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Introduction:
Methodology development and application of cryoEM, cryoFIB/SEM and cryoET aiming to investigate regulation mechanism of ubiquitin-proteasome system (UPS) for protein degradation in neurodegenerative diseases, HIV capsid and co-factors interactions and in situ structure and assembly of methane oxidation enzymes.
Methodology development and application of cryoEM, cryoFIB/SEM and cryoET aiming to investigate regulation mechanism of ubiquitin-proteasome system (UPS) for protein degradation in neurodegenerative diseases, HIV capsid and co-factors interactions and in situ structure and assembly of methane oxidation enzymes.
1. Methodological development in cryoEM, cryoET and subtomogram averaging. (Zhu, et al, BMC bioinformatics, 2017; Zhu, et al, Structure, 2020)
2. Molecular mechanism of methane oxidation in methanotrophic bacteria. (Zhu, et al, Nature Communications, 2022)
3. Molecular mechanism of protein degradation in neurodegenerative diseases. (Zhu, et al, Nature Communications 2018; Dong, et al, Nature, 2019; Lee, Zhu, et al, Molecular Cell, 2023)
4. In situ study of pathogen host interactions. (Ni, Zhu, et al, Science Advances, 2021; Waheed, Zhu, et al, PNAS, 2023; Kleinpeter, Zhu, et al, JMB, 2023; Ni, Mendonca, Zhu, et al, iScience, 2023)
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