ESR 1 - University of Sheffield

Congratulations to Kenji Kopf!

Project: A Ni-Catalysed Benzannulation to N-Heteroaromatic Boronates

USFD are seeking to appoint an ESR (Early Stage Researcher)/PhD for 42 months to i) explore the scope of alkynylboronate cycloadditions with isatoic anhydrides and phthalimides; ii) establish empirical selectivity data relating to the regiochemical insertion of the alkynes in these reactions (regio-chemistry and -selectivity); iii) demonstrate that the products can be exploited in further catalytic cross-coupling processes. The ESR will demonstrate the employment of novel MOF-based Pd catalysts for the cross-coupling of heteroaromatic boronates prepared in this project as part of their Joint Degree Secondment at SU. A further 3-month Industrial Secondment at AstraZeneca will allow the ESR to demonstrate that heteroaromatic boronates prepared here can undergo Suzuki coupling using supported Pd-catalysts under batch and flow regimes to generate novel heterocycle arrays.

Informal Enquiries may be sent to Prof Joseph Harrity

For further information and application details click here