Group leader, Steve, recently presented the team's work at the American Chemical Society Spring Conference (Atlanta, USA) and during seminars at the University of Chicago, Boston University and the Massachusetts Institute of Technology.
We are delighted to have been awarded an EPSRC overseas travel award to explore new collaborations with researchers based in the USA.
Congratulations to Claudia Andrews for successfully defending her MSc by Research thesis!
Our latest work, led by PhD student Fran D'Rozario, titled "Electronic actuation of surface-immobilized, pH-responsive DNA nanoswitches," has been published in ACS Applied Materials & Interfaces! Congratulations to everyone involved!
Our latest work, led by MSc by Research student Claudia, titled "Detergent-triggered membrane remodelling monitored via intramembrane fluorescence dequenching," has been accepted for publication in ACS Omega! Congratulations to everyone involved!
Check out the pre-print here!
Our latest work, led by Dr Jamie Howard, titled "The transitional kinetics between open and closed Rep structures can be tuned by salt via two intermediate states," has been accepted for publication in Nucleic Acids Research.
Check out the pre-print here!
Our latest work, led by former PhD student, Dr Sarah Graham, titled "A DNA scaffold approach facilitates 5' labelling of the SARS-CoV-2 RNA pseudoknot for smFRET investigation" has been accepted for publication in ChemPhysChem.
Check out the pre-print here!
Congratulations to Dr Fran D'Rozario for successfully defending her PhD thesis!
Out latest manuscript, titled "Detergent-triggered membrane remodelling monitored via intramembrane fluorescence de-quenching" is now available on BioRXiv.
Congratulations to Claudia and everyone involved!
Read the pre-print here!
Out latest work, titled "Ultrasensitive Alzheimer's disease biomarker detection with nanopillar photonic crystal biosensors" has been accepted for publication in Optica.
Congratulations to Katie and everyone involved!
Read the pre-print here!
Our latest pre-print, led by former PhD student, Dr Sarah Graham, titled "A DNA scaffold approach facilitates 5' labelling of the SARS-CoV-2 RNA pseudoknot for smFRET investigation" is now available on BioRxiv.
Check out the pre-print here!
Our latest pre-print, led by PhD student Fran D'Rozario, titled "Electronic actuation of surface immobilized, pH-responsive DNA nanoswitches" is now available on BioRxiv.
You can read the pre-print here!
Our latest pre-print, led by Dr Chris Hill, titled "A new protein-dependent riboswitch activates ribosomal frameshifting" is now available on BioRxiv.
You can read the pre-print here!
Congratulations to Dr Sarah Graham for successfully defending her PhD thesis!
Out latest pre-print, titled "Ultrasensitive Alzheimer's disease biomarker detection with nanopillar photonic crystal biosensors" is now available on arXiv!
Read more here!
Steve, Sarah, Francisca and Claudia presented at the national Physics of Life conference held in Harrogate.
Learn more here!
Our latest article which highlights the urgent and global need for democratized blood-based diagnostics for Alzheimer's disease is accepted for publication in The Journal of Precision Medicine: Health and Disease.
Our latest research paper which showcases a resonant Young's slit interferometer for the ultrasensitive detection of Alzheimer's disease biomarkers has been accepted for publication in Biosensors. Congratulations to Katie, Stefanus and Augusto from the teams involved!
We are delighted to welcome Claudia Andrews, Serafina Coupe, Eleanor Goffee, Lauryn Roberts and Emily James to our vesicle- and biophotonics-sensing teams! Welcome!
Our latest research paper which explores interactions between perturbative detergent molecules and lipid vesicles has been accepted for publication in Communications Materials.
We are delighted to welcome Hermia Kung and Débora De Almeida E Magalhaes who join the group on Generation Research Summer studentships. We are also thrilled to welcome Archie Bennett who joins the team on an EPSRC Masterclass placement.
Out latest pre-print, titled "Rep structures can be tuned by ionicity via metastable intermediates in the absence of DNA," is now available on BioRXiv!
Read more here!
Building on 5 years of research, and funded by the Alzheimer's Society & Alzheimer's Research UK, we are developing a simple, cost-effective & light-based blood test technology that could assist with early-stage diagnosis of Alzheimer's.
Read more here.
We have been awarded a grant to install a new single-molecule biophysics suite at the University of York!
Congratulations to Dr Lara Dresser for successfully defending her PhD thesis!
We are thrilled to welcome Katie Morris as a Postdoctoral Research Associate and Abdul Adenopo as a PhD student! Welcome to the group!
Out latest pre-print, titled "Multiple intermediates in the detergent-induced fusion of lipid vesicles," is now available on BioRXiv!
Read more here!
Out latest paper, titled "Multiplexed near-field optical trapping exploiting anapole states," is accepted for publication in ACS Nano! Our work also now features on the journal cover.
Read more here!
Out latest paper, titled "A guide to small fluorescent probes for single-molecule biophysics," has been published! Our work also features on the journal cover.
Read more here!
Out latest paper, titled "Crowding induced morphological changes in synthetic lipid vesicles determined using smFRET," has been accepted for publication.
Read the pre-print here!
Our group have developed a framework for describing protein aggregation observed in Alzheimer's disease!
Read the pre-print here!
Out latest paper, titled "Correlating viscosity and molecular crowding with fluorescent nanobeads and molecular probes: in vitro and in vivo" has been accepted for publication in Interface Focus!
Read the pre-print here!
Our group have discovered the precise way detergents break biological membranes, which could increase our understanding of how soaps work to kill viruses like Covid-19.
Read more here!
Our latest work, now published in Nature Communications, reports ligand-induced conformational changes within single EGFR receptors embedded within model-membrane nanodiscs.
Read the paper here!
Our latest work, now published on the cover of The Journal of Physical Chemistry Letters, demonstrates the use of fluorescence and FRET spectroscopy to monitor conformational changes in single lipid vesicles in response to the widely used detergent Tween-20.
Read the paper here!
Check out the press release here!
Here, we demonstrate the detection of large unilamellar vesicles, which are excellent models of EVs, down to a concentration <10 pM using a dielectric resonant metasurface.
Read more here!
Here we exemplify the capabilities of the ABEL trap in performing extended timescale smFRET measurements on the molecular motor Rep. Read more here!
We have been awarded an equipment grant to develop a core ultrafast spectroscopy and FLIM imaging facility at the University of York.
Our latest work evaluating the mechanism of SDS-induced vesicle solubilization is now featured as a Supplementary Journal Cover.
Read more here!
Here we exemplify the capabilities of the ABEL trap in performing extended timescale smFRET measurements on the molecular motor Rep.
Read more here!
Our latest work evaluating the mechanism of SDS-induced vesicle solubilization will be featured as a Supplementary Journal Cover.
Our latest biophysical toolbox for probing membrane disruption has now been accepted for publication in Langmuir.
Hannah joins the team on a 10 week EPSRC funded Summer placement to apply mathemetical models to single molecule fluorescence data. Welcome Craig!
Hannah joins the team on a 10 week Summer placement to investigate conformational dynamics in proteins. Welcome Hannah!
The COVID-19 pandemic has had a huge impact across all walks of life in the UK, including scientific research. Read here about how our dementia research is adapting.
Our latest single-molecule protocols for probing amyloid oligomerization and toxicity are accepted for publication in Methods as part of the "Correlative approaches in Single-Molecule Biophysics" special edition.
“Steve Quinn’s work on Alzheimer’s disease is a great example of real impactful research - it is fantastic to see how advanced bio-physics techniques can pave the way for future healthcare technologies.”
Our latest work combines fluorescence spectroscopy, atomic force microscopy, single vesicle spectroscopy and electronic sensing to suggest a muti-step mechanism of SDS-induced membrane solubilization.
Read more: tinyurl.com/ycbnsx8e
Steve presented at the Alzheimer's Research UK Virtual Conference. Our goal: to understand protein aggregation, one molecule at a time.
Lara Dresser joins the team as an EPSRC funded PhD student. Welcome Lara!
Our group celebrates moving to a new dedicated biophysics facility – two floors of laboratories and workspaces where experimentalists and theoreticians work together with biologists.
Steve teamed up with Dr. Jamieson Howard, Dr. Maria Dienerowitz and Prof Michael Borsch in Jena, Germany, to test the latest single-molecule optical microscopy tools.
Patrick presents the group's work on detecting amyloid aggregates at the single-molecule level.
We are delighted to have received funding from ARUK to develop new microscopy tools for understanding Alzheimer’s disease at the molecular level.
Hot off the press! Our latest work: a single-molecule toolbox for unravelling the mechanism of detergent-induced membrane solubilisation is now online. Congratulations to everyone involved!
Steve presents the latest research from the group at the 12th EBSA and 10th ICBP-IUPAP Biophysics Congress in Madrid, Spain.
Steve gave the keynote lecture and met a number of aspiring physicists at the Ogden Trust and Isaac Physics Awards evening. Congratulations to all winners!
Understanding and preventing Alzheimer's disease is a major challenge. Fatima joins the team to develop new optical microscopy tools for investigating the earliest stages of the disease. Welcome Fatima!
Congratulations to Patrick Hunter who joins the team as a Physics of Life UK Summer Bursary recipient. Patrick will use advanced single-molecule fluorescence tools to probe the molecular building blocks of Alzheimer's disease.
The Physics of Life away day brought together a highly motivated team of physicists, biologists, chemists, mathematicians and engineers to tackle major open questions related to human life and disease.
Interdisciplinary scientists convened for talks highlighting the role of light in measuring and manipulating biological systems. Adding breadth to the topics covered, Steve provided a lecture on single-molecule microscopy tools.
The fourth international conference on Fluorescent Biomolecules and their Building Blocks (FB3) was held in Glasgow, UK from Sat 30th June to Tue 3rd July, 2018.