2016 (18 papers)
A novel GLP-1 receptor interacting protein ATP6ap2 regulates insulin secretion in pancreatic beta cells Dai FF et al J Biol Chem 290:25045, 2016
Long-term function and optimization of mouse and human islet transplantation in the subcutaneous device-less site Pepper A et al Islets 8:186, 2016
An abbreviated protocol for in vitro generation of functional human embryonic stem cell-derived beta-like cells Massumi M et al PLoSOne 11:e0164457, 2016
The regulator of G-protein signaling RGS16 promotes insulin secretion and β-cell proliferation in rodent and human islets Vivot K et al Mol Metab 5:988, 2016
A novel pre-vascularized subcutaneous site safely accommodates stem cell derived therapies for treating diabetes Gala-Lopez B et al J Stem Trans Biol 2:270000107, 2016
Lung-derived microscaffolds facilitate diabetes reversal after mouse and human intraperitoneal islet transplantation Abualhassan N et al PLoS One 11:e0156053, 2016
PI3 kinases p110α and PI3K-C2β negatively regulate cAMP via PDE3/8 to control insulin secretion in mouse and human islets Kolic J et al Mol Metab 5:459, 2016
A glycine-insulin autocrine feedback loop enhances insulin secretion from human β-cells and is impaired in type 2 diabetes Yan-Do R et al Diabetes 65:2311, 2016
Interleukin-1 signaling contributes to acute islet compensation Hajmrle C et al JCI Insight 1:e86055, 2016
Rapid elevation in CMPF may act as a tipping point in diabetes development Liu Y and Prentice KJ et al Cell Rep 14:2889, 2016
Redifferentiation of expanded human islet β cells by inhibition of ARX Friedman-Mazursjy O et al Sci Rep 6:20698, 2016
p16Ink4a-induced senescence of pancreatic beta cells enhances insulin secretion Helman A et al Nat Med 22:412, 2016
Sorcin links pancreatic β cell lipotoxicity to ER Ca2+ stores Marmugi A et al Diabetes 65:1009, 2016
Human fibroblast sheet promotes human pancreatic islet survival and function in vitro Matsushima H et al Cell Transplant 25:1525, 2016
High-throughput functional genomics identifies regulators of primary human beta cell proliferation Robitaille K et al J Biol Chem 29:4614, 2016
TCF1 links GIPR signaling to the control of beta cell function and survival Campbell JE et al Nat Med 22:84, 2016
Anti-aging glycopeptide protects human islets against tacrolimus-related injury and facilitates engraftment in mice Gala-Lopez BL et al Diabetes 65:451, 2016
Research-focused isolation of human islets from donors with and without diabetes at the Alberta Diabetes Institute IsletCore Lyon J et al Endocrinology 157:560, 2016