Greg J. Hermann
PRESENT ADDRESS:
Department of Biology
Lewis and Clark College
615 S. Palatine Hill Rd.
Portland, Oregon 97219-7899
phone: (503) 768-7568
e-mail: hermann@lclark.edu
EDUCATION:
1998 Ph.D., Biology
University of Utah
Salt Lake City, Utah
1992 B.S., Biology, Magna Cum Laude
Gonzaga University
Spokane, Washington
PROFESSIONAL EXPERIENCE:
2013-present Professor
Department of Biology
Lewis and Clark College
Portland, Oregon
2016-2017, 2012-2014 Chair of Biology
Lewis & Clark College
Portland, OR
2010-2012 Director of Molecular Biology and Biochemistry Program
Lewis and Clark College
Portland, Oregon
2007-2013 Associate Professor
Department of Biology
Lewis and Clark College
Portland, Oregon
2001-2007 Assistant Professor
Department of Biology
Lewis and Clark College
Portland, Oregon
1998-2001 Postdoctoral research with Dr. James Priess
"Organogenesis of the Caenorhabditis elegans Intestine"
Division of Basic Sciences
Fred Hutchinson Cancer Research Center and Howard Hughes Medical Institute
Seattle, Washington
1993-1998 Graduate research with Dr. Janet Shaw
"Genetic Analysis of Mitochondrial Inheritance and Morphology in Yeast"
Department of Biology
University of Utah
Salt Lake City, Utah
1991-1992 Undergraduate research with Dr. Peter Pauw
"Role of the Na+-K+ ATPase During Muscle Development"
Department of Biology
Gonzaga University
Spokane, Washington
GRANTS/AWARDS:
2024-2027 National Institutes of Health
"R15-AREA: Investigating the role of lipid metabolism in the biogenesis of lysosome-related organelles"
2021-2025 National Science Foundation
“RUI: Investigating the pathways and regulation of lysosome-related organelle biogenesis”
2021-2024 co-PI National Science Foundation
"MRI: Acquisition of a benchtop cell sorter to advance undergraduate research and training in biology at Lewis & Clark College"
2016-2021 National Institutes of Health
“R15-AREA: Rab activation by ABC proteins during lysosome-related organelle biogenesis”
2016-2021 National Science Foundation
"RUI: Investigating the mechanisms regulating the formation of lysosome-related organelles"
2014 HOPES Award from American Society for Biochemistry & Molecular Biology
"Implementing an active learning module using RNAi in C. elegans" in collaboration with Amy Lindahl at Grant High School
2013-2016 co-PI National Science Foundation
“MRI: Acquisition of a laser scanning confocal microscope to advance research and training in biology, chemistry, and physics at Lewis & Clark College”
2012 Council on Undergraduate Research: Outstanding Biology Mentor Award
2011-2015 National Science Foundation
"RUI: Investigating the mechanism of GLO-1 Rab function in C. elegans lysosome-related organelle biogenesis"
2009-2012 National Science Foundation
"MRI: Acquisition of a fluorescence deconvolution microscope for research and training at Lewis & Clark College"
2007-2011 National Science Foundation
"RUI: Cellular and genetic analysis of lysosome and lysosome-related organelle biogenesis in C. elegans"
2005-2007 Murdock College Research Program for Life Sciences
"Investigating a monoclonal antibody that recognizes late-stage apoptotic cells in C. elegans"
2004-2006 Murdock Partners in Science Program "
Genetic analysis of lysosome assembly in C. elegans"
2003-2007 National Science Foundation
"RUI: Genetic and molecular analysis of lysosome assembly and stability in C. elegans"
2002-2004 Murdock College Research Program for Life Sciences
"Investigating the regulation of the Notch receptor, LIN-12, and the Delta ligand, APX-1, during left-right asymmetry in C. elegans organogenesis"
1999-2001 Runyon-Winchell Fellowship
Cancer Research Fund of the Damon Runyon-Walter Winchell Foundation
1998 Riser Dissertation Award
University of Utah
1995-1998 Predoctoral Genetics Training Grant
National Institutes of Health
1995-1996 Graduate Research Fellowship
University of Utah
INVITED REVIEWS:
Hermann, G.J. and Shaw, J.M. (1998) Mitochondrial dynamics in yeast. Annu. Rev. Cell Dev. Biol. 14:265-303.
PUBLICATIONS: (undergraduate co authors are underlined)
Pauw, P.G. and Hermann, G.J. (1994) Ouabain is a reversible inhibitor of myogenic fusion. In Vitro Cell. Dev. Biol., 30A, 9-11.
Hermann, G.J., King, E.J. and Shaw, J.M. (1997) The yeast gene, MDM20, is necessary for mitochondrial inheritance and organization of the actin cytoskeleton. J. Cell Biol. 137: 141-153.
Roeder, A.D., Hermann, G.J., Keegan, B.R., Thatcher, S.A., and Shaw, J.M. (1998) Mitochondrial inheritance is delayed in Saccharomyces cerevisiae cells lacking the serine/threonine phosphatase, PTC1. Mol. Biol. Cell 9: 917-930.
Otsuga, D., Keegan, B.R., Brisch, E., Thatcher, J.W., Hermann, G.J., Bleazard, W. and Shaw, J.M. (1998) The dynamin-related GTPase, Dnm1p, controls mitochondrial morphology in yeast. J. Cell Biol. 143:333-349.
Hermann, G.J., Thatcher, J.W., Mills, J.P., Hales, K.G., Fuller, M.T., Nunnari, J. and Shaw, J.M. (1998) Mitochondrial fusion in yeast requires the transmembrane GTPase Fzo1p. J. Cell Biol. 143:359-373.
Leung, B., Hermann, G.J., and Priess, J.P. (1999) Organogenesis of the C. elegans intestine. Dev. Biol. 216:114-134. pdf
Singer, J., Hermann, G.J. and Shaw, J.M. (2000) Suppressors of mdm20 in yeast identify new alleles of ACT1 and TPM1 predicted to enhance actin-tropomyosin interactions. Genetics. 156:523-534.
Hermann, G.J., Leung, B. and Priess, J.P. (2000) Left-right asymmetry in C. elegans intestine organogenesis involves a LIN-12/Notch signaling pathway. Development. 127:3429-3440. pdf
Starr, D.A., Hermann, G.J., Malone, C.J., Fixen, W., Priess, J.R., Horvitz, H.R., and Han, M. (2001) UNC-83 encodes a novel component of the nuclear envelope and is essential for proper nuclear migration. Development. 128:5039-5050.
Hermann, G.J., Schroeder, L.K., Hieb, C.A., Kershner, A.M., Rabbitts, B.M., Fonarev, P., Grant, B.D., and Priess, J.R. (2005) Genetic analysis of lysosomal trafficking in Caenorhabditis elegans. Mol. Biol. Cell 16:3273-3288. pdf
Eisenhut, R.J., Knox, D., and Hermann, G.J. (2005) Characterization of a conserved apoptotic marker expressed in Caenorhabditis elegans phagocytic cells. Biochem. Biophys. Res. Comm. 335:1231-1238. pdf
Schroeder, L.K., Kremer, S., Kramer, M.J., Currie, E., Kwan, E., Watts, J.L., Lawrenson, A.L., and Hermann, G.J. (2007) Function of the Caenorhabditis elegans ABC transporter PGP-2 in the biogenesis of a lysosome-related fat storage organelle. Mol. Biol. Cell 18:995-1008. pdf
Currie, E ., King, B., Lawrenson, A.L., Schroeder, L.K., Kershner, A.M., and Hermann, G.J. (2007) Role of the Caenorhabditis elegans multidrug resistance gene, mrp-4, in gut granule differentiation. Genetics 177:1569-1582. pdf
Rabbitts, B.M., Kokes, M., Miller, N.E., Kramer, M., Lawrenson, A.L., Levitte, S., Kremer, S., Kwan, E., Weis, A.M. and Hermann, G.J. (2008) glo-3, a novel Caenorhabditis elegans gene, is required for lysosome-related organelle biogenesis. Genetics 180:857-871. pdf
Levitte, S., Salesky, R., King, B., Coe Smith, S., Depper, M., Cole, M., Hermann, G.J., (2010) A C. elegans model of orotic aciduria reveals enlarged lysosome-related organelles in embryos lacking umps-1 function. FEBS J. 277:1420-1439. pdf
Hermann, G.J., Scavarda, E., Weis, A.M., Saxton, D.S., Thomas, L.L., Salesky, R., Somhegyi, H., Curtin, T.P., Barrett, A., Foster, O.K., Vine, A., Erlich, K., Kwan, E., Rabbitts, B.M., Warren, K. (2012) C. elegans BLOC-1 functions in trafficking to lysosome-related gut granules. PLoS ONE 7 (8): e43043.
Delahaye, J.L., Foster, O.K., Vine, A., Saxton, D.S., Curtin, T.P., Somhegyi, H., Salesky, R., Hermann, G.J. (2014) C. elegans HOPS and CCZ-1 mediate trafficking to lysosome-related organelles independently of RAB-7 and SAND-1. Mol. Biol. Cell 25:1073-1096. pdf
Barrett, A. and Hermann, G.J. (2016) A Caenorhabditis elegans homologue of LYST functions in endosome and lysosome-related organelle biogenesis. Traffic 17:515-535. pdf
Fridolfsson, H.N., Herrera, L.A., Brandt, J.N., Cain, N.E., Hermann, G.J. and Starr, D.A. (2018) Genetic analysis of nuclear migration and anchorage to study LINC complexes during development of Caenorhabditis elegans. In The LINC Complexes: Methods and Protocols. Methods in Molecular Biology, Springer. 1840:163-180. pdf
Morris, C., Foster, O.K., Handa, S., Peloza, K., Somhegyi, H., Jian, Y., Vo, M.V., Harp, M., Rambo, F.M., Yang, C., and Hermann, G.J. (2018) Function and regulation of the Caenorhabditis elegans Rab32 family member GLO-1 in lysosome-related organelle biogenesis. PLOS Genetics pgen.1007772.
Voss, L., Foster, O.K., Harper, L., Morris, C., Lavoy, S., Brandt, J.N., Peloza, K., Handa, S., Maxfield, A., Harp, M., King, B., Eichten, V., Rambo, F.M., and Hermann, G.J. (2020) An ABCG transporter functions in Rab localization and lysosome-related organelle biogenesis in Caenorhabditis elegans. Genetics 214:419-445. pdf
Brandt, J.N., Voss, L., Rambo, F.M., Nicholson, K., Thein, J.R., Fairchild, L., Seabrook, L., Lewis, D., Guevara-Hernandez, L., White, M.L., Sax, L., Eichten, V., Harper, L., and Hermann, G.J. (2022) Asymmetric organelle positioning during epithelial polarization of C. elegans intestinal cells. Developmental Biology 481:75-94. pdf
Daniel, M., Parrott, F., Voss, L.A., Shim, Y., Nause, T., Root, B., Loeb, T., Barta, PA., and Hermann, G.J. (2026) The de novo formation and maintenance of C. elegans lysosome-related organelles. Biology Open 15:bio062526. pdf
undergraduate co-authors