Embedded Files
Project Description
Project Description
This project investigates the neurophysiological mechanisms of speech motor sequence learning explored in Segawa et al. 2015. The aim of this project is to understand how learning to produce novel non-native pseudowords changes responses in the cortico-basal ganglia-thalamic loop during speech production. Simultaneous local field potential (LFP) recordings in the external globus pallidus (GPe), ventral intermediate thalamus (VIM), and subthalamic nucleus (STN) are performed at the same time as electrocorticography recordings. Data is collected from Parkinson's patients undergoing surgery for implantation of deep-brain stimulation (DBS) electrodes. Experiments are conducted in collaboration with the lab of Mark Richardson at Mass General Hospital. This study is funded by U01 grant entitled "Basal ganglia-cortical networks for speech production" (PI: F. Guenther, R.M. Richardson).
Analysis of this project data is divided into two arms:
1. GO trials: analysis of responses difference (magnitude across areas, speech encoding, functional connectivity) in native vs. nonnative (trained and novel) syllables
-scientific focus is on speech sequence learning
-primary neural response = broadband high gamma
-project lead = Andrew Meier
2. STOP trials: analysis of response differences in STOP vs. GO trials and successful vs. unsuccessful stop responses
-scientific focus is on motor inhibition in the context of speech production
-primary neural response = beta bursts
-project lead = Rohan Deshpande
Note: Richardson Lab materials (documents, data, code) refer to this task as "Speech Motor Sequence Learning" (SMSL) instead of "DBS-SEQ."
Server Addresses
Server Addresses
When on the Richardson Lab server, uses the following addresses to access experimental data:
BMLNAS - 132.183.240.28 – Nexus, Nexus2, and Nexus3 - Pitt (2,3,5 clinical epilepsy)... map Nexus to Z drive; this is where Pitt Triplet data is stored
BMLNAS2 - 132.183.240.49 - Nexus4 and Nexus5 - MGH RNS databank... map Nexus4 to Y drive; this is where MGH DBS-SEQ data is stored
BMLNAS3 - 132.183.240.51 - Epsilon - MGH Clinical epilepsy databank
-to map network drives after logging into securelink, open windows explorer, right click on Network, select ‘Map network drive’, then enter:
\\132.183.240.49\Nexus4 ………………..Map to Y drive; this is where MGH DBS-SEQ and STOP trial data is stored
\\132.183.240.28\Nexus ……………… map to Z drive; this is where Pitt Triplet data is stored
-can also map these network drives to local machine via ethernet within the Richardson lab; login and password are the same as for SecureLink
Protocols
Protocols
Literature
Literature
Richardson Lab publications (ECoG with DBS):
Chrabaszcz et al. 2019: Subthalamic Nucleus and Sensorimotor Cortex Activity During Speech Production
https://www.jneurosci.org/content/39/14/2698
Lipski et al. 2018: Subthalamic Nucleus Neurons Differentially Encode Early and Late Aspects of Speech Production
https://www.jneurosci.org/content/38/24/5620
Lipski et al. 2017: Dynamics of human subthalamic neuron phase-locking to motor and sensory cortical oscillations during movement
https://journals.physiology.org/doi/full/10.1152/jn.00964.2016
Fischer et al. 2018: Cortico-basal-ganglia communication: Temporally structured activity for selective motor control
https://www.biorxiv.org/content/10.1101/413286v1.full
Alhourani et al. 2020: Subthalamic Nucleus Activity Influences Sensory and Motor Cortex during Force Transduction
https://academic.oup.com/cercor/article/30/4/2615/5669892
Motor learning task papers
Segawa et al. 2015: The Neural Correlates of Speech Motor Sequence Learning
Segawa et al. 2019: Chunking of phonological units in speech sequencing
Masapollo, Segawa, ea 2021: Behavioral and neural correlates of speech motor sequence learning in stuttering and neurotypical speakers: an fMRI investigation
Masapollo, Smith, Guenther 2019: Dissociation between phonological working memory structures and motor programming units during speech motor-sequence learning
Chanoin ea 2025 - meg - Dataset for Evaluating the Production of Phonotactically Legal and Illegal Pseudowords
garzon ea 2023 - fmri, finger press seq - learning reduces task activation in secondary and not primary sensorimotor areas
ebrahimi and ostry 2024 - reach task w/ rotational perturbation - S1 and not M1 (disruptive) theta stim following learning of perturbation inhibits retention of learning
todorovic ea 2024 - fmri - french speakers producing nonnative CCVCC [from Serbian] - no training phase, produced each syl 25x
STOP task papers:
Alegre ea 2013 - dbs in stn - responses during stop task
Pasquereau and Turner 2017 - monkey 1 unit - STN neurons in ventromedial region code for stopping on cue
Swann et al. 2009 - ecog, stop task - greater beta response in m1 and ifg on successful than unsuccessful stops
London ea 2020 - dbs - stn activity decreases when subject needs to switch target mid task (reaching task)
khan ea 2024 - intrasurgical DBS + ecog strips - Low-Frequency Oscillations in Mid-rostral Dorsolateral Prefrontal Cortex Support Response Inhibition
bowersock ea 2025 - Theta and beta power in the subthalamic nucleus responds to conflict across subregions and hemispheres
wessel ea 2022 - hand emg, stop task, tms - dbs disruption of stn or successful stopping inhibits hand (ie global) excitability
Willett ea 2024 - dorsal vs ventral stn stim - stimulus-action-outcome task
-stop vs. go task, button press
-dorsal vs. ventral within-subjects, order counterbalanced… no dbs-off condition
Lofredi ea 2021 - Subthalamic stimulation impairs stopping of ongoing movements
Soh ea 2024 - The human subthalamic nucleus transiently inhibits active attentional processes
obeso ea 2024 - The causal role of the subthalamic nucleus in the inhibitory network
STN + ECoG STOP task papers
Zhao ea 2023 - ''Inhibitory control of speech production in the human premotor frontal cortex'
-very similar to our STOP task, but doesn't include subcortical recordings
Diesburg et al. 2021 [Greenlee lab] - Cortico-subcortical β burst dynamics underlying movement cancellation in humans
Chen et al. 2020 - Prefrontal-Subthalamic Hyperdirect Pathway Modulates Movement Inhibition in Humans
Wessel et al. 2019 [Greenlee lab]- Non-selective inhibition of inappropriate motor-tendencies during response-conflict by a fronto-subthalamic mechanism
Mosher et al. 2021 Distinct roles of dorsal and ventral subthalamic neurons in action selection and cancellation
choi ea 2025 - ecog+dbs LFP - erikson flanker task
Motor inhibition
isabella ea 2021 - MEG, go/switch task - Inhibitory Control in the Absence of Awareness: Interactions Between Frontal and Motor Cortex Oscillations Mediate Implicitly Learned Responses
isabella ea 2015 - MEG, go/switch task - Complementary roles of cortical oscillations in automatic and controlled processing during rapid serial tasks
Lab Presentations
Lab Presentations
External Presentations
Manuscripts
Manuscripts
Link to PDFs at key points in publication process (e.g., preprints, final accepted version, published version)
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