Program

The 2024 program is now available for Download. This year's Keynote presentation is Prof. Benjamin Garcia, “Quantitative Proteomics for Understanding Epigenetics Mechanisms”. 

Conference Schedule

Session A (Rm 1001) 9:00 am – noon (Chemical Biology)

A1. PsychedelCLicKs – Understanding Mechanism of Action through Clickable Psychedelics

Amy Chabroux, Andras Domokos, Lauren S. Arias, Arabo A. Avanes, Joseph Benetatos, Loren L. Looger, David E. Olson

A2. Targeted Intervention: Discovery of ADAR Guide RNA via Large Library Screen for Correcting the C-Terminal MeCP2 Frameshift Mutation Linked to Rett Syndrome

Megan Chinn, Prince Salvador, Sherry Lin and Peter A. Beal

A3. Harnessing ADAR Therapeutic Potential: Cellular Repair of MeCP2 Mutation Linked to Rett Syndrome with a Fully Sugar Modified Guide RNA

Sherry Lin, Prince Salvador, Megan Chinn, and Peter A. Beal

A4. Correlation of MUTYH Expression and OG:A Repair Capacity in the MUTYH Zn2+ Coordinating Residue Mutants

Zhe Cao, Tian Xia, Melody Malek, Sheila S. David

A5. The Effect of Oxidative Stress on the Expression and Repair Capacity of NEILs 1, 2, and 3

Ethan Hintz, Melody Malek, Alessandra Beelen, Mohammad Hashemian, Joshua D. Bumgarner, Sheila S. David

A6. Synthesizing Nucleic Acid Based Inhibitors of the BER glycosylases MUTYH and hOGG1

Ruoh Yu Chan, Melody Malek, Sydney Figueroa, Alessandra Beelen, Mohammad Hashemian, Carlos Trasvina Arenas, Sheila S. David

A7. Stepwise One-Pot Multienzyme (StOPMe) Strategy for Chemoenzymatic Synthesis of Human Milk Oligosaccharide-Based Glycan Probes

Wenrui Chen, Yue Yuan, Zimin Zheng, Xi Chen

A8. Chemoenzymatic Strategies for Highly Efficient Gram-Scale Synthesis of Human Milk Oligosaccharides (HMOs)

Yijun Wei, Zimin Zheng, Xiaohong Yang, Anand Kumar Agrahari, Xi Chen

A9. Calmodulin Binding to Cytosolic Regulatory Sites of the NMDA Receptor Promotes Ca2+-dependent Channel Inactivation

Isaac Yu, Aritra Bej, James B. Ames

A10. Progress Towards the Cryo-EM Structure Determination of Adenosine Deaminase Acting on RNA (ADAR)

Srinidhi Venkatesh, Sukanya Mozumder, Andrew Fisher

A11. Investigating the Role of a Conserved Histidine in the RNA binding domains of ADAR2 on RNA Editing Efficiency

Katherine Htut, Ysabella Mello, Andrew Fisher

A12. Copper-Mediated Aggregation of Bovine Serum Albumin and Insulin Prohormone C-peptide

Justine Reyes Retana, Rebeca L. Fernandez, Marie C. Heffern

A13. Utilizing Cyanobacteria within Engineered Living Systems

Twisha Dasgupta, Jayce Taylor, Nhu Tong, Jada Bezue, and Shota Atsumi

A14. Structural Analysis of Cytosolic Proximal and Distal Regulatory Domains in the L-type Voltage-gated Ca2+ channel

William P. Pryor, David E. Anderson, Deepak Kumar Yadav, James B. Ames

A15. Characterizing Functional Parameters of BglB Variants to Improve Computational Enzyme Algorithm Development

Jennifer Lee, Ashley Vater, Justin Siegel

Session B (Rm 1002) 9:00 am – noon (Organic/Inorganic Chemistry)

B1. Ni(I) and Ni(II) Bis(trimethylsilyl)amides Obtained in Pursuit of the Elusive Structure of Ni{N(SiMe3)2}2

Anthony J. Witt, Connor P. McLoughlin, Philip P. Power

B2. Comparison of Ionic and Molecular Dimers of Au2DPPM2Br2

Katelyn Espinoza, Sarah Chui, Sarah Costa, and Alan Balch

B3. Bi-nuclear Gold Complex with 2-and 3-Coordinate Gold

Sarah Chui, Sarah Costa, Thu Nguyen, Katelyn Espinoza, Alan L. Balch

B4. Exploring Reactive Capture of CO2 Using Molecular Electrocatalysts

Yiming Liu, Santanu Pattanayak, James C. Fettinger, Rachel Elizabeth Siegel, Louise A. Berben

B5. Synthesis of Carbacycles by C–H insertion of Donor/Donor Carbenes

Tania Shahvali, José Manuel Ruiz, Dylan R. Turner, Mingchun Gao, Emily Jimenez, Jared T. Shaw

B6. Applications of C–H Insertion to Complex Natural Product Scaffolds

Samantha L. Mayer, Matthew W. Dyer, Yuan-Shin (Jack) Shiue, Jared T. Shaw

B7. Exploring Strain-Release Pentafluorosulfanylation of [1.1.0]Bicyclobutanes

Ansh Hiten Patel, Jón Atiba Buldt, Cody Ross Pitts

B8. Advancements in Pentafluorosulfanylation Using SF5Cl

Zane Haidar, Yannick Kraemer, Cody Ross Pitts

B9. Evaluation of Chemoselectivity and Regioselectivity in the Hydrosilylation of Alkenoate Substrates

Wendy Tran, Leah Thompson, Annaliese Franz

B10. Synthesis and assessment of silylated N-acyl homoserine lactones’ self-assembly in aqueous media

Cole C. Dickson, Linnea S. Dolph, Emma E. Santa, Kelsey M. Mesa, Irene M Stoutland, Helen E. Blackwell, and Annaliese K. Franz

B11. On the Importance of Commercial Chlorogenic Acid Compound Verification

Lauren Leyva, William Ristenpart, Jacquelyn Gervay-Hague

B12. Synthesis of Entropy-Stabilized Oxides Through Sterical Entrapment

Hani Sobhi and Scott McCormack

B13. Synthesis of a Trifunctional biotinylated disulfide cross-linker to mediate glycomic interactions

Shivraj Singh Gill, Michael Russelle Alvarez, Riya Gogte, Carlito Lebrilla

B14. Studying the Influence of Time Devoted to Practice Questions on the Problem-Solving Abilities of Students in General Chemistry

Neha Gondra, Sloka Suresh, Stephanie Toy, Auddy Anilao, Sandhya B. Pfile, Brandon J. Vernoy, Josh M.Y. Lee, Rachana Raghavendra, Akshaya Ravi, Ozcan Gulacar

Session C (Rm 1003) 9:00 am – noon (Physical/Analytical/Computational Chemistry)

C1. High Pressure Structural Phase Transitions in Silicon Telluride

Bohan Li, Frank Cerasoli, Ethan Chen, Martin Kunz, Davide Donadio, Kristie J. Koski

C2. Investigating the Intramolecular Dynamics of Vinyl-substituted Nitrogen Heterocycles Using Rotational Spectroscopy

Agnes Pek, Chisom Adaobi Dim, Yi Hsin, Madison R Smith, Kyle N Crabtree

C3. Sugar Metabolism in Cells using Proteomics and Isotope labeling

Jaime F. Silva, Michael Russelle Alvarez, Sheryl Joyce Grijaldo-Alvarez, Tristan Seales, Carlito B. Lebrilla

C4. Substitutional Doping of Selenium in Si2Te3

Ethan Chen and Kristie J. Koski

C5. Raman spectroscopy of low temperature phase transitions of intercalated CrCl3

Charlotte Cook and Kristie J. Koski

C6. Effects of cell immortalization on protein N-glycosylation

Anirudh Yadlapati, Michael Russelle Alvarez, Patrick Moreno, Sheryl Joyce Grijaldo-Alvarez, Francisco Heralde III, Carlito B. Lebrilla

C7. Measuring Glycosylation Enzyme Activity Alterations in Brain Cancer via LC-MS

Andrea K. Keys, Xavier A. Holmes, Carlito B. Lebrilla

C8. Structural Elucidation of N-Glycans by Collision-Induced Dissociation and Chromatographic Elution Patterns using nanoflow HPLC-Q/ToF and Glycoproteomic analysis with Orbitrap Mass Spectrometry

Tristan Seales, Ryan Schindler, Sheryl Joyce Grijaldo-Alvarez, Michael Russelle Alvarez, Carlito B. Lebrilla

C9. Rotational Spectroscopy of Cyclic Amides

Yi Hsin, Chisom A. Dim, Agnes Pek, Madison Smith, Kyle N. Crabtree

C10. Pressure profiling of argon and helium de Laval nozzles for use in astrochemical molecular kinetics experiments

Cedric Centers, Huanyu Ren, Junwei He, Jonathan Fong, Adam Culick, Kyle Crabtree

C11. Rotational Spectroscopy of N-Acetyl-2-Pyrrolidone and Acetylcaprolactam: Investigation of Internal Motions

Madison R. Smith, Chisom Adaobi Dim, Yi Hsin, Agnes Pek, Kyle N. Crabtree

C12. Method for Experimental Validation of Theoretical Glycan Structures from Structure Repositories

Erin K. Morissette, Xavier A. Holmes, Yasmine Bouchibti, Carlito B. Lebrilla

C13. Mapping Bacterial Metabolism to Glycomic Profile Shifts in Sauerkraut Fermentation via LC-MS

Graceanna K. Wibisono, Shawn Ehlers Cheang, Charlie Weng, Nicholas Cheng, Carlito B. Lebrilla

C14. Comprehensive Analysis with Quantitation of Human Milk Oligosaccharides

Kalyn Amezcua, Aaron Stacy, Carlito Lebrilla

C15. Searching for proton transfer channels in cytochrome c oxidase

June Hyun Lee, Alexei Stuchebrukov

Keynote Address 1:15 AM – 2:15 PM: Prof Benjamin Garcia (Raymond H. Wittcoff Distinguished Professor, Washington University School of Medicine)

Abstract: Histones are proteins that package DNA into chromosomes, and several post-translational modification (PTM) sites on histones are associated with gene activation and silencing. Histone PTMs make up epigenetic mechanisms that control gene expression patterns outside of DNA se-quence mutations. Dysregulation of these chromatin networks underlie several human diseases such as cancer. Here I will give an update on technology advancements that have allowed for high-throughput quanti-tative mass spectrometry analyses of histone PTMs and chromatin struc-ture, and how we are applying these methods to understand epigenetic reprogramming found in malignant peripheral nerve sheath tumors (MPNSTs). MPNST is an aggressive sarcoma with recurrent loss of func-tion alterations in polycomb-repressive complex 2 (PRC2), a histone-modifying complex involved in transcriptional silencing.