Genome design principles (2 credits)

(Dr Aastha Mishra, Dr Kumardeep Chaudhary, Dr Jeetendra Narayan)

The Human Genome Project and its impact on biology and technology

The Encyclopedia of DNA Elements (ENCODE) Project

The International HapMap Project and 1000 Genomes project initiation

Alliance for the Human Epigenome and Disease (AHEAD): The human epigenome project

The evolution of sequencing technologies

Indian Genome Variation project/UK biobank-learnings and applications

Human Microbiome project

Variability in the human genome, methodologies and its role in health and disease

Functional Annotation of the Human genome: identifying of pathogenic variants

Genotype-phenotype association analysis

Defining different approaches for addressing functional DNA elements in the human genome

Computational genomic analysis of microbial communities ? Metagenomics

Computational and Comparative Genomic Biology with an emphasis on structural variation

3D Genome Architecture Organizational Principles

Mapping the architecture of 3D chromosomes

Genomics and Changing paradigms in Biology: Noncoding RNAs, pseudogenes and repetitive sequences

Single-cell genomics and spatial transcriptomics

Personalized medicine: healthcare combining genomics, big data analytics, and population health.

Stems Cells and regenerative medicine (2 credits)

(Dr Chetana Sachidanandan, Dr Sivaprakash Ramalingam, and Dr Debojyoti Chakraborty)

The course will discuss

1. stem cells and pluripotent cells

2. regenerataion in highly regenerative organisms.

3. Organ regeneration, where it happens in humans

4. Organ regeneration, making it happen where it doesn't in human.

The course will discuss each of these aspects through papers and latest advance in each area and what it teaches us about regeneration in general.

Programming for Biologists (2 credits)

(Dr Debasis Dash, Dr Kumardeep Chaudhary)

Basics of programming work environment.

Basics of Matrix Algebra

Matrix and Vector Operations.

Concepts of Algorithms.

File handling and introduction to data types.

Basic programming.

High throughput Data Handling.

Statistical curation of data.

Data clustering using multiple techniques.

Space and Time in Biological Systems (2 credits)

(Dr TN Vivek and Dr Sonam Dhamija)

The different scales of time in biology

How time is defined at the organismal and cellular level

How time delays and periodicity is generated in biological systems

How do network motifs regulate biological processes

Molecular & Cellular mechanisms of defense (2 credits)

(Dr Vivek Rao, Dr Vamsi Krishna Yenamandra)

Self versus non-self

Innate and Adaptive Immunity

The immunologist’s toolbox

Inflammation and immune response in infection and complex disorders-cellular and molecular basis