Publications - year -

2025

• Adenylosuccinate mediates imeglimin-induced proliferative and anti-apoptotic actions in β-cells  Inoue R et al  Diabetes 2025

• High glucose burden disrupts the glucose responsiveness of human pancreatic beta cells encapsulated in alginate fibers during long-term culture  Yabe S et al  Gene 2025

• Molecular correlates of glycine receptor activity in human β cells  Gomes AS et al  Mol Metab 2025  

• Imeglimin suppresses glucagon secretion and induces a loss of α-cell identity  Tsuno T et al  Cell Rep Med 2025

• TMEM55A-mediated PI5P signaling regulates α-cell actin depolymerization and glucagon secretion  Liu X et al  Diabtologia 2025

• The matricellular protein Fibulin-5 regulates β-cell proliferation through autocrine/paracrine manner  Okuyama T et al  iScience 28:111856, 2025

2024

• Analysis of expression status and relationship between senescence-related genes and pancreatic function-related genes in human islets of Langerhans from donors of various ages  Imamura H et al  In Vitro 38:2165, 2024 

• Beta cell specific ZnT8 gene deficiency and resulting loss in zinc content significantly improve insulin secretion  Piro A et al  Mol Cell Endocrinol 594:112376, 2024

• Transcriptional coactivator MED15 is required for beta cell maturation  Kadhim AZ et al  Nat Commun 15: 8711, 2024

• HNF4A and HNF1A exhibit tissue specific target gene regulation in pancreatic beta cells and hepatocytes Ng NHL et al  Nat Commun 15:4288, 2024

• DNA methylation-based assessment of cell composition in human pancreas and islets  Drawshy Z et al  Diabetes 73:554, 2024

• Encapsulated human islets in alginate fiber maintain long-term functionality  Nishida J et al  Endocr J 71:253, 2024

2023

• A DNA methylation atlas of normal human cell types  Loyfer N et al  Nature 613:355, 2023

• Type2 diabetes susceptibility gene GRK5 regulates physiological pancreatic beta-cell proliferation via phosphorylation of HDAC5  Sasaki S et al iScience 26:107311, 2013

• Nanothin onformal coating with poly(N-vinylpyrrolidone) and tannic acid (PVPON/TA) preserves murine and human pancreatic islets function Polishevska K et al  Pharmaceutics 15:1137, 2023

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