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Researchers at the University of Alberta
AM James Shapiro
Post-transplant characterization of long-term functional hESC-derived pancreatic endoderm grafts Pepper AR et al Diabetes 65:953, 2019
Improved islet recovery and efficacy through co-culture and co-transplantation of islets with human adipose-derived mesenchymal stem cells Gamble A et al PLoS One 13:e0206449, 2018
BMX-001, a novel redox-active metalloporphyrin, improves islet function and engraftment in a murine transplant model Bruni A et al Am J Transplant 18:1879, 2018
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Transplantation of human pancreatic endoderm cells reverses diabetes post transplantation in a prevascularized subcutaneous site Pepper AR et al Stem Cell Rep 8:1689, 2017
Long-term function and optimization of mouse and human islet transplantation in the subcutaneous device-less site Pepper A et al Islets 8:186, 2016
A novel pre-vascularized subcutaneous site safely accommodates stem cell derived therapies for treating diabetes Gala-Lopez B et al J Stem Trans Biol 2:270000107, 2016
Lung-derived microscaffolds facilitate diabetes reversal after mouse and human intraperitoneal islet transplantation Abualhassan N et al PLoS One 1:e0156053, 2016
Anti-aging glycopeptide protects human islets against tacrolimus-related injury and facilitates engraftment in mice Gala-Lopez BL et al Diabetes 65:451, 2016
A prevascularized subcutaneous 'Device-Less' site for islet and cellular transplantation Pepper A et al Nat Biotechnol 33:518, 2015
Glutathione ethyl ester supplementation during pancreatic islet isolation improves viability and transplant outcomes in a murine marginal islet mass model Raposo do Amaral AS et al PLoS One 8:e55288, 2013
Anakinra potentiates the protective effects of etanercept in transplantation of marginal mass human islets in immunodeficient mice McCall M et al Am J Transplant 12:322, 2012
AEB071 (sotrastaurin) does not exhibit toxic effects on human islets in vitro, nor after transplantation into immunodeficient mice Merani S et al Islets 3:338, 2011
The caspase inhibitor IDN-6556 (PF3491390) improves marginal mass engraftment after islet transplantation in mice McCall M et al Surgery 150:48, 2011
Human islet distribution program for basic research at a single center Kin T et al Transplant Proc 43:3195, 2011
Liraglutide, a long-acting human glucagon-like peptide 1 analogue, improves human islet survival in culture Toso C et al Transplant Int 23:259, 2010
The caspase selective inhibitor EP1013 augments human islet graft function and longevity in marginal mass islet transplantation in mice Emamaullee JA et al Diabetes 57:1556, 2008
Patrick MacDonald
Molecular correlates of glycine receptor activity in human β cells Gomes AS et al Mol Metab 2025
TMEM55A-mediated PI5P signaling regulates α-cell actin depolymerization and glucagon secretion Liu X et al Diabtologia 2025
Ca2+ oscillations, waves, and networks in islets from human donors with and without type 2 diabetes Gosak M and Yan-Do R et al Diabetes 71:2584, 2022
Heterogenous impairment of α-cell function in type 2 diabetes is linked to cell maturation state Dai X-Q et al Cell Metab 34:256, 2022
A role for PKD1 in insulin secretion downstream of P2Y1 receptor activation in mouse and human islets Khan S et al Physiol Rep 7:e14250, 2019
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Kv2.1 clustering contributes to insulin exocytosis and rescues human β-cell dysfunction Fu J et al Diabetes 66:1890, 2017
STEAP4 expression in human islets is associated with differences in body mass index, sex, HbA1c, and inflammation Gordon HM et al Endocrine 56:528, 2017
SUMOylation and calcium control syntaxin-1A and secretagogin sequestration by tomosyn to regulate insulin exocytosis in human ß cells Ferdaoussi M et al Sci Rep 7:248, 2017
PI3 kinases p110α and PI3K-C2β negatively regulate cAMP via PDE3/8 to control insulin secretion in mouse and human islets Kolic J et al Mol Metab 5:459, 2016
A glycine-insulin autocrine feedback loop enhances insulin secretion from human β-cells and is impaired in type 2 diabetes Yan-Do R et al Diabetes 65:2311, 2016
Interleukin-1 signaling contributes to acute islet compensation Hajmrle C et al JCI Insight 1:e86055, 2016
Research-focused isolation of human islets from donors with and without diabetes at the Alberta Diabetes Institute IsletCore Lyon J et al Endocrinology 157:560, 2016
TCF1 links GIPR signaling to the control of beta cell function and survival Campbell JE et al Nat Med 22:84, 2016
Rp-cAMPS prodrugs reveal the cAMP dependence of first-phase glucose-stimulated insulin secretion Schwede F and Chepurny OG et al Mol Endocrinol 29:988, 2015
Transcript expression data from human islets links regulatory signals from genome-wide association studies for type 2 diabetes and glycemic traits to their downstream effectors van de Bunt M and Manning Fox JE et al PLoS Genet 11:e1005694, 2015
Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional beta cells Ferdaoussi M and Dai X et al J Clin Invest 125:3847, 2015
Human islet function following 20 years of cryogenic biobanking Manning Fox JE et al Diabetologia 58:1053, 2015
Insulin secretion induced by glucose-dependent insulinotropic polypeptide requires PI3 kinase-γ in rodent and human β cells Kolic J et al J Biol Chem 289:32109, 2014
SUMOylation protects against IL-1β-induced apoptosis in INS-1 832/13 and human islets Hajmrle C et al Am J Physiol Endocrinol Metab 307:E664, 2014
SUMO1 enhances cAMP-dependent exocytosis and glucagon secretion from pancreatic α-cells Dai XQ et al J Physiol 592:3715, 2014
Triton X-100 inhibits L-type voltage-operated calcium channels Narang D et al Can J Physiol Pharmacol 91:316, 2013
Distinct and opposing roles for the phosphatidylinositol 3-OH kinase catalytic subunits p110α and p110β in the regulation of insulin secretion from rodent and human beta cells Kolic J et al Diabetologia 56:1339, 2013
Functional plasticity of the human infant beta-cell exocytotic phenotype Manning Fox JE et al Endocrinology 154:1392, 2013
The voltage-dependent potassium channel subunit Kv2.1 regulates insulin secretion from rodent and human islets independently of its electrical function Dai XQ et al Diabetologia 55:1709, 2012
SUMOylation regulates insulin exocytosis downstream of secretory granule docking in rodents and humans Dai XQ et al Diabetes 60:838, 2011
Voltage-dependent K+ channels are positive regulators of alpha cell action potential generation and glucagon secretion in mice and humans Spigelman AF et al Diabetologia 53:1917, 2010
Inhibition of beta-cell sodium-calcium exchange enhances glucose-dependent elevations in cytoplasmic calcium and insulin secretion Hamming KSC et al Diabetes 59:1686, 2010
Kiss-and-run exocytosis and fusion pores of secretory vesicles in human β-cells Hanna ST et al Pflugers Arch 457:1343, 2009
SUMOylation regulates Kv2.1 and modulates pancreatic β-cell excitability Dai XQ et al J Cell Sci 122:775, 2009
Insulin granule recruitment and exocytosis is dependent on p110γ in insulinoma and human β-cells Pigeau GM et al Diabetes 58:2084, 2009
Greg Korbutt
Identification and differentiation of PDX-1 beta-cell progenitor within human pancreatic epithelium Seeberger et al World J Diabetes 5:59, 2014
Immunohistochemical characterization of insulin, glucagon, PDX1, SOX17 and NGN3 expression in human fetal pancreatic development Anderson SJ et al J Stem Cell Res Ther 3:4, 2013
Human mesenchymal stem cells protect islets from pro-inflammatory cytokines Yeung TY et al PLoS One 7:e38189, 2012
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Epithelial cells within the human pancreas do not coexpress mesenchymal antigens: epithelial-mesenchymal transition is an artifact of cell culture Seeberger KL et al Lab Invest 89:110, 2009
Matthias Braun
Autocrine activation of P2Y1 receptors couples Ca2+ influx to Ca2+ release in human pancreatic beta cells Khan S and Yan-Do R et al Diabetologia 57:2525, 2014
Peter Light
Human islets contain a subpopulation of glucagon-like peptide-1 secreting α cells that is increased in type 2 diabetes Campbell SA et al Mol Metab 39:101014, 2020
The DPP4 inhibitor sitagliptin increases active GLP-1 levels from human islets and may increase islet cell survival prior to transplantation Campbell SA et al OBM Transplantation 3:14, 2019
Andrew Pepper
Nanothin onformal coating with poly(N-vinylpyrrolidone) and tannic acid (PVPON/TA) preserves murine and human pancreatic islets function Polishevska K et al Pharmaceutics 15:1137, 2023
Researchers National / International
Jun Shirakawa (Gunma University, Japan)
Adenylosuccinate mediates imeglimin-induced proliferative and anti-apoptotic actions in β-cells Inoue R et al Diabetes 2025
Imeglimin suppresses glucagon secretion and induces a loss of α-cell identity Tsuno T et al Cell Rep Med 2025
The matricellular protein Fibulin-5 regulates β-cell proliferation through autocrine/paracrine manner Okuyama T et al iScience 28:111856, 2025
E2F1 transcription factor mediates a link between fat and islets to promote β-cell proliferation in response to acute insulin resistance Shirakawa J et al Cell Rep 41:111436, 2022
Uncoupling protein 2 and aldolase B impact insulin release by modulating mitochondrial function and Ca2+ release from the ER Inoue R et al iScience 25:104603, 2022
Imeglimin ameliorates β-cell apoptosis by modulating the endoplasmic reticulum homeostasis pathway Li J et al Diabetes 71:424, 2021
Luseogliflozin increases beta cell proliferation through humoral factors that activate an insulin receptor- and IGF1 receptor-independent pathway Shirakawa J and Tajima K et al Diabetologia 63:577, 2020
Hitoshi Okochi (National Center for Global Health and Medicine, Japan)
High glucose burden disrupts the glucose responsiveness of human pancreatic beta cells encapsulated in alginate fibers during long-term culture Yabe S et al Gene 2025
Encapsulated human islets in alginate fiber maintain long-term functionality Nishida J et al Endocr J 71:253, 2023
Robert Screaton (Sunnybrook Research Institute, Canada)
Slicing of the G-protein coupled receptor 3-salt inducible kinase 2 pathway in human β cell proliferation Iorio C et al Commun Biol 4:907, 2021
High-throughput functional genomics identifies regulators of primary human beta cell proliferation Robitaille K et al J Biol Chem 29:4614, 2016
Nika Danial (Dana-Farber Cancer Institute, USA)
Glucose metabolism and pyruvate carboxylase enhance glutathione synthesis and restrict oxidative stress in beta-cells Fu A et al Cell Rep 37:110037, 2021
Glucose-dependent partitioning of arginine to the urea cycle protects β-cells from inflammation Fu A et al Nat Metab 2:432, 2020
Xiaojuan Chen (Columbia University, USA)
Abnormal regulation of glucagon secretion by human islet alpha cells in the absence of beta cells Liu W et al EBioMedicine 50:306, 2019
Mark Ungrin (University of Calgary, Canada)
Bioengineered human pseudoislets form efficiently from donated tissue, compare favourably with native islets in vitro and restore normoglycemia in mice Yu Y et al Diabetologia 61:2016, 2018
Adrian Teo (Institute of Molecular and Cell Biology, Singapore)
HNF4A and HNF1A exhibit tissue specific target gene regulation in pancreatic beta cells and hepatocytes Ng NHL et al Nat Commun 15:4288, 2024
Metformin perturbs pancreatic differentiation from human embryonic stem cells Nguyen L et al Diabetes 70:1689, 2021
Multimodal imaging probe development for pancreatic beta-cells: from fluorescence to PET Kang NY et al J Am Chem Soc 142:3430, 2020
Human islet isolation and distribution efforts for clinical and basic research Ng NHJ et al OBM Transplantation 3:31, 2019
Single cell analyses of human islet cells reveal de-differentiation signatures Teo AKK et al Cell Death Discov 4:14, 2018
Francis Lynn (University of British Columbia, Canada)
Transcriptional coactivator MED15 is required for beta cell maturation Kadhim AZ et al Nat Commun 2024
Type2 diabetes susceptibility gene GRK5 regulates physiological pancreatic beta-cell proliferation via phosphorylation of HDAC5 Sasaki S et al iScience 26, 107311, 2023
Calcium-dependent transcriptional changes in human pancreatic islet cells reveal functional diversity in islet cell subtypes Yoon JS et al Diabetologia 2022 Retracted on August 04, 2023
Neuronal PAS domain protein 4 (NPAS4) suppression of oxygen sensing optimizes metabolism during excitation of neuroendocrine cells Sabatini PV and Speckmann T et al Cell Rep 22:163, 2018
Hirofumi Noguchi (University of the Ryukyus, Japan)
Induction of expandable tissue-specific progenitor cells from human pancreatic tissue through transient expression of defined factors Noguchi H et al Mol Ther Methods Clin Dev 13:243, 2019
Role of EGR1 on pancreatic endoderm differentiation Tsugata T et al Cell Med 10:2155179017733177, 2018
Potential factors for the differentiation of ES/iPS cells into insulin-producing cells Tsugata T et al Cell Med 7:83, 2015
Susumu Eguchi (Nagasaki University, Japan)
Analysis of expression status and relationship between senescence-related genes and pancreatic function-related genes in human islets of Langerhans from donors of various ages Imamura H et al In Vitro 38:2165, 2024
An engineered cell sheet composed of human islets and human fibroblast, bone marrow-derived mesenchymal stem cells, or adipose-derived mesenchymal stem cells: An in vitro comparison study Imamura H et al Islets 10:e1445948, 2018
Human fibroblast sheet promotes human pancreatic islet survival and function in vitro Matsushima H et al Cell Transplant 25:1525,2016
Atsushi Miyajima (University of Tokyo, Japan)
CD82 is a marker to isolate β cell precursors from human iPS cells and plays a role for the maturation of β cells Watanabe A et al Sci Rep 11:9530, 2021
Hideki Taniguchi / Takanori Takebe (Yokohama City University, Japan)
Self-condensation culture enables vascularization of tissue fragments for efficient therapeutic transplantation Takahashi Y et al Cell Rep 23:1620, 2018
Kazuo Ohashi (Tokyo Women's Medical University, Japan)
Quality of air-transported human islets for single islet cells preparations Yamashita S et al Cell Med 6:33, 2013
Klearchos Papas (University of Arizona, USA)
Human islet viability and function is maintained during high density shipment on silicone rubber membrane vessels Kitzmann JP et al Transplant Proc 46:1989, 2014
Ho-Wook Jun (University of Alabama, USA)
Encapsulation of human islets using a biomimetic self-assembled nanomatrix gel for protection against cellular inflammatory responses Hwang PTJ et al ACS Biomater Sci Eng 3:2110, 2017
Holger Russ (University of Colorado, USA)
ENTPD3 marks mature stem cell–derived β-Cells formed by self-aggregation in vitro Docherty FM et al Diabetes 70:2554, 2021
Craig Nunemaker (Ohio University, USA)
The capacity to secrete insulin is dose-dependent to extremely high glucose concentrations: a key role for adenylyl cyclase Gerber KM and Whitticar NB et al Metabolites 11:401, 2021
Michael Wheeler (University of Toronto, Canada)
Beta cell specific ZnT8 gene deficiency and resulting loss in zinc content significantly improve insulin secretion Piro A et al Mol Cell Endocrinol 594:112376, 2024
γ‐aminobutyric acid stimulates β‐cell proliferation through the mTORC1/p70S6K pathway, an effect amplified by Ly49, a novel γ‐aminobutyric acid type A receptor positive allosteric modulator Untereiner A et al Diabetes Obes Metab 22:2021, 2020
The magnesium transporter NIPAL1 is a pancreatic islet-expressed protein that conditionally impacts insulin secretion Manialawy et al J Biol Chem 295:9879, 2020
GABA promotes β-cell proliferation, but does not overcome impaired glucose homeostasis associated with diet-induced obesity Untereiner A et al FASEB J 33:3968, 2019
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Elevated medium chain-acylcarnitines are associated with gestational diabetes, and early progression to type-2 diabetes, and induce pancreatic β-Cell dysfunction Batchuluun B et al Diabetes 67:885, 2018
Synthesis and characterization of urofuranoic acids: in vivo metabolism of 2-(2-carboxyethyl)-4-methyl-5-propylfuran-3-carboxylic acid (CMPF) and effects on in vitro insulin secretion Nagy E et al J Med Chem 60:1860, 2017
A novel GLP-1 receptor interacting protein ATP6ap2 regulates insulin secretion in pancreatic beta cells Dai FF et al J Biol Chem 290:25045, 2016
An abbreviated protocol for in vitro generation of functional human embryonic stem cell-derived beta-like cells Massumi M et al PLoS One 11:e0164457, 2016
Rapid elevation in CMPF may act as a tipping point in diabetes development Liu Y and Prentice KJ et al Cell Rep 14:2889, 2016
Characterization of Zinc Influx Transporters (ZIPs) in Pancreatic Beta Cells: Roles in Regulating Cytosolic Zinc Homeostasis and Insulin Secretion Liu Y et al J Biol Chem 290:18757, 2015
The furan fatty acid metabolite CMPF Is elevated in diabetes and induces beta cell dysfunction Prentice KJ et al Cell Metab 19:653, 2014
UCP2 regulates the glucagon response to fasting and starvation Allister EM et al Diabetes 62:1623, 2013
Effects of high-fat diet feeding on Znt8-null mice: differences between beta-cell and global knockout of Znt8 Hardy AB et al Am J Physiol Endocrinol Metab 302:E1084, 2012
The functional and molecular characterisation of human embryonic stem cell-derived insulin-positive cells compared with adult pancreatic beta cells Basford CL et al Diabetologia 55:358, 2012
Beta-cell uncoupling protein 2 regulates reactive oxygen species production, which influences both insulin and glucagon secretion Robson-Doucette CA et al Diabetes 60:2710, 2011
The adult mouse and human pancreas contain rare multipotent stem cells that express insulin Smukler SR et al Cell Stem Cell 8:281, 2011
Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion Wijesekara N et al Diabetologia 53:1656, 2010
Ex vivo transcriptional profiling of human pancreatic islets following chronic exposure to monounsaturated fatty acids Bikopoulos G et al J Endocinol 196:455, 2009
Characterization of ERG K+ channels in alpha and beta cells of mouse and human islets Hardy AB et al J Biol Chem 284:30441, 2009
Andrew Stewart (Icahn School of Medicine at Mount Sinai, USA)
Disrupting the DREAM complex enables proliferation of adult human pancreatic beta cells Wang P et al J Clin Invest 32:e157086, 2022
GLP-1 receptor agonists synergize with DYRK1A inhibitors to potentiate functional human beta cell regeneration Ackeifi C and Wang P et al Sci Transl Med 12:eaaw9996, 2020
Combined inhibition of DYRK1A, SMAD, and trithorax pathways synergizes to induce robust replication in adult human beta cells Wang P and Karakose E et al Cell Metab 29:638, 2019
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Cell-based methods to identify inducers of human pancreatic beta-cell proliferation Ackeifi CA et al Phenotyping Screening: Methods and Protocols, Methods in Molecular Biology vol 1787, 2018
Insights into beta cell regeneration for diabetes via integration of molecular landscapes in human insulinomas Wang H et al Nat Commun 8:767, 2017
Augmented Stat5 signaling bypasses multiple impediments to lactogen-mediated proliferation in human beta cells Chen H et al Diabetes 64:3784, 2015
A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication Wang P et al Nat Med 21:383, 2015
A human pancreatic beta cell G1/S molecule cell cycle atlas Fiaschi-Taesch NM et al Diabetes 62:2450, 2013
Cytoplasmic-nuclear trafficking of G1/S cell cycle molecules and adult human beta cell replication: a revised model of human beta cell G1/S control Fiaschi-Taesch NM et al Diabetes 62:2460, 2013
Regulated and reversible induction of adult human β-cell replication Takane KK et al Diabetes 61:418, 2012
cMyc is a principal upstream driver of beta-cell proliferation in rat insulinoma cell lines and is an effective mediator of human beta-cell replication Karslioglu E et al Mol Endocrinol 25:1760, 2011
Yuval Dor (Hebrew University of Jerusalem, Israel)
DNA methylation-based assessment of cell composition in human pancreas and islets Drawshy Z et al Diabetes 73:554, 2024
A DNA methylation atlas of normal human cell types Loyfer N et al Nature 613:355, 2023
Islet cells share promoter hypomethylation independently of expression, but exhibit cell-type-specific methylation in enhancers Neiman D and Moss J et al Proc Natl Acad Sci USA 114:13525, 2017
p16Ink4a-induced senescence of pancreatic beta cells enhances insulin secretion Helman A et al Nat Med 22:412, 2016
Recognition and killing of human and murine pancreatic beta cells by the NK receptor NKp46 Gur C et al J Immunol 187:3096, 2011
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Glucose regulates cyclin D2 expression in quiescent and replicating pancreatic β-cells through glycolysis and calcium channels Salpeter SJ et al Endocrinology 152:2589, 2011
Vincent Poitout (University of Montreal, Canada)
Beta-cell mass expansion during puberty involves serotonin signaling and determines glucose homeostasis in adulthood Castell A-L et al JCI Insight 7:e160854, 2022
Pronounced proliferation of non-beta cells in response to beta-cell mitogens in isolated human islets of Langerhans Maachi H et al Sci Rep 11:11283, 2021
Glucose and fatty acids synergistically and reversibly promote beta cell proliferation in rats Moullé VS et al Diabetologia 60:879, 2017
The regulator of G-protein signaling RGS16 promotes insulin secretion and β-cell proliferation in rodent and human islets Vivot K et al Mol Metab 5:988, 2016
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Epidermal growth factor receptor signaling promotes pancreatic β-cell proliferation in response to nutrient excess in rats through mTOR and FOXM1 Zarrouki B et al Diabetes 63:982, 2014
Glucose activates free fatty acid receptor 1 gene transcription via phosphatidylinositol-3-kinase-dependent O-GlcNAcylation of pancreas-duodenum homeobox-1 Kebede M et al Proc Natl Acad Sci USA 109:2376, 2012
Lipopolysaccharides impair insulin gene expression in isolated islets of Langerhans via toll-like receptor-4 and NF-κB signalling Amyot J et al PLoS One 7:e36200, 2012
Discovery of novel glucose-regulated proteins in isolated human pancreatic islets using LC-MS/MS-based proteomics Schrimpe-Rutledge AC et al J Proteome Res 11:3520, 2012
Guy Rutter (Imperial College London, UK)
Glucose-dependent miR-125b is a negative regulator of β-cell function Cheung R and Pizza G et al Diabetes 71: 1525, 2022
Leader β-cells coordinate Ca2+ dynamics across pancreatic islets in vivo Salem V et al Nature Metab 1:615, 2019
The effects of kisspeptin on β-cell function, serum metabolites and appetite in humans Izzi-Engbeaya C and Comninos AN et al Diabetes Obes Metab 20:2800, 2018
Targeting GLP-1 receptor trafficking to improve agonist efficacy Jones B et al Nat Commun 9:1602, 2018
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A targeted RNAi screen identifies endocytic trafficking factors that control GLP-1 receptor signaling in pancreatic beta cells Buenaventura T et al Diabetes 67:385, 2018
MiR-184 expression is regulated by AMPK in pancreatic islets Martinez-Sanchez A et al FASEB J 32:2587, 2018
Sorcin links pancreatic β cell lipotoxicity to ER Ca2+ stores Marmugi A et al Diabetes 65:1009, 2016
ADCY5 couples glucose to insulin secretion in human islets Hodson DJ et al Diabetes 63:3009, 2014
Optical control of insulin release using a photoswitchable sulfonylurea Broichhagen J et al Nat Commun 5:5116, 2014
Fred Levine (Burnham Institute for Medical Research, USA)
Id3 upregulates BrdU incorporation associated with a DNA damage response, not replication, inhuman pancreatic β-cells Lee SH et al Islets 3:358, 2011
The Id3/E47 axis mediates cell-cycle control in human pancreatic ducts and adenocarcinoma Lee SH et al Mol Cancer Res 9:782, 2011
CENP-A, a protein required for chromosome segregation in mitosis, declines with age in islet but not exocrine cells Lee S-H et al Aging 2:785, 2010
James Shaw (Newcastle University, UK)
Exendin-4 stimulates autophagy in pancreatic β-cells via the RAPGEF/EPAC-Ca2+-PPP3/calcineurin-TFEB axis Zummo FP et al Autophagy DOI: 10.1080/15548627.2021.1956123
Glucagon-like peptide 1 protects pancreatic β-cells from death by increasing autophagic flux and restoring lysosomal function Zummo FP et al Diabetes 66:1272, 2017
Sigal Shaklai (Tel Aviv Sourasky Medical Center, Israel)
Estradiol 17-β induces pancreatic beta-cell proliferation through distinct estrogen receptors in a glucose dependent manner Shaklai S et al OBM Transplantation 3:11, 2019
Pancreatic beta-cell proliferation induced by estradiol-17β is Foxo1 dependent Shaklai S and Grafi-Cohen M et al Horm Metab Res 50: 485, 2018
Shimon Efrat (Tel Aviv University, Israel)
Redifferentiation of expanded human islet β cells by inhibition of ARX Friedman-Mazursjy O et al Sci Rep 6:20698, 2016
Pamela Itkin-Ansari (University of California San Diego, USA)
The IRE1α/XBP1s pathway is essential for the glucose response and protection of β cells Hassler JR et al PLoS Biol 13:e1002277, 2015
Eduardo Mitrani (Hebrew University of Jerusalem, Israel)
Lung-derived microscaffolds facilitate diabetes reversal after mouse and human intraperitoneal islet transplantation Abualhassan N et al PLoS One 1:e0156053, 2016
[Coming soon]
Rebeca Hull-Meichle (University of Alberta, Canada)
Sasanka Ramanadham (University of Alabama, USA)
Heiko Lickert (German Center for Diabetes Research, Germany)
Accalia Fu (UMass Chan Medical School, USA)
Shoen Kume (Tokyo Institute of Technology, Japan)
Yasuhiro Yamada (University of Tokyo, Japan)
[Previous users with no publication yet]
Alex Rabinovitch (University of Alberta, Canada)
Ron Gill (University of Alberta, Canada)
Jean Buteau (University of Alberta, Canada)
Dawei Zhang (University of Alberta, Canada)
Ben Willing (University of Alberta, Canada)
Eba Hathout (Loma Linda University Children's Hospital, USA)
Delfina Siroen (Senova Corp, Canada)
Hongjun Wang (Medical University of South Carolina, USA)
G. Ian Gallicano (Medstar Georgetown Transplant Institute, USA)
Per-Olof Berggren (Nanyang Technological University, Singapore)
Yuichi Masuda (Shinshu University, Japan)
Geroge Harb (Semma Therapeutics, USA)
Andras Nagy (Lunenfeld-Tanenbaum Research Institute, Canada)
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