Mesopotamia is located in the southwestern Asia or modern day Iraq. The name comes is Greek for "Between Rivers" and the name refers to the Tigris River and the Euphrates River. This area is also referred to as "The Fertile Crescent" and "The Cradle of Civillation.  Mesopotamia benefited from the regions climate and geographic features, which helped the early human civilizations. This area culture influenced and spread throughout the Middle East, the Indus River Valley, Egypt, and the Mediterranean. 

Check out the video on the right to lean more about Mesopotamia's Location, and more specifically how Mesopotamia became the birthplace for humanity's first city's, developments in both math and science, and the first evidence of literacy and a legal system.  Also check out This websites video to lean more on Mesopotamia's location, trade routes, and impact.