. Stepp). The primary aim of this work is to determine the relative contributions of feedforward and feedback control systems to the speech disorder in Parkinson’s disease (PD). The grant proposed examining neural responses to reflexive perturbations in auditory and somatosensory domains and relating those findings to functional speech outcomes, such as speech intelligibility. All study documents can be found on the shared drive here. The Slack channel for this project is here.

The SEQ-FTD study will be a replication of the non-native cluster learning studies (SEQMP and SEQWM) in patients diagnosed with frontotemporal disorders (including primary progressive aphasia). The project aims to determine regions of the brain in which cortical thickness in FTD patients is associated with learning of non-native clusters. Pilot data for this project will be funded by the SEQ grant (R01 DC007683 , PI: F. Guenther) and will be included in an F31 proposal (PI: H. Miller). All study documents can be found on the shared drive here. The Slack channel for this project is here.

The purpose of this fMRI study is to investigate the neural mechanisms involved in speech sequencing in people who stutter (PWS) and people with no stuttering (PNS). The first part of the study includes adults with stuttering (AWS) and adults with no stuttering (ANS). The second part of the study (in collaboration with Chang Lab at the University of Michigan) includes children with persistent developmental stuttering (CWS) and children with no stuttering (CNS). 

The purpose of this study is to test the idea that auditory feedback is used more than somatosensory feedback during learning of new speech motor patterns. Auditory perturbations will be applied to subjects while they speak syllables with native consonant clusters, learned nonnative clusters, and novel nonnative clusters (as in Segawa et al. 2015). The hypothesis to test is that auditory perturbations will have a greater effect when producing novel nonnative consonant clusters than learned nonnative clusters (and even greater relative to natives), because the somatosensory feedback system is not as active and therefore does not counteract auditory feedback control as much as with learned speech motor patterns. 

Project shared drive ........ project web page

Short description of study, funding, PIs. Link to shared drive.

The SimpleDIVA study involves the development and testing of simplified versions of DIVA for examining acoustic responses to auditory perturbation paradigms. This work was funded by the DIVA grant (R01 DC002852, PI: F. Guenther). All study documents can be found on the shared drive here.  The Slack channel for this project is here.

The Speaking Rate (SRATE) study investigates the behavioral and neural correlates of changing speaking style (i.e., normal, emphatic, clear, fast) during sentence production. It is funded by the DIVA grant (R01 DC002852, PI: F. Guenther). All study documents can be found on the shared drive here.  The Slack channel for this study is here.

The Stuttering Taxometrics project aims to test whether stuttering in adults and children is dimensional (i.e. a "spectrum") or categorical. This project aims to collaborate with researchers who have collected datasets of stuttering-related metrics, such as stuttering frequency and dysfluency durations, from a large enough population of stutterers and non-stutterers (n=300 subjects) to use taxometric procedures. Techniques will be employed from the field of taxometrics, which is a suite of tools traditionally employed in psychiatry for testing whether pathology constructs (in this case stuttering) describe disreet categories or instead a continuum of severity levels 

This project, funded by the sequencing grant, investigates the behavioral responses to timing perturbations in CWS (in collaboration with the Chang lab), AWS, and matched controls.  All study documents can be found on the shared drive here. The slack channel for this project is here.

The Choice Reaction Time (CRT) project aims to determine the nature of syllable sub-units in phonological working memory. The project compares reaction times for different syllable structures (CV, CCV, CVC, VC, VCC) in a choice reaction time paradigm in order to determine if sub-units in phonological working memory are a single phoneme, consonant cluster, or onset-coda structure. Project is funded by the sequencing grant (R01 DC007683, PI: F. Guenther). All study documents can be found on the shared drive here.  The Slack channel for this project is here.

The Dissociating Roles of Feedback in Voice Motor Control (DRF) study investigated the role of somatosensory and auditory feedback control in voice production. This work was funded by the following NIDCD grants: R01 DC002852, PI: F. Guenther; R01 DC016270, PIs: C. Stepp, F. Guenther; R01 DC015570, PI: C. Stepp. All study documents can be found on the shared drive here. There is no Slack channel for this completed project.

The ECoG Response Clustering (ECoG-Clust) project investigates a timecourse-based typology of neural responses during speech production by performing clustering on intrasurgical electrocortigraphy (ECoG) responses. This study focuses on ECoG high gamma power responses within the frontal, somatomotor, and temporal cortices of patients with epilepsy while they vocalized syllable pairs. Machine learning methods are employed to find temporally clustered ECoG sites, followed by classification analyses to determine how each cluster represents stimulus information within its responses.  Current work on this project is funded by U01 grant entitled ""Basal ganglia-cortical networks for speech production" (PI: F. Guenther, R.M. Richardson). All study documents can be found on the shared drive here. Please use our slack channel for communications, greenlee-ecog-collaboration.

The Primary Progressive Aphasia- Working Memory (PPA-WM) study involves analysis of the relationship between atrophy in PPA patients at the MGH-Frontotemporal Disorders Unit and performance on phonological working memory tasks. The primary aim of this work is to test the involvement of left pIFS in PWM tasks, as proposed by GODIVA. (Work funded by R01 DC007683 and R01 DC002852 (PI: F. Guenther), R01 DC014296 (PI: B. Dickerson). All study documents can be found on the shared drive here. The Slack channel for this project is here.

This RHY project covers two separate but related studies aimed at understanding 1) the neural processing of the “rhythm effect” in stuttering as well as 2) the effect of metronome-timed speech on auditory feedback perturbations.  This project has been funded through the SEQ grant (R01DC007683, PI: Frank Guenther). All study documents can be found on the shared drive here.  There is no Slack page for this completed study.

This study, funded under the sequencing grant, investigated the neural bases of learning of novel syllables composed using non-native consonant clusters in AWS and matched controls. All study documents can be found on the shared drive here.  There is no Slack channel for this completed study.