Publications

Full Listing of Published Work and Pubmed Link

Peer-Reviewed Original Research below: (oldest to newest)

1. Cruz-Monserrate Z, Vervoort HC, Bai R, Newman DJ, Howell SB, Los G, Mullaney JT, Williams MD, Pettit GR, Fenical W, Hamel E. Diazonamide A and a synthetic structural analog: disruptive effects on mitosis and cellular microtubules and analysis of their interactions with tubulin. Mol Pharmacol 2003 63(6):1273-80, PMID: 12761336

2. Cruz-Monserrate Z, Mullaney JT, Harran PG, Pettit GR, Hamel E. Dolastatin 15 binds in the vinca domain of tubulin as demonstrated by Hummel-Dreyer chromatography. Eur J Biochem 2003 Sep;270(18):3822-8. PMID: 12950266

3. Cruz-Monserrate Z, Qiu S, Evers BM, O'Connor KL. Upregulation and redistribution of integrin alpha6beta4 expression occurs at an early stage in pancreatic adenocarcinoma progression. Mod Pathol. 2007 Jun;20(6):656-67 PMID: 17415382

4. Cruz-Monserrate Z, O'Connor KL. Integrin alpha 6 beta 4 promotes migration, invasion through Tiam1 upregulation, and subsequent Rac activation. Neoplasia 2008 May;10(5):408-17. PMID: 18472958

5. Abd-Elgaliel WR*, Cruz-Monserrate Z*(Co-first author), Logsdon CD, Tung CH. Molecular imaging of Cathepsin E-positive tumors in mice using a novel protease-activatable fluorescent probe. Mol Biosyst 2011 Dec;7(12):3207-13 PMID: 21935563

6. Cruz-Monserrate Z, Abd-Elgaliel WR, Grote T, Deng D, Ji B, Arumugam T, Wang H, Tung CH, Logsdon CD. Detection of pancreatic cancer tumours and precursor lesions by cathepsin E activity in mouse models. Gut. 2012 Sep;61(9):1315-22 PMID: 22068166

7. Daniluk J, Liu Y, Deng D, Chu J, Huang H, Gaiser S, Cruz-Monserrate Z, Wang H, Ji B, Logsdon CD. An NF-κB pathway-mediated positive feedback loop amplifies Ras activity to pathological levels in mice. J Clin Invest. 2012 Apr 2;122(4):1519-2 PMID: 22406536

8. Abd-Elgaliel WR*, Cruz-Monserrate Z*(Co-first author), Wang H, Logsdon CD, Tung CH. Pancreatic Cancer-Associated Cathepsin E as a Drug Activator. Journal of Controlled Release 2013 May 10;167(3):221-7 PMID: 23422726

9. Philips B., Roland CL., Daniluk J., Liu Y., Chatterjee D., Gomez SB., Ji B, Huang H., Wang H, Fleming JB., Logsdon CD and Cruz-Monserrate Z. High-Fat Induces PanINs via an Oncogenic K-Ras Cox-2 Feed-Forward Loop. Gastroenterology, Gastroenterology 2013 Dec;145(6):1449-58. PMID: 23958541 Corresponding author

10. Cruz-Monserrate Z., Roland CL., Deng D., Arumugam T, Moshnikova A, Andreev O., Reshetnyak Y., and Logsdon CD. Targeting Pancreatic Ductal Adenocarcinoma Acidic Microenvironment. Scientific Reports 2014 Mar 19;4:4410 PMID: 24642931

11. Roland CL, Arumugam T, Deng D, He S., Philip B., Gomez S., Ramachandran V., Wang H., Cruz-Monserrate Z., and Logsdon CD. Cell surface lactate receptor GPR81 is crucial for cancer cell survival. Cancer Research 2014 Sep 15;74(18):5301-10 PMID: 24928781

12. Gonzalez-Villasana V., Rodriguez-Aguayo C., Arumugam T, Cruz-Monserrate Z., Fuentes-Mattei E., Deng D., Hwang RF., Wang H., Ivan C., Garza RJ., Cohen E., Gao H., Armaiz-Pena GN., Monroig-Bosque PD., Philip B., Rashed MH., Aslan B., Alper Erdogan M., Gutierrez-Puente Y., Ozpolat B., Reuben JM., Sood AK., Logsdon CD., Lopez-Berestein G.. Bisphosphonates Inhibit Stellate Cell Activity and Enhance Antitumor Effects of Nanoparticle Albumin Bound-Paclitaxel in Pancreatic Ductal Adenocarcinoma. Molecular Cancer Therapeutics 2014 Nov;13(11):2583-94. PMID: 25193509

13. Mohammed A., Janakiram NB., Madka V., Brewer M., Ritchie RL., Lightfoot S., Kumar G., Sadeghi M., Patlolla JMR., Cruz-Monserrate Z., May R., Houchen C., Steele VE. and Rao CV. Targeting pancreatitis blocks tumor-initiating stem cells and pancreatic cancer progression. Oncotarget 2015 Jun 20;6(17):15524-39 PMID: 25906749

14. Fu Y*., Cruz-Monserrate Z.* (Co-first author), Lia HH, Chung Y, Ji B, Lin S, Vonderfecht S, Logsdon CD, Li C, Ann DK. Oncogenic KRASG12V induces salivary ductal carcinoma in mice. Scientific Reports; 2015 Aug 20;5:13347. PMID: 26289340

15. Hart PA TM, Raimondo M, Cruz-Monserrate Z, Fisher WE, Lesinski GB, Steen H, Conwell DL. Endoscopic pancreas fluid collection: methods and relevance for clinical care and translational science Am J Gastroenterol 2016 Sep;111(9):1258-66 PMID: 27481304

16. Cruz-Monserrate Z, Conwell DL, and Krishna SG. The Impact of Obesity on Gallstone Disease, Acute Pancreatitis and Pancreatic Cancer. Invited review article, Gastroenterology Clinics 2016 PMID: 27837777

17. Hart PA TM, Bellin MD. Andersen DK., Bradley D., Cruz-Monserrate Z, Forsmark CE., Goodarzi MO., Habtezion A., Korc M., Kudva YC., Pandol SJ., Whitcomb DC., Yadav D., and Chari ST. Type 3c (pancreatogenic) diabetes mellitus secondary to chronic pancreatitis and pancreatic cancer Lancet 2016 PMID: 28404095

18. Mace TA, Shakya R, Pitarresi JR, Swanson B, McQuinn CW, Loftus S, Nordquist E, Cruz-Monserrate Z, Yu L, Young G, Zhong X, Zimmers TA, Ostrowski MC, Ludwig T, Bloomston M, Bekaii-Saab T, Lesinski GB. IL-6 and PD-L1 antibody blockade combination therapy reduces tumour progression in murine models of pancreatic cancer. Gut. 2016 PMID: 27797936

19. Gaziova I., Jackson D., Boor P., Carter D, Cruz-Monserrate Z., Elferink C., Joshi A., Kaphalia B., Logsdon C., Soong L., Xao X., Qiu S., and Elferink L. The MET receptor tyrosine kinase confers repair of murine pancreatic acinar cells following acute and chronic injury. PLOS ONE 2016 PMID: 27798657

20. Swidnicka-Siergiejko AK., Gomez SB., Badi N., Cruz-Monserrate Z., Deng D., Huang H., Ji B, Azizian N., Daniluk J., Weiqin L., Wang H, Maitra A., and Logsdon CD. Chronic inflammation initiates multiple forms of K-Ras-independent mouse pancreatic cancer in the absence of TP53 Oncogene 2016 PMID: 27991926

21. Shapiro J., Komar H., Hart P., Cruz-Monserrate Z., Conwell D., and Lesinski GB. Laser Laser capture microdissection of pancreatic acinar cells to identify proteomic alterations in a murine model of caerulein-induced pancreatitis. Clinical and Translational Gastroenterology 2016 PMID: 28406494

22. Krishna SG, Hussan H, Cruz-Monserrate Z., Conteh L., Mumtaz K., and Conwell DL. A Review of the Impact of Obesity on Common Gastrointestinal Malignancies Invited review article Integrative Cancer Science and Therapeutics 2016 DOI: 10.15761/ICST.1000223 PMID: 28819564

23. Gomez SB., Swidnicka-Siergiejko AK., Badi N., Chavez-Tomar M., Lesinski GB., Bekaii-Saab T., Farren MR., Mace TA., Schmidt C., Liu Y., Deng D., Hwang RF., Zhou L., Moore T., Chatterjee D., Wang H, Leng X., Arlinghaus RB., Logsdon CD., and Cruz-Monserrate Z. Lipocalin-2 Promotes Pancreatic Ductal Adenocarcinoma by Regulating Inflammation in the Tumor Microenvironment. Cancer Research 2017 PMID: 28249896 Corresponding author

24. Mody H., Wai Hung S., Pathak R., Griffin J., Cruz-Monserrate Z., and Govindarajan R. MicroRNA 202-5p diminishes TGFβ receptor expressions and attenuates TGFβ1-induced EMT in pancreatic cancer. Molecular Cancer Research 2017 PMID: 28373289

25. Eibl G., Cruz-Monserrate Z, Korc M., Petrov MS., Goodarzi MO., Fisher WE., Habtezion A., Lugea A., Pandol SJ., Hart PA TM, and Andersen DK; Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer. Diabetes Mellitus and Obesity as Risk Factors for Pancreatic Cancer. Journal of the Academy of Nutrition and Dietetics 2017 PMID: 28919082

26. Nemer L., Krisna SG., Shah Z., Conwell DL., Cruz-Monserrate Z., Dillhoff M., Guttridge D., Hinton A., Manilchuk A., Pawlik TM., Schmidt C., Talbert E., Bekaii-Saab T., and Hart PA. Predictors of pancreatic cancer-associated weight loss and nutritional interventions. Pancreas 2017 PMID: 28902785

27. Komar HM., Hart PA., Cruz-Monserrate Z., Conwell DL., and Lesinski GB. Local and Systemic Expression of Immunomodulatory Factors in Chronic Pancreatitis. Pancreas. 2017 PMID: 28796136

28. Malli A., Li F., Conwell DL., Cruz-Monserrate Z., Hussan H., and Krishna S.G. The Burden of Systemic Adiposity on Pancreatic Disease: Acute Pancreatitis, Non-Alcoholic Fatty Pancreas Disease, and Pancreatic Cancer. Journal of the Pancreas. 2017 PMID: 29491829

29. Li F.,Malli A., Cruz-Monserrate Z., Conwell DL., and Krisna SG. Confocal endomicroscopy and cyst fluid molecular analysis: Comprehensive evaluation of pancreatic cysts. World Journal of Gastrointestinal Endoscopy. 2018 10(1), 1-9. doi:10.4253/wjge.v10.i1.1 PMID: 29375735

30. Abbruzzese J. L., Anderson D. K., Borrebaeck C. A. K., Chari S. T., Costello E., Cruz-Monserrate Z., Eibl G., Engleman E. G., Fisher W. E., Habtezion A., Kim S. K., Korc M., Logsdon C., Lyssiotis C. A., Pandol S. J., Rustgi A., Wolfe B M., Zheng L., and Powers A. C. The Interface of Pancreatic Cancer With Diabetes, Obesity and Inflammation: Research Gaps and Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop. Pancreas. 2018 PMID: 29702529

31. Bennike, T., Bellin, M., Xuan, Y., Stensballe, A., Møller, F.,Beilman, G.,Levy, O., Cruz-Monserrate, Z., Andersen, V., Steen, J., Conwell, D., Steen, H. A cost-effective high throughput plasma and serum proteomics workflow enables mapping of the molecular impact of total pancreatectomy with islet autotransplantation. Journal of Proteome Research 2018 17(5), 1983-1992 PMID: 29641209

32. Krishna SG, Rawal V, Durkin C, Modi R, Hinton A, Cruz-Monserrate Z, Conwell DL, Hussan H. Weight Loss Surgery Reduces Healthcare Resource Utilization and All-Cause Inpatient Mortality in Morbid Obesity: a Propensity-Matched Analysis. Obes Surg. 2018 Jun 21 PMID: 29931480

33. Fisher WE., Cruz-Monserrate Z., McElhany AL., Lesinski GB., Hart P., Ghosh R., Rinaudo JS., Serrano J., Srivastava S., Mace T., Topazian MD., Feng Z, Yadav D., Pandol SJ., Hughes SJ., Liu RY., Orr R., Whitcomb DC., Abouhamze AS., Steen H., and Conwell DL. Standard Operating Procedures for Biospecimen Collection, Processing, and Storage for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer Pancreas 2018 47(10):1213-1221 PMID: 30325860

34. Ramsey M; Talbert E; Ahn D; Bekaii-Saab T; Badi N; Bloomston PM; Conwell DL; Cruz-Monserrate Z; Dillhoff M; Farren MR; Hinton A; Krishna SG; Lesinski GB; Mace T; Manilchuk A; Noonan A; Pawlik TM; Rajasekera PV; Schmidt C; Guttridge D; Hart PA. Circulating interleukin-6 is associated with disease progression, but not cachexia in pancreatic cancer. Pancreatology 2018 (in press)