* indicates graduate student, †indicates undergraduate student

2024

O'Brien, K.M., Rix, A.S., Jasmin, A.†, and E. Lavelle (2024). The hypoxia response pathway in the Antarctic fish Notothenia coriiceps is functional despite a poly Q/E insertion mutation in HIF-1α. Accepted, Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics

2022

O’Brien, K.M., Crockett, E.L., et al. (+ 21 co-authors) (2022). The time is right for an Antarctic Biorepository network. Proc. Natl. Acad. Sci. 119 (50) e2212800119.

Cominassi, L., Ressel, K.N., Brooking, A.A., Marbacher, P.†, Ransdell-Green, E.C.† and K.M. O’Brien (2022) Metabolic rate increases with acclimation temperature and is associated with mitochondrial function in some tissues of threespine stickleback. J. Exp. Biol. 225 (21): jeb244659.

O’Brien, K.M., Oldham, C.A.*, Sarrimanolis, J.†, Fish, A. †, Castellini, L., Vance, J.†,  and E.L. Crockett (2022). Warm acclimation alters antioxidant defenses but not metabolic capacities in the Antarctic fish, Notothenia coriiceps. Conserv. Physiol. 10 (1). 

Ressel, K.N., Cominassi, L., Sarrimanolis, J.†, and K.M. O’Brien (2022). Aerobic scope is not maintained at low temperature and is correlated with cardiac aerobic capacity in the threespine stickleback Gasterosteus aculeatus.  J. Fish Biol. 100(2) 444-453.

2021

O’Brien, K.M., Joyce, W., Crockett, E.L., M. Axelsson Egginton, S., and A.P. Farrell (2021). Resilience of cardiac performance in Antarctic notothenioid fishes in a warming climate. J. Exp. Biol. 224 (10).

Biederman, A.*, O’Brien, K.M., and E.L. Crockett (2021). Homeoviscous adaptation occurs with thermal acclimation in biological membranes from heart and gill, but not the brain, in the Antarctic fish Notothenia coriiceps. J. Comp. Physiol. B.

Evans, E.E. *, Farnoud, A., O’Brien, K.M., and E.L. Crockett (2021). Thermal profiles reveal stark contrasts in properties of biological membranes from heart among Antarctic notothenioid fishes which vary in expression of hemoglobin and myoglobin. Comp. Biochem. Physiol. B.

2020 

O’Brien, K.M., Rix, A.S.*, Grove, T., Sarrimanolis, J. † Brookings, A.†, Roberts, M., and E.L. Crockett, (2020). Characterization of the hypoxia-inducible factor-1 pathway in hearts of Antarctic notothenioid fishes. Comp. Biochem. Physiol. B., 250:110505.  

2019

Egginton, S.E., Axelsson, M., Crockett, E.L., O’Brien, K.M., and A.P. Farrell. (2019). Nature’s knockouts:  Maximum in situ cardiac performance at ambient and elevated temperatures in Antarctic fishes lacking haemoglobin and myoglobin. Conserv. Physiol.  7(1).

Biederman, A.M.*, Kuhn, D.E., O’Brien, K.M., and E.L. Crockett. (2019). Mitochondrial membranes in cardiac muscle from Antarctic notothenioid fishes vary in phospholipid composition and membrane fluidity. Comp Biochem. Physiol. B 235:46-53.

Biederman, A.M.*, Kuhn, D.E., O’Brien, K.M., and E.L. Crockett. (2019). Physical, chemical, and functional properties of neuronal membranes vary between species of Antarctic notothenioids differing in thermal tolerance. J. Comp Physiol. Biochem. 189(2) 213-222.

2018

Joyce, W.*, Axelsson, M., Egginton, S.E., Farrell, A.P., Crockett, E.L., and K.M. O’Brien. (2018). The effects of thermal acclimation on cardio-respiratory performance in an Antarctic fish (Notothenia coriiceps). Conserv. Physiol. 6(1)

Joyce, W.*, Egginton, S., Farrell, A. P., Crockett, E.L., O’Brien, K.M., and M. Axelsson. (2018). Exploring nature’s natural knockouts: In vivo cardiorespiratory performance of Antarctic fishes during acute warming. J. Exp. Biol. 221.

O’Brien, K.M., Rix, A.S.*, Egginton, S., Farrell, A.P., Crockett, E.L., Schlauch, K., Woolsey, R., Hoffman, M., and S.E. Merriman†. (2018). Mitochondrial metabolism may contribute to differences in thermal tolerance of red- and white-blooded Antarctic notothenioid fishes. J. Exp. Biol. 221.

O’Brien, K.M., Crockett, E.L., Philip, J., Oldham, C.A.*, Hoffman, M., Kuhn, D.E., Barry, R., and J. McLaughin†. (2018). The loss of hemoglobin and myoglobin does not confer an advantage in management of oxidative stress in Antarctic icefishes. J. Exp. Biol. 221.

2017 

Rix, A.S.*, Grove, T.J., and K.M. O’Brien. (2017). Hypoxia-inducible factor-1a in Antarctic fishes contains a polyglutamine and glutamic acid insert that varies in length with phylogeny. Polar Biol. 40(12) 2537-2545.

Ainley, D.A., Crockett, E., Eastman, J.E., Fraser, W., Nur, N., O’Brien, K., Salas, L., Siniff, D. (2017). How overfishing a large piscine mesopredator explains growth in Ross Sea penguin populations: a framework to better understand impacts of a controversial fishery. Ecolog. Model.

Keenan, K.A.*, Grove, T.J., Oldham, C. A.*, and K.M. O’Brien (2017). Characterization of glycerol-3-phosphate acyltransferase in notothenioid fishes. Comp. Biochem. Physiol. Part B 204: 9-26.

Keenan, K.*, Hoffman, M., Dullen K.†, and K.M. O’Brien (2017). Molecular drivers of membrane proliferation in response to cold acclimation in threespine stickleback. Comp. Biochem. Physiol. Part A. 203: 109-114.

2016

O'Brien, K.M. (2016). New lessons from an old fish: what Antarctic icefishes may reveal about the functions of oxygen-binding proteins Integr Comp Biol. 56: 531-41.

Kuhn, D.E., O'Brien, K.M., and E. L. Crockett (2016). Expansion of capacities for iron transport and sequestration reflects plasma volumes and heart mass among white-blooded notothenioids. Am J Physiol Regul Integr Comp Physiol. 311: R649- R657

Devor, D.P.*, Kuhn, D.E., O’Brien, K.M., and E.L. Crockett (2016). Hyperoxia does not extend critical thermal maxima (CTMax) in white- or red-blooded Antarctic notothenioid fishes. Physiol. Zool. 89: 1-9.

2015

Teigen, L.E*., Orczewska, J.I*., McLaughlin, J. †, and K.M. O’Brien (2015). Cold acclimation increases levels of some heat shock proteins and sirtuin isoforms in threespine stickleback. Comp. Biochem. Physiol. Part A. 188: 139-148.

Lewis, J.M., Grove, T.J., and K.M. O’Brien (2015). Energetic costs of protein synthesis do not differ between red- and white- blooded Antarctic notothenioid fishes. Comp. Biochem. Physiol. Part A. 187: 177-183.

2014 

O’Brien, K.M., Mueller, I.A.*, Orczewska, J.I.*, Dullen, K.R.†, and M. Ortego† (2014). Hearts of some Antarctic fishes lack mitochondrial creatine kinase. Comp. Biochem. Physiol. Part A. 178: 30-36.

Mueller, I.A.*, Hoffmann, M., Dullen, K†., and K.M. O’Brien (2014). Moderate elevations in temperature do not increase oxidative stress in oxidative muscles of Antarctic notothenioid fishes. Polar Biol. 37: 311-320.

2013

O'Brien, K.M. and E.L. Crockett (2013). The promise and perils of Antarctic fishes. EMBO Rep. 14: 17-24.

Woo, D.K., Jung, Y.W., O’Brien, K.M., and R.O. Poyton (2013). Molecular characterization of a mitochondrial mutant carrying point mutations in the 3’ untranslated region of COX3 mRNA from Saccharomyces cerevisiae. Animal Cell Sys 17: 80-87.

2012

Mueller, I.A.*, Devor, D.P, Grim, J.M., Beers, J.M., Crockett, E.L., and K.M. O'Brien (2012). Exposure to critical thermal maxima causes oxidative stress in hearts of white-but not red-blooded Antarctic notothenioid fishes. J. Exp. Biol. 215: 4655-3664. 

2011

Mueller, I.A*., and K.M. O'Brien (2011). Nitric oxide synthase is not expressed, nor up-regulated in response to cold acclimation in liver or muscle of threespine stickleback (Gasterosteus aculeatus). Nitric Oxide. 25: 416-422.

Mueller*, I.M., Grim, J., Beers, J., Crockett, E.L., and K.M. O’Brien (2011). Interrelationship between mitochondrial function and susceptibility to oxidative stress in red- and white-blooded Antarctic notothenioid fishes. J. Exp. Biol. 214: 3732-3741

 Kammer*, A.R., Orczewska*, J.I., and K.M. O’Brien (2011). Oxidative stress is transient and tissue-specific during cold acclimation of threespine stickleback. J. Exp. Biol. 214: 1248-1256

 O’Brien, K.M. (2011). Mitochondrial biogenesis in cold-bodied fishes. J. Exp. Biol.   214: 275-285.

2010

O’Brien, K.M., and I. Mueller* (2010). The unique mitochondrial form and function of Antarctic channichthyid icefishes. Integ. Comp. Physiol. 50(6):993-1008.

Orczewska*, J.I., Hartleben*, G., and K.M. O’Brien. (2010). The molecular basis of aerobic metabolic remodeling differs between oxidative muscle and liver in threespine sticklebacks in response to cold acclimation. Am J Physiol Regul Integr Comp Physiol 299: R352-64.

2009

Urschel*, M., and K.M. O’Brien. (2009). Mitochondrial function in Antarctic notothenioid fishes that differ in the expression of oxygen-binding proteins. Polar Biol. 32: 1323-1330.

2008

Urschel*, M., and K.M. O’Brien. (2008). High mitochondrial densities in hearts of Antarctic icefishes are maintained by an increase in mitochondrial size, rather than mitochondrial biogenesis. J. Exp. Biol. 211:2638-2646.

2006

Sidell, B.D., and K.M. O’Brien. (2006). When bad things happen to good fish: the loss of hemoglobin and myoglobin expression in Antarctic icefishes. J. Exp. Biol. 209: 1791-1802.

2005

Cassanova, N., O'Brien, K.M., Stahl, B., McClure, T., and R. O. Poyton. (2005). Yeast flavohemoglobin, a nitric oxide oxidoreductase, is located in both the cytosol and mitochondrial matrix: Effects of respiration, anoxia, and the mitochondrial genome on its intracellular level and distribution. J. Biol. Chem. 280: 7645-7653.

2004

O’Brien, K.M., Dirmeier, R., Engle, M., and R.O. Poyton. (2004). Mitochondrial protein oxidation in yeast mutants lacking Mn or CuZn superoxide dismutase: Evidence that MnSOD and CuZnSOD have both unique and overlapping functions in protecting mitochondrial proteins from oxidative damage. J. Biol. Chem. 279: 51817-51827.

Dirmeier, R., O'Brien, K.M., Engle, M., Dodd, A., Spears, E., and R.O. Poyton. (2004). Measurement of oxidative stress in cells exposed to hypoxia and other changes in oxygen concentration. Meth. Enzymol. 381:589-603.

Poyton, R.O., Dirmeier, R., O'Brien, K.M., David, P., and A. Dodd. (2004). Experimental strategies for analyzing oxygen sensing in yeast. Meth. Enzymol. 381: 644-662.

2003

Poyton, R.O., Dirmeier, R., O'Brien, K.M., and E. Spears. (2003). A role for the mitochondrion and reactive oxygen species in oxygen sensing and adaptation to hypoxia in yeast. In: Oxygen Sensing:Responses and Adaptation to Hypoxia. Editors: Lahiri, S., Semenza, G., and N. Prabhakar. Marcel Dekker Inc., N.Y., Basel.

O'Brien, K.M., Skilbeck, C., Sidell, B.D., and S. Egginton. (2003). Muscle fine structure may maintain the function of oxidative muscle fibres in haemoglobinless Antarctic fishes. J. Exp. Biol. 206: 411-421.

2002

Dirmeier, R., O'Brien, K.M., Engle, M., Dodd, A., Spears, E., and R.O. Poyton. (2002). Exposure of yeast cells to anoxia induces transient oxidative stress. J. Biol. Chem. 277: 34773-34789.

2001

Dagsgaard, C., Taylor, L., O'Brien, K.M., and R.O. Poyton. (2001). Effects of anoxia and the mitochondrion on expression of aerobic nuclear COX genes in yeast: Evidence for a signaling pathway from the mitochondrial genome to the nucleus. J. Biol. Chem. 276: 7593-7601.

2000

O'Brien, K.M., and B.D. Sidell. (2000). The interplay among cardiac ultrastructure, metabolism and the expression of oxygen-binding proteins in Antarctic fishes. J. Exp. Biol. 203: 1287-1297.

O'Brien, K.M., Xue, H., and B.D. Sidell. (2000). Quantification of oxygen diffusion distance within the spongy myocardium of hearts from Antarctic fishes. Resp. Physiol. 122:71-80.

1998

McCleave, J.D., Brickley, P.J., O'Brien, K.M., Kistner, D.A., Wong, M.W., Gallagher, M. and  S.M. Watson. (1998). Do leptocephali of the European eel swim to reach continental waters? Status of the question. J. Mar. Biol. Ass. U.K. 78:285-306.

1997

O'Brien, K.M., and B.D. Sidell. (1997). The loss of hemoglobin and/or myoglobin affects cardiac ultrastructure in Antarctic fishes. Antarc. J. U.S. 32:98-100.