Brain Organoids

Cortex

Cortical organoids are generated from neural precursor cells. Is a serum-free 4 stages protocol, including embryoid bodies formation, neuroepithelial expansion, differentiation and maturation up to 4-5 months. During the organoid development you can face the expression of the main developmental brain markers like PAX6, SOX2, p-Vimentin, as well as the markers for the intermediate zone (TBR2+), and cortical plate (CTIP2, MAP2, TBR1).  [Price inquire]

Midbrain

We generate human midbrain organoids from neural precursor cells activating the Wnt and Shh pathway by small molecules. The protocol is a 5 stages protocol, beginning with embryoid body formation step followed by expansion of neuroepithelia, prepatterning, patterning and maturation stages. Midbrain organoids asume their maturation starting from 60 days in culture including functional dopaminergic neurons. [Price inquire]

Neuromuscular

Neuromuscular organoids are generated starting from preconditioned neuro-mesodermal progenitor cells. Neuromuscular organoids are polarized organoids with the neural region innervating the muscular region. They can be used to model Multiple Sclerosis, Amyotrophic Lateral Sclerosis and any neuromuscular degenerative diseases. [Price inquire]