Zhu Lab

Catching proteins at play: the method revealing the cell’s inner mysteriesCryo-electron tomography is a hugely promising tool in visual proteomics — if researchers can work out what they are seeing.

Meet the authors: Ying Lu, Donghoon Lee, and Yanan ZhuWe talk to co-first authors Donghoon Lee and Yanan Zhu and co-corresponding author Ying Lu about their paper “Molecular mechanism for activation of the 26S proteasome by ZFAND5” (this issue of Molecular Cell), the challenges of the project, their scientific pathways, and the late Dr. Alfred Goldberg.

New technique solves HIV capsid structure and could be blueprint of capsid-targeting antiviralsA new technique using electron tomography and subtomogram averaging at Diamond’s electron Bio-Imaging Centre (eBIC), has solved the structure of the HIV capsid alone and in complex with host factors. This work also led to the building of an atomistic model of the whole HIV capsid using information gained from electron tomography, which the team believe could serve as a blueprint for the development of capsid-targeting antivirals.

Technique Solves HIV Capsid Structure; Could Serve as Blueprint for Capsid-Targeting AntiviralsScientists use pore-forming toxin to punch holes in the membrane of HIV virus-like particles, making the capsid accessible to external cell factors and small molecules.

Strategic advances in HIV research | UDailyUD's Juan Perilla and team produce high-precision model of HIV dynamics in collaboration with Oxford

Novel technique solves structure of the HIV capsid alone and in complex with host factorsA new technique using electron tomography and subtomogram averaging at Diamond's electron Bio-Imaging Centre (eBIC), has solved the structure of the HIV capsid alone and in complex with host factors.

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