Publications

http://scholar.google.com/citations?hl=en&user=h8pxrSEAAAAJ
  1. Wood CR, Squire MS, Finley NL, Page RC, Actis LA. Structural and functional analysis of the Acinetobacter baumannii BlsA photoreceptor and regulatory protein. PLoS One. 2019;14(8):e0220918. doi: 10.1371/journal.pone.0220918. eCollection 2019. PubMed PMID: 31415622; PubMed Central PMCID: PMC6695109.
  2. Moseng MA, Nix JC, Page RC. 2- and N6-functionalized adenosine-5'-diphosphate analogs for the inhibition of mortalin. FEBS Lett. 2019 Aug;593(15):2030-2039. doi: 10.1002/1873-3468.13475. Epub 2019 Jun 18. PubMed PMID: 31177526; PubMed Central PMCID: PMC6690775.
  3. Shurina BA, Page RC. Influence of substrates and inhibitors on the structure of Klebsiella pneumoniae carbapenemase-2. Exp Biol Med (Maywood). 2019 Jun 4;:1535370219854322. doi: 10.1177/1535370219854322. [Epub ahead of print] PubMed PMID: 31161945.
  4. Moseng MA, Nix JC, Page RC. Biophysical Consequences of EVEN-PLUS Syndrome Mutations for the Function of Mortalin. J Phys Chem B. 2019 Apr 25;123(16):3383-3396. doi: 10.1021/acs.jpcb.9b00071. Epub 2019 Apr 12. PubMed PMID: 30933555; PubMed Central PMCID: PMC6483861.
  5. VanPelt J, Shurina BA, Ramelot TA, Bonomo RA, Page RC. 1H, 13C, and 15N backbone resonance assignments for KPC-2, a class A serine-β-lactamase. Biomol NMR Assign. 2019 Apr;13(1):139-142. doi: 10.1007/s12104-018-9866-8. Epub 2018 Dec 14. PubMed PMID: 30552637; PubMed Central PMCID: PMC6440833.
  6. Wright TA, Page RC, Konkolewicz D. Polymer conjugation of proteins as a synthetic post-translational modification to impact their stability and activity. Polym Chem. 2019 Jan 28;10(4):434-454. doi: 10.1039/C8PY01399C. Epub 2018 Dec 7. PubMed PMID: 31249635; PubMed Central PMCID: PMC6596429.
  7. Emery P, Yezierski EJ, Page RC. Guided inquiry activity linking thermodynamic parameters of protein unfolding to structure using differential scanning fluorimetry data in the biophysical chemistry classroom. Biochem Mol Biol Educ. 2019 Jan;47(1):67-75. doi: 10.1002/bmb.21198. Epub 2018 Dec 22. PubMed PMID: 30578703; PubMed Central PMCID: PMC6329392.
  8. Shi CH, Rubel C, Soss SE, Sanchez-Hodge R, Zhang S, Madrigal SC, Ravi S, McDonough H, Page RC, Chazin WJ, Patterson C, Mao CY, Willis MS, Luo HY, Li YS, Stevens DA, Tang MB, Du P, Wang YH, Hu ZW, Xu YM, Schisler JC. Disrupted structure and aberrant function of CHIP mediates the loss of motor and cognitive function in preclinical models of SCAR16. PLoS Genet. 2018 Sep;14(9):e1007664. doi: 10.1371/journal.pgen.1007664. eCollection 2018 Sep. PubMed PMID: 30222779; PubMed Central PMCID: PMC6160236.
  9. Cheng Z, VanPelt J, Bergstrom A, Bethel C, Katko A, Miller C, Mason K, Cumming E, Zhang H, Kimble RL, Fullington S, Bretz SL, Nix JC, Bonomo RA, Tierney DL, Page RC, Crowder MW. A Noncanonical Metal Center Drives the Activity of the Sediminispirochaeta smaragdinae Metallo-β-lactamase SPS-1. Biochemistry. 2018 Sep 4;57(35):5218-5229. doi: 10.1021/acs.biochem.8b00728. Epub 2018 Aug 21. PubMed PMID: 30106565; PubMed Central PMCID: PMC6314204.
  10. Cheng Z, Thomas PW, Ju L, Bergstrom A, Mason K, Clayton D, Miller C, Bethel CR, VanPelt J, Tierney DL, Page RC, Bonomo RA, Fast W, Crowder MW. Evolution of New Delhi metallo-β-lactamase (NDM) in the clinic: Effects of NDM mutations on stability, zinc affinity, and mono-zinc activity. J Biol Chem. 2018 Aug 10;293(32):12606-12618. doi: 10.1074/jbc.RA118.003835. Epub 2018 Jun 16. PubMed PMID: 29909397; PubMed Central PMCID: PMC6093243.
  11. Kovaliov M, Cohen-Karni D, Burridge KA, Mambelli D, Sloane S, Daman N, Xu C, Guth J, Wickiser J, Tomycz N, Page RC, Konkolewicz D, Averick S. Grafting strategies for the synthesis of active DNase I polymer biohybrids. European polymer journal. 2018 July; 107:15-24. doi: 10.1016/j.eurpolymj.2018.07.041.
  12. Danielson AP, Bailey Van-Kuren D, Bornstein JP, Kozuszek CT, Berberich JA, Page RC, Konkolewicz D. Investigating the Mechanism of Horseradish Peroxidase as a RAFT-Initiase. Polymers. 2018 July; 10(7):741. doi: 10.3390/polym10070741.
  13. Burridge KM, Wright TA, Page RC, Konkolewicz D. Photochemistry for Well-Defined Polymers in Aqueous Media: From Fundamentals to Polymer Nanoparticles to Bioconjugates. Macromol Rapid Commun. 2018 Jun;39(12):e1800093. doi: 10.1002/marc.201800093. Epub 2018 May 17. Review. PubMed PMID: 29774614.
  14. Bergstrom A, Katko A, Adkins Z, Hill J, Cheng Z, Burnett M, Yang H, Aitha M, Mehaffey MR, Brodbelt JS, Tehrani KHME, Martin NI, Bonomo RA, Page RC, Tierney DL, Fast W, Wright GD, Crowder MW. Probing the Interaction of Aspergillomarasmine A with Metallo-β-lactamases NDM-1, VIM-2, and IMP-7. ACS Infect Dis. 2018 Feb 9;4(2):135-145. doi: 10.1021/acsinfecdis.7b00106. Epub 2017 Nov 9. PubMed PMID: 29091730; PubMed Central PMCID: PMC5807211.
  15. Stewart AC, Bethel CR, VanPelt J, Bergstrom A, Cheng Z, Miller CG, Williams C, Poth R, Morris M, Lahey O, Nix JC, Tierney DL, Page RC, Crowder MW, Bonomo RA, Fast W. Clinical Variants of New Delhi Metallo-β-Lactamase Are Evolving To Overcome Zinc Scarcity. ACS Infect Dis. 2017 Dec 8;3(12):927-940. doi: 10.1021/acsinfecdis.7b00128. Epub 2017 Oct 11. PubMed PMID: 28965402; PubMed Central PMCID: PMC5726261.
  16. Roche Allred ZD, Tai H, Bretz SL, Page RC. Using PyMOL to Explore the Effects of pH on Noncovalent Interactions between Immunoglobulin G and Protein A: A Guided-Inquiry Biochemistry Activity. Biochem Mol Biol Educ. 2017 Nov;45(6):528-536. doi: 10.1002/bmb.21066. Epub 2017 May 24. PubMed PMID: 28544448.
  17. Wright TA, Lucius Dougherty M, Schmitz B, Burridge KM, Makaroff K, Stewart JM, Fischesser HD, Shepherd JT, Berberich JA, Konkolewicz D, Page RC. Polymer Conjugation to Enhance Cellulase Activity and Preserve Thermal and Functional Stability. Bioconjug Chem. 2017 Oct 18;28(10):2638-2645. doi: 10.1021/acs.bioconjchem.7b00518. Epub 2017 Oct 5. PubMed PMID: 28934551.
  18. Chen AY, Thomas PW, Stewart AC, Bergstrom A, Cheng Z, Miller C, Bethel CR, Marshall SH, Credille CV, Riley CL, Page RC, Bonomo RA, Crowder MW, Tierney DL, Fast W, Cohen SM. Dipicolinic Acid Derivatives as Inhibitors of New Delhi Metallo-β-lactamase-1. J Med Chem. 2017 Sep 14;60(17):7267-7283. doi: 10.1021/acs.jmedchem.7b00407. Epub 2017 Aug 30. PubMed PMID: 28809565; PubMed Central PMCID: PMC5599375.
  19. Zhang H, McGlone C, Mannion MM, Page RC. 1H, 15N and 13C resonance assignments for free and IEEVD peptide-bound forms of the tetratricopeptide repeat domain from the human E3 ubiquitin ligase CHIP. Biomol NMR Assign. 2017 Apr;11(1):5-9. doi: 10.1007/s12104-016-9710-y. Epub 2016 Oct 5. PubMed PMID: 27709416; PubMed Central PMCID: PMC5343084.
  20. Wright TA, Stewart JM, Page RC, Konkolewicz D. Extraction of Thermodynamic Parameters of Protein Unfolding Using Parallelized Differential Scanning Fluorimetry. J Phys Chem Lett. 2017 Feb 2;8(3):553-558. doi: 10.1021/acs.jpclett.6b02894. Epub 2017 Jan 12. PubMed PMID: 28067526.
  21. VanPelt J, Page RC. Unraveling the CHIP:Hsp70 complex as an information processor for protein quality control. Biochim Biophys Acta Proteins Proteom. 2017 Feb;1865(2):133-141. doi: 10.1016/j.bbapap.2016.11.005. Epub 2016 Nov 15. Review. PubMed PMID: 27863257.
  22. Williams C, Dougherty ML, Makaroff K, Stapleton J, Konkolewicz D, Berberich JA, Page RC. Strategies for Biophysical Characterization of Protein-Polymer Conjugates. Methods Enzymol. 2017;590:93-114. doi: 10.1016/bs.mie.2016.11.008. Epub 2017 Jan 10. PubMed PMID: 28411652.
  23. Paeth M, Stapleton J, Dougherty ML, Fischesser H, Shepherd J, McCauley M, Falatach R, Page RC, Berberich JA, Konkolewicz D. Approaches for Conjugating Tailor-Made Polymers to Proteins. Methods Enzymol. 2017;590:193-224. doi: 10.1016/bs.mie.2016.12.004. Epub 2017 Jan 10. PubMed PMID: 28411638.
  24. Meng F, Yang H, Jack C, Zhang H, Moller A, Spivey D, Page RC, Tierney DL, Crowder MW. Biochemical characterization and zinc binding group (ZBGs) inhibition studies on the catalytic domain of MMP7 (cdMMP7). J Inorg Biochem. 2016 Dec;165:7-17. doi: 10.1016/j.jinorgbio.2016.10.005. Epub 2016 Oct 14. PubMed PMID: 27755977.
  25. Lucius M, Falatach R, McGlone C, Makaroff K, Danielson A, Williams C, Nix JC, Konkolewicz D, Page RC, Berberich JA. Investigating the Impact of Polymer Functional Groups on the Stability and Activity of Lysozyme-Polymer Conjugates. Biomacromolecules. 2016 Mar 14;17(3):1123-34. doi: 10.1021/acs.biomac.5b01743. Epub 2016 Feb 26. PubMed PMID: 26866284.
  26. Danielson AP, Bailey-Van Kuren D, Lucius ME, Makaroff K, Williams C, Page RC, Berberich JA, Konkolewicz D. Well-Defined Macromolecules Using Horseradish Peroxidase as a RAFT Initiase. Macromol Rapid Commun. 2016 Feb;37(4):362-7. doi: 10.1002/marc.201500633. Epub 2016 Jan 8. PubMed PMID: 26748786.
  27. Falatach R, Li S, Sloane S, McGlone C, Berberich JA, Page RC, Averick S, Konkolewicz D. Why synthesize protein–polymer conjugates? The stability and activity of chymotrypsin-polymer bioconjugates synthesized by RAFT. Polymer. 2015 August; 72:382-386. doi: 10.1016/j.polymer.2015.04.010.
  28. Hannibal L, Page RC, Haque MM, Bolisetty K, Yu Z, Misra S, Stuehr DJ. Dissecting structural and electronic effects in inducible nitric oxide synthase. Biochem J. 2015 Apr 1;467(1):153-65. doi: 10.1042/BJ20141319. PubMed PMID: 25608846; PubMed Central PMCID: PMC4369157.
  29. Falatach R, McGlone C, Al-Abdul-Wahid MS, Averick S, Page RC, Berberich JA, Konkolewicz D. The best of both worlds: active enzymes by grafting-to followed by grafting-from a protein. Chem Commun (Camb). 2015 Mar 28;51(25):5343-6. doi: 10.1039/c4cc09287b. PubMed PMID: 25530198.
  30. Daka P, Liu A, Karunaratne C, Csatary E, Williams C, Xiao H, Lin J, Xu Z, Page RC, Wang H. Design, synthesis and evaluation of XZH-5 analogues as STAT3 inhibitors. Bioorg Med Chem. 2015 Mar 15;23(6):1348-55. doi: 10.1016/j.bmc.2015.01.025. Epub 2015 Jan 22. PubMed PMID: 25698618.
  31. Zhang H, Amick J, Chakravarti R, Santarriaga S, Schlanger S, McGlone C, Dare M, Nix JC, Scaglione KM, Stuehr DJ, Misra S, Page RC. A bipartite interaction between Hsp70 and CHIP regulates ubiquitination of chaperoned client proteins. Structure. 2015 Mar 3;23(3):472-482. doi: 10.1016/j.str.2015.01.003. Epub 2015 Feb 12. PubMed PMID: 25684577; PubMed Central PMCID: PMC4351142.
  32. Aitha M, Marts AR, Bergstrom A, Møller AJ, Moritz L, Turner L, Nix JC, Bonomo RA, Page RC, Tierney DL, Crowder MW. Biochemical, mechanistic, and spectroscopic characterization of metallo-β-lactamase VIM-2. Biochemistry. 2014 Nov 25;53(46):7321-31. doi: 10.1021/bi500916y. Epub 2014 Nov 13. PubMed PMID: 25356958; PubMed Central PMCID: PMC4245990.
  33. Amick J, Schlanger SE, Wachnowsky C, Moseng MA, Emerson CC, Dare M, Luo WI, Ithychanda SS, Nix JC, Cowan JA, Page RC, Misra S. Crystal structure of the nucleotide-binding domain of mortalin, the mitochondrial Hsp70 chaperone. Protein Sci. 2014 Jun;23(6):833-42. doi: 10.1002/pro.2466. Epub 2014 Apr 17. PubMed PMID: 24687350; PubMed Central PMCID: PMC4093958.
  34. Zheng C, Page RC, Das V, Nix JC, Wigren E, Misra S, Zhang B. Structural characterization of carbohydrate binding by LMAN1 protein provides new insight into the endoplasmic reticulum export of factors V (FV) and VIII (FVIII). J Biol Chem. 2013 Jul 12;288(28):20499-509. doi: 10.1074/jbc.M113.461434. Epub 2013 May 24. PubMed PMID: 23709226; PubMed Central PMCID: PMC3711315.
  35. Smith L, Litman P, Kohli E, Amick J, Page RC, Misra S, Liedtke CM. RACK1 interacts with filamin-A to regulate plasma membrane levels of the cystic fibrosis transmembrane conductance regulator. Am J Physiol Cell Physiol. 2013 Jul 1;305(1):C111-20. doi: 10.1152/ajpcell.00026.2013. Epub 2013 May 1. PubMed PMID: 23636454; PubMed Central PMCID: PMC3725521.
  36. Klenotic PA, Page RC, Li W, Amick J, Misra S, Silverstein RL. Molecular basis of antiangiogenic thrombospondin-1 type 1 repeat domain interactions with CD36. Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1655-62. doi: 10.1161/ATVBAHA.113.301523. Epub 2013 May 2. PubMed PMID: 23640500; PubMed Central PMCID: PMC3737738.
  37. Page RC, Xu Z, Amick J, Nix JC, Misra S. Crystallization and preliminary X-ray crystallographic analysis of the Bag2 amino-terminal domain from Mus musculus. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Jun 1;68(Pt 6):647-51. doi: 10.1107/S1744309112013267. Epub 2012 May 23. PubMed PMID: 22684061; PubMed Central PMCID: PMC3370901.
  38. Page RC, Pruneda JN, Amick J, Klevit RE, Misra S. Structural insights into the conformation and oligomerization of E2~ubiquitin conjugates. Biochemistry. 2012 May 22;51(20):4175-87. doi: 10.1021/bi300058m. Epub 2012 May 14. PubMed PMID: 22551455; PubMed Central PMCID: PMC3366460.
  39. Klenotic PA, Page RC, Misra S, Silverstein RL. Expression, purification and structural characterization of functionally replete thrombospondin-1 type 1 repeats in a bacterial expression system. Protein Expr Purif. 2011 Dec;80(2):253-9. doi: 10.1016/j.pep.2011.07.010. Epub 2011 Jul 29. PubMed PMID: 21821127; PubMed Central PMCID: PMC3195888.
  40. Bulek K, Liu C, Swaidani S, Wang L, Page RC, Gulen MF, Herjan T, Abbadi A, Qian W, Sun D, Lauer M, Hascall V, Misra S, Chance MR, Aronica M, Hamilton T, Li X. The inducible kinase IKKi is required for IL-17-dependent signaling associated with neutrophilia and pulmonary inflammation. Nat Immunol. 2011 Aug 7;12(9):844-52. doi: 10.1038/ni.2080. PubMed PMID: 21822257; PubMed Central PMCID: PMC3282992.
  41. Page RC, Clark JG, Misra S. Structure of filamin A immunoglobulin-like repeat 10 from Homo sapiens. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Aug 1;67(Pt 8):871-6. doi: 10.1107/S1744309111024249. Epub 2011 Jul 26. PubMed PMID: 21821884; PubMed Central PMCID: PMC3151117.
  42. Smith L, Page RC, Xu Z, Kohli E, Litman P, Nix JC, Ithychanda SS, Liu J, Qin J, Misra S, Liedtke CM. Biochemical basis of the interaction between cystic fibrosis transmembrane conductance regulator and immunoglobulin-like repeats of filamin. J Biol Chem. 2010 May 28;285(22):17166-76. doi: 10.1074/jbc.M109.080911. Epub 2010 Mar 29. PubMed PMID: 20351101; PubMed Central PMCID: PMC2878048.
  43. Yang J, Ma YQ, Page RC, Misra S, Plow EF, Qin J. Structure of an integrin alphaIIb beta3 transmembrane-cytoplasmic heterocomplex provides insight into integrin activation. Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17729-34. doi: 10.1073/pnas.0909589106. Epub 2009 Oct 1. PubMed PMID: 19805198; PubMed Central PMCID: PMC2764936.
  44. Page RC, Lee S, Moore JD, Opella SJ, Cross TA. Backbone structure of a small helical integral membrane protein: A unique structural characterization. Protein Sci. 2009 Jan;18(1):134-46. doi: 10.1002/pro.24. PubMed PMID: 19177358; PubMed Central PMCID: PMC2708045.
  45. Xu Z, Page RC, Gomes MM, Kohli E, Nix JC, Herr AB, Patterson C, Misra S. Structural basis of nucleotide exchange and client binding by the Hsp70 cochaperone Bag2. Nat Struct Mol Biol. 2008 Dec;15(12):1309-17. doi: 10.1038/nsmb.1518. Epub 2008 Nov 23. PubMed PMID: 19029896; PubMed Central PMCID: PMC2680549.
  46. Tejero J, Biswas A, Wang ZQ, Page RC, Haque MM, Hemann C, Zweier JL, Misra S, Stuehr DJ. Stabilization and characterization of a heme-oxy reaction intermediate in inducible nitric-oxide synthase. J Biol Chem. 2008 Nov 28;283(48):33498-507. doi: 10.1074/jbc.M806122200. Epub 2008 Sep 24. PubMed PMID: 18815130; PubMed Central PMCID: PMC2586280.
  47. Page RC, Kim S, Cross TA. Transmembrane helix uniformity examined by spectral mapping of torsion angles. Structure. 2008 May;16(5):787-97. doi: 10.1016/j.str.2008.02.018. PubMed PMID: 18462683; PubMed Central PMCID: PMC2435096.
  48. Page RC, Li C, Hu J, Gao FP, Cross TA. Lipid bilayers: an essential environment for the understanding of membrane proteins. Magn Reson Chem. 2007 Dec;45 Suppl 1:S2-11. doi: 10.1002/mrc.2077. Epub 2007 Dec 19. Review. PubMed PMID: 18095258.
  49. Page RC, Moore JD, Nguyen HB, Sharma M, Chase R, Gao FP, Mobley CK, Sanders CR, Ma L, Sönnichsen FD, Lee S, Howell SC, Opella SJ, Cross TA. Comprehensive evaluation of solution nuclear magnetic resonance spectroscopy sample preparation for helical integral membrane proteins. J Struct Funct Genomics. 2006 Mar;7(1):51-64. doi: 10.1007/s10969-006-9009-9. Epub 2006 Jul 19. Review. PubMed PMID: 16850177.