HSCGE Core Homepage

Welcome to The Human Stem Cell and Gene Editing (HSCGE) CoreThe HSCGE core was formed in 2015 to support neuroscience research using state-of-the-art stem cell and gene editing technologies. The core is located on the 5th floor of BSRB and is a full service facility to support the research programs of faculty across the UM campus. Dr. Jack Parent (Neurology & MNI) serves as director, and Dr. Michael Uhler (MNI & Biological Chemistry) serves as co-director of the core. The HSCGE core is dedicated to provide neuroscience research community valuable new sources of human pluripotent stem cells (hPSCs) for basic research, drug discovery, or cell therapy. We offer a wide-range of services including but not limited to derivation of induced pluripotent stem cells (iPSCs) from fibroblasts or blood cells, CRISPR/Cas9-mediated gene editing hPSCs, monolayer differentiation of hPSCs, cerebral organoid differentiation of hPSCs, and training for hPSC maintenance. A detailed description of each service can be found on the "Services & Fees" page of our website. These services are available to both internal and external research organizations.

Shall you be interested in services offered in the HSCGE core or seeking for potential collaborations, please contact Dr. Rouknuddin Ali (aliro@med.umich.edu) for further details.