Genome design principles (2 credits)
(Dr Aastha Mishra, Dr Kumardeep Chaudhary, Dr Jeetendra Narayan)
The Human Genome Project and its impact on biology and technology
The Encyclopedia of DNA Elements (ENCODE) Project
The International HapMap Project and 1000 Genomes project initiation
Alliance for the Human Epigenome and Disease (AHEAD): The human epigenome project
The evolution of sequencing technologies
Indian Genome Variation project/UK biobank-learnings and applications
Human Microbiome project
Variability in the human genome, methodologies and its role in health and disease
Functional Annotation of the Human genome: identifying of pathogenic variants
Genotype-phenotype association analysis
Defining different approaches for addressing functional DNA elements in the human genome
Computational genomic analysis of microbial communities ? Metagenomics
Computational and Comparative Genomic Biology with an emphasis on structural variation
3D Genome Architecture Organizational Principles
Mapping the architecture of 3D chromosomes
Genomics and Changing paradigms in Biology: Noncoding RNAs, pseudogenes and repetitive sequences
Single-cell genomics and spatial transcriptomics
Personalized medicine: healthcare combining genomics, big data analytics, and population health.
Stems Cells and regenerative medicine (2 credits)
(Dr Chetana Sachidanandan, Dr Sivaprakash Ramalingam, and Dr Debojyoti Chakraborty)
The course will discuss
1. stem cells and pluripotent cells
2. regenerataion in highly regenerative organisms.
3. Organ regeneration, where it happens in humans
4. Organ regeneration, making it happen where it doesn't in human.
The course will discuss each of these aspects through papers and latest advance in each area and what it teaches us about regeneration in general.
Programming for Biologists (2 credits)
(Dr Debasis Dash, Dr Kumardeep Chaudhary)
Basics of programming work environment.
Basics of Matrix Algebra
Matrix and Vector Operations.
Concepts of Algorithms.
File handling and introduction to data types.
Basic programming.
High throughput Data Handling.
Statistical curation of data.
Data clustering using multiple techniques.
Space and Time in Biological Systems (2 credits)
(Dr TN Vivek and Dr Sonam Dhamija)
The different scales of time in biology
How time is defined at the organismal and cellular level
How time delays and periodicity is generated in biological systems
How do network motifs regulate biological processes
Molecular & Cellular mechanisms of defense (2 credits)
(Dr Vivek Rao, Dr Vamsi Krishna Yenamandra)
Self versus non-self
Innate and Adaptive Immunity
The immunologist’s toolbox
Inflammation and immune response in infection and complex disorders-cellular and molecular basis