Student News
Recent Graduate Student Publications
*Graduate student authors are underlined.
2024
Adolescent ethanol exposure promotes mechanical allodynia and alters dopamine transmission in the nucleus accumbens shell.
Kelley AM, Del Valle EJ, Zaman S, Karkhanis AN. Pain. 2024; 165(6): e55-e64.
https://pubmed.ncbi.nlm.nih.gov/37962155/
Characterization of striatal dopamine dynamics in the pre-formed fibril rat model of Parkinson's disease. Centner, A., Del Priore, I., Chambers, N., Cohen, S., Terry, M., Coyle, M., Glinski, J., Sortwell, C., Bishop, C. European Journal of Neuroscience (2024) Apr;59(7):1585-1603. (PMID:38356120).
The effects of L-DOPA on gait abnormalities in a unilateral 6-OHDA rat model of Parkinson's disease. Holden, H., Venkatesh, S., Budrow, C., Nezaria, S., Coyle, M., Centner, A., Lipari, N., McManus, G., Bishop, C. (2024). Physiol Behav. 8:281:114563. (PMID:38723388).
Adolescent alcohol and the spectrum of cognitive dysfunction in aging. Deak T, Burzynski HE, Nunes PT, Day SM, Savage LM. In: Effects of Alcohol on the Brain across the Lifespan - Recent Advances from Preclinical Studies.(2024) Eds: Valenzuela CF, Linsenbardt D, Weiner J. Springer, New York.
Modulation of the p75NTR during adolescent alcohol exposure prevents cholinergic neuronal atrophy and associated acetylcholine activity and behavioral dysfunction. Kipp BT*, Savage, LM. (2024). International Journal of Molecular Science, 24, 5792. http://doi.org/10.3390/ijms25115792.
2023
Modes of Acetylcholine Signaling in the Prefrontal Cortex: Implications for Cholinergic Dysfunction and Disorders. Fecik MJ & Savage LM.In (Ed T. Heinbockel). Acetylcholine - Recent Advances and New Perspectives. (2023) 10.5772/IntechOpen. 110462 Rijeka, Croatia.
A critical review of effects of ethanol intake of the dynorphin/kappa opioid receptor system in the extended amygdala: From inhibition to stimulation.
Pirino BE, Kelley AM, Karkhanis AN, Barson JR Alcohol Clin Exp Res (Hoboken). 2023; 47(6): 1027-1038.
https://pubmed.ncbi.nlm.nih.gov/37042026/
Adult-born neurons maintain hippocampal cholinergic inputs and support working memory during aging. Dranovsky A, Kirshenbaum G, Chang CY, Bompolaki M, Bradford V, Bell J, Kosmidis S, Shanksy R, Orlandi J, Savage LM, Leonardo E, Harris A. Molecular Psychiatry, (2023). doi: 10.1038/s41380-023-02167.
Prefrontal cortex glutamatergic adaptations in a mouse model of alcohol use disorder.
Siddiqi MT, Podder D, Pahng AR, Athanason AC, Nadav T, Cates-Gatto C, Kreifeldt M, Contet C, Roberts AJ, Edwards S, Roberto M, Varodayan FP.
Addict Neurosci. 2023 Dec 15;9:100137.
https://pubmed.ncbi.nlm.nih.gov/38152067/
Chronic ethanol alters adrenergic receptor gene expression and produces cognitive deficits in male mice.
Athanason AC, Nadav T, Cates-Gatto C, Roberts AJ, Roberto M, Varodayan FP.
Neurobiol Stress. 2023;24:100542.
Determining the neuronal ensembles underlying sex-specific social impairments following adolescent intermittent ethanol exposure.
Towner TT, Goyden MA, Coleman HJ, Drumm MK, Ritchie IP, Lieb KR, Varlinskaya EI, Werner DF.
Neuropharmacology. 2023; 238: 109663.
Striatal serotonin transporter gain-of-function in L-Dopa-treated, hemi-parkinsonian rats.
Conti Mazza MM, Centner A, Werner DF, Bishop C.
Brain Res. 2023; 1811;148381.
Budrow C, Elder K, Coyle M, Centner A, Lipari N, Cohen S, Glinski J, Kinzonzi N, Wheelis E, McManus G, Manfredsson F, Bishop C.
Cells. 2023 Mar 8;12(6):837. doi: 10.3390/cells12060837.
Lipari N, Centner A, Glinski J, Cohen S, Manfredsson FP, Bishop C.
Neurobiol Dis. 2023 Jan;176:105965. doi: 10.1016/j.nbd.2022.105965. Epub 2022 Dec 13.
Lipari N, Centner A, Glinski J, Cohen S, Manfredsson FP, Bishop C.
Neurobiol Dis. 2023 Jan;176:105965. doi: 10.1016/j.nbd.2022.105965. Epub 2022 Dec 13.
Repeated dosing with cocaine produces strain-dependent effects on responding for conditioned reinforcement in Collaborative Cross mice.
Marsland, P., Trapp, S., Vore, A.S., Lutzke, A., Varlinskaya, E.I. & Deak, T.
Cells, in press. (2023)
Intermittent exposure to a single bottle with ethanol modulates stress sensitivity: Impact of age at exposure initiation.
Bailey LS, Bagley JR, Wherry JD, Chesler EJ, Karkhanis A, Jentsch JD, Tarantino LM.
Psychopharmacology (Berl). 2023 Mar;240(3):561-573.
Cues associated with repeated ethanol exposure produce a conditioned corticosterone response in adult male Sprague Dawley rats: implications for
neuroimmune regulation.
Mondello, J.E., Gano, A., Vore, A.S., & Deak, T. (2023).
American Journal of Drug and Alcohol Abuse, 2023, 1-11. doi: 10.1080/00952990.2023.2169831.
https://pubmed.ncbi.nlm.nih.gov/36862971/
Sex-specific effects of ethanol consumption in older Fischer 344 rats on microglial dynamics and Ab(1-42) accumulation.
Marsland, P., Vore, A.S., DaPrano, E., Paluch, J.M., Blackwell, A.A., Varlinskaya, E.I., & Deak, T.
Alcohol, 2023, 107, 108-118. doi: 10.1016/j.alcohol.2022.08.013.
https://pubmed.ncbi.nlm.nih.gov/36155778/
Prenatal methadone exposure leads to disruptions in adult-born dentate granule cell survival and female persistent fear responding
Gamble ME & Diaz MR
Addiction Neuroscience. 2023 https://doi.org/10.1016/j.addicn.2023.100120.
2022
KOR Control over Addiction Processing: An Exploration of the Mesolimbic Dopamine Pathway.
Estave PM, Spodnick MB, Karkhanis AN
Handb Exp Pharmacol. 2022;271:351-377.
Alcohol, inflammation, and blood-brain barrier function in health and disease across development.
Vore AS, Deak T.
Int Rev Neurobiol. 2022;161:209-249.
Prenatal methadone exposure leads to long-term memory impairments and disruptions of dentate granule cell function in a sex-dependent manner.
Gamble ME, Marfatia R, Diaz MR.
Addict Biol. 2022 Sep;27(5):e13215.
The effects of Vilazodone, YL-0919 and Vortioxetine in hemiparkinsonian rats.
Smith S, Sergio J, Coyle M, Elder K, Centner A, Cohen S, Terry M, Lipari N, Glinski J, Wheelis E, Budrow C, Bishop C.
Psychopharmacology (Berl). 2022 Jul;239(7):2119-2132.
The multimodal serotonin compound Vilazodone alone, but not combined with the glutamate antagonist Amantadine, reduces l-DOPA-induced dyskinesia in hemiparkinsonian rats.
Cohen SR, Terry ML, Coyle M, Wheelis E, Centner A, Smith S, Glinski J, Lipari N, Budrow C, Manfredsson FP, Bishop C.
Pharmacol Biochem Behav. 2022 Jun;217:173393.
Circulating corticosterone levels mediate the relationship between acute ethanol intoxication and markers of NF–kB activation in male rats.
Barney TM, Vore AS, Trapp SL, Finkenberg CL, Pugliesi DR, Schmalzle MM, Evans SH, Varlinskaya EI, Deak T.
Neuropharmacology. 2022 Jun 1;210:109044.
Impact of adolescent intermittent ethanol exposure in male and female rats on social drinking and neuropeptide gene expression.
Towner TT, Papastrat KM, Spear LP, Varlinskaya EI, Werner DF.
Alcohol Clin Exp Res. 2022 Jun;46(6):979-993.
Modulation of nigral dopamine signaling mitigates parkinsonian signs of aging: evidence from intervention with calorie restriction or inhibition of dopamine uptake.
Salvatore MF, Kasanga EA, Kelley DP, Venable KE, McInnis TR, Cantu MA, Terrebonne J, Lanza K, Meadows SM, Centner A, Bishop C, Ingram DK.
Geroscience. 2022 May 30. doi: 10.1007/s11357-022-00583-7. Online ahead of print.
Neuroendocrine and neuroimmune responses in male and female rats: evidence for functional immaturity of the neuroimmune system during early adolescence.
Marsland P, Parrella A, Orlofsky M, Lovelock DF, Vore AS, Varlinskaya EI, Deak T.
Eur J Neuroscience. 2022 May;55(9-10):2311-2325.
Prenatal and adolescent alcohol exposure programs immunity across the lifespan: CNS-mediated regulation.
Deak T, Kelliher KT, Wojcik HJ, Gano A.
Pharmacol Biochem Behav. 2022 May; 216:173390.
Adolescent intermittent ethanol exposure produces sex-specific changes in BBB Permeability: A potential role for VEGFA.
Vore AS, Barney TM, Deak MM, Varlinskaya EI, Deak T.
Brain Behav Immun. 2022 May;102:209-223.
https://pubmed.ncbi.nlm.nih.gov/35245677/
Moderate prenatal alcohol exposure modifies sex-specific CRFR1 activity in the central amygdala and anxiety-like behavior in adolescent offspring.
Rouzer SK, Diaz MR.
Neuropsychopharmacology. 2022 Apr 27. Online ahead of print.
Impact of Adolescent Intermittent Ethanol Exposure on Social Investigation, Social Preference, and Neuronal Activation in cFos-LacZ Male and Female Rats.
Towner TT, Applegate DT, Varlinskaya EI, Werner DF.
Front Pharmacol. 2022 Mar 23;13:841657.
Behavioral phenotypes revealed during reversal learning are linked with novel genetic loci in diversity outbred mice.
Bagley JR, Bailey LS, Gagnon LH, He H, Philip VM, Reinholdt LG, Tarantino LM, Chesler EJ, Jentsch JD.
Addict Neurosci. 2022 Dec;4:100045.
2021
Heritable variation in locomotion, reward sensitivity and impulsive behaviors in a genetically diverse inbred mouse panel.
Bailey LS, Bagley JR, Dodd R, Olson A, Bolduc M, Philip VM, Reinholdt LG, Sukoff Rizzo SJ, Tarantino L, Gagnon L, Chesler EJ, Jentsch JD.
Genes Brain Behav. 2021 Nov;20(8):e12773.
Adolescent Binge-Type Ethanol Exposure in Rats Mirrors Age-Related Cognitive Decline by Suppressing Cholinergic Tone and Hippocampal Neurogenesis.
Reitz NL, Nunes PT, Savage LM.
Front Behav Neurosci. 2021 Oct 22;15:772857.
Patterned Feeding of a Hyper-Palatable Food (Oreo Cookies) Reduces Alcohol Drinking in Rats.
Leon Z, Shah K, Bailey LS, Karkhanis AN, Sirohi S.
Front Behav Neurosci. 2021 Oct 20;15:725856.
Adolescent Ethanol Exposure Alters Cholinergic Function and Apical Dendritic Branching Within the Orbital Frontal Cortex.
Kipp BT, Nunes PT, Galaj E, Hitchcock B, Nasra T, Poynor KR, Heide SK, Reitz NL, Savage LM.
Neuroscience. 2021 Oct 1;473:52-65.
Male, but not female, Sprague Dawley rats display enhanced fear learning following acute ethanol withdrawal (hangover).
Marsland P, Parrella A, Vore AS, Barney TM, Varlinskaya EI, Deak T.
Pharmacol Biochem Behav. 2021 Sep;208:173229.
Syn3 Gene Knockout Negatively Impacts Aspects of Reversal Learning Performance.
Moore A, Linden J, Jentsch JD.
eNeuro. 2021 Sep 9;8(5):ENEURO.0251-21.2021.
Adolescent intermittent ethanol (AIE) produces sex specific alterations in adult neuroimmune gene expression and ethanol sensitivity that are independent of ethanol metabolism.
Vore AS, Barney TM, Gano A, Varlinskaya EI, Deak T.
Neuropharmacology. 2021 Sep 1;195:108635.
Midline Thalamic Damage Associated with Alcohol-Use Disorders: Disruption of Distinct Thalamocortical Pathways and Function.
Savage LM, Nunes PT, Gursky ZH, Milbocker KA, Klintsova AY.
Neuropsychol Rev. 2021 Sep;31(3):447-471.
Adolescent intermittent ethanol exposure does not alter responsiveness to ifenprodil or expression of vesicular GABA and glutamate transporters.
Dannenhoffer CA, Werner DF, Varlinskaya EI, Spear LP.
Dev Psychobiol. 2021 Jul;63(5):903-914.
Factors of sex and age dictate the regulation of GABAergic activity by corticotropin-releasing factor receptor 1 in the medial sub-nucleus of the central amygdala.
Rouzer SK, Diaz MR.
Neuropharmacology. 2021 May 15;189:108530.
Sex differences in cholinergic circuits and behavioral disruptions following chronic ethanol exposure with and without thiamine deficiency.
Kipp BT, Nunes PT, Savage LM.
Alcohol Clin Exp Res. 2021 May;45(5):1013-1027.
Executive functioning-specific behavioral impairments in a rat model of human third trimester binge drinking implicate prefrontal-thalamo-hippocampal circuitry in Fetal Alcohol Spectrum Disorders.
Gursky ZH, Savage LM, Klintsova AY.
Behav Brain Res. 2021 May 7;405:113208.
Genetic basis of susceptibility to low-dose paraquat and variation between the sexes in Drosophila melanogaster.
Lovejoy PC, Foley KE, Conti MM, Meadows SM, Bishop C, Fiumera AC.
Mol Ecol. 2021 May;30(9):2040-2053.
Moderate adolescent chronic intermittent ethanol exposure sex-dependently disrupts synaptic transmission and kappa opioid receptor function in the basolateral amygdala of adult rats.
Przybysz KR, Gamble ME, Diaz MR.
Neuropharmacology. 2021 May 1;188:108512.
Effects of pedunculopontine nucleus cholinergic lesion on gait and dyskinesia in hemiparkinsonian rats.
Chambers NE, Coyle M, Sergio J, Lanza K, Saito C, Topping B, Clark SD, Bishop C.
Eur J Neurosci. 2021 Apr;53(8):2835-2847.
Dopamine D3 Receptor Plasticity in Parkinson's Disease and L-DOPA-Induced Dyskinesia.
Lanza K, Bishop C.
Biomedicines. 2021 Mar 19;9(3):314.
Genetic suppression of the dopamine D3 receptor in striatal D1 cells reduces the development of L-DOPA-induced dyskinesia.
Lanza K, Centner A, Coyle M, Del Priore I, Manfredsson FP, Bishop C.
Exp Neurol. 2021 Feb;336:113534.
The effects of age, sex, and handling on behavioral parameters in the multivariate concentric square field™ test.
Gore-Langton JK, Werner DF, Spear LP.
Physiol Behav. 2021 Feb 1;229:113243.
Combined Knockout of Lrrk2 and Rab29 Does Not Result in Behavioral Abnormalities in vivo.
Mazza MC, Nguyen V, Beilina A, Karakoleva E, Coyle M, Ding J, Bishop C, Cookson MR.
J Parkinsons Dis. 2021;11(2):569-584.
Assessment of neuroinflammation in the aging hippocampus using large-molecule microdialysis: Sex differences and role of purinergic receptors.
Perkins AE, Piazza MK, Vore AS, Deak MM, Varlinskaya EI, Deak T.
Brain Behav Immun. 2021 Jan;91:546-55.
https://pubmed.ncbi.nlm.nih.gov/33166661/
2020
Kappa-opioid receptor-dependent changes in dopamine and anxiety-like or approach-avoidance behavior occur differentially across the nucleus accumbens shell rostro-caudal axis.
Pirino BE, Spodnick MB, Gargiulo AT, Curtis GR, Barson JR, Karkhanis AN.
Neuropharmacology. 2020 Dec 15;181:108341.
Moderate Adolescent Ethanol Vapor Exposure and Acute Stress in Adulthood: Sex-Dependent Effects on Social Behavior and Ethanol Intake in Sprague-Dawley Rats.
Gamble ME, Diaz MR.
Brain Sci. 2020 Nov 7;10(11):829.
Dopamine receptor cooperativity synergistically drives dyskinesia, motor behavior, and striatal GABA neurotransmission in hemiparkinsonian rats.
Kiessling CY, Lanza K, Feinberg E, Bishop C.
Neuropharmacology. 2020 Sep 1;174:108138.
Striatal Nurr1, but not FosB expression links a levodopa-induced dyskinesia phenotype to genotype in Fisher 344 vs. Lewis hemiparkinsonian rats.
Steece-Collier K, Collier TJ, Lipton JW, Stancati JA, Winn ME, Cole-Strauss A, Sellnow R, Conti MM, Mercado NM, Nillni EA, Sortwell CE, Manfredsson FP, Bishop C.
Exp Neurol. 2020 Aug;330:113327.
Adolescent Intermittent Ethanol Exposure Effects on Kappa Opioid Receptor Mediated Dopamine Transmission: Sex and Age of Exposure Matter.
Spodnick MB, Amirault RT, Towner TT, Varlinskaya EI, Spear LP, Karkhanis AN.
Brain Sci. 2020 Jul 23;10(8):472.
Ethanol Stimulation of Microglia Release Increases ERK1/2-Dependent Neuronal cPLA2 Activity in Immature Cultured Cortical Preparations.
Santerre-Anderson JL, Werner DF.
Neurochem Res. 2020 Jul;45(7):1592-1601.
Lingering effects of prenatal alcohol exposure on basal and ethanol-evoked expression of inflammatory-related genes in the CNS of adolescent and adult rats.
Doremus-Fitzwater TL, Youngentob SL, Youngentob L, Gano A, Vore AS, Deak T.
Front Behav Neurosci. 2020 Jun 29;14-82.
Characterization of genetically complex Collaborative Cross mouse strains that model divergent locomotor activating and reinforcing properties of cocaine.
Schoenrock SA, Kumar P, Gómez-A A, Dickson PE, Kim SM, Bailey L, Neira S, Riker KD, Farrington J, Gaines CH, Khan S, Wilcox TD, Roy TA, Leonardo MR, Olson AA, Gagnon LH, Philip VM, Valdar W, de Villena FP, Jentsch JD, Logan RW, McClung CA, Robinson DL, Chesler EJ, Tarantino LM.
Psychopharmacology (Berl). 2020 Apr;237(4):979-996.
Adolescent forced swim stress increases social anxiety-like behaviors and alters kappa opioid receptor function in the basolateral amygdala of male rats.
Varlinskaya EI, Johnson JM, Przybysz KR, Deak T, Diaz MR.
Prog Neuropsychopharmacol Biol Psychiatry. 2020 Mar 2;98:109812.
General Anesthetic Exposure During Early Adolescence Persistently Alters Ethanol Responses.
Landin JD, Gore-Langton JK, Varlinskaya EI, Spear LP, Werner DF.
Alcohol Clin Exp Res. 2020 Mar;44(3):611-619.
Age and sex regulate kappa opioid receptor-mediated anxiety-like behavior in rats.
Przybysz KR, Varlinskaya EI, Diaz MR.
Behav Brain Res. 2020 Feb 3;379:112379.
Pedunculopontine Nucleus Degeneration Contributes to Both Motor and Non-Motor Symptoms of Parkinson's Disease.
Chambers NE, Lanza K, Bishop C.
Front Pharmacol. 2020 Jan 15;10:1494.
Effects of chronic intermittent ethanol exposure during early and late adolescence on anxiety-like behaviors and behavioral flexibility in adulthood.
Varlinskaya EI, Hosová D, Towner T, Werner DF, Spear LP.
Behav Brain Res. 2020 Jan 27;378:112292.
Reciprocal cross-sensitization of D1 and D3 receptors following pharmacological stimulation in the hemiparkinsonian rat.
Lanza K, Chemakin K, Lefkowitz S, Saito C, Chambers N, Bishop C.
Psychopharmacology (Berl). 2020 Jan;237(1):155-165.
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