Publications

The trajectory taken by dimeric Cu/Zn superoxide dismutase through the protein unfolding and dissociation landscape is modulated by salt-bridge formation

L McAlary, J Harrison, JA Aquilina, S Fitzgerald, C Kelso, JLP Benesch, ...

Analytical Chemistry

The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins

V Deora, JD Lee, EA Albornoz, L McAlary, CJ Jagaraj, AAB Robertson, ...

Glia

Using tetracysteine-tagged TDP-43 with a biarsenical dye to monitor real-time trafficking in a cell model of Amyotrophic Lateral Sclerosis

JSW Ng, MA Hanspal, NS Matharu, TP Barros, EK Esbjörner, MR Wilson, ...

Biochemistry 58 (39), 4086-4095

The Ubiquitin Proteasome System Is a Key Regulator of Pluripotent Stem Cell Survival and Motor Neuron Differentiation

M Bax, J McKenna, D Do-Ha, CH Stevens, S Higginbottom, R Balez, ...

Cells 8 (6), 581

Dynamic interplay between H-current and M-current controls motoneuron hyperexcitability in amyotrophic lateral sclerosis

Y Buskila, O Kékesi, A Bellot-Saez, W Seah, T Berg, M Trpceski, ...

Cell death & disease 10 (4), 310

The metastability of the proteome of spinal motor neurons underlies their selective vulnerability in ALS

JJ Yerbury, L Ooi, IP Blair, P Ciryam, CM Dobson, M Vendruscolo

Neuroscience Letters. 704, 89-94

Pathological spreading of TDP-43 studied in real time: Impaired microglia function leads to propagation of TDP-43 along the axon and into surrounding tissue

AJ Svahn, EK Don, R Radford, NJ Cole, A Lee, J Yerbury, MB Graeber, ...

BRAIN PATHOLOGY 29, 127-127

Prion-Like Propagation of Protein Misfolding and Aggregation in Amyotrophic Lateral Sclerosis

L McAlary, SS Plotkin, JJ Yerbury, N Cashman

Frontiers in molecular neuroscience 12, 262

Novel behavioural characteristics of the superoxide dismutase 1 G93A (SOD1G93A ) mouse model of amyotrophic lateral sclerosis include sex-dependent phenotypes.

F Kreilaus, S Guerra, R Masanetz, V Menne, J Yerbury, T Karl

Genes, Brain and Behaviour, doi: 10.1111/gbb.12604. [Epub]

Strategies to promote the maturation of ALS-associated SOD1 mutants: small molecules return to the fold

L McAlary, JJ Yerbury

Neural Regeneration Research 14 (9), 1511-1512

CuATSM Protects Against the In Vitro Cytotoxicity of Wild-Type-Like Copper–Zinc Superoxide Dismutase Mutants but not Mutants That Disrupt Metal Binding

NE Farrawell, MR Yerbury, SS Plotkin, L McAlary, JJ Yerbury

ACS chemical neuroscience 10 (3), 1555-1564

Tryptophan 32-mediated SOD1 aggregation is attenuated by pyrimidine-like compounds in living cells

E Pokrishevsky, L McAlary, NE Farrawell, B Zhao, M Sher, JJ Yerbury, ...

Scientific reports 8 (1), 15590

Nucleo-cytoplasmic transport of TDP-43 studied in real time: impaired microglia function leads to axonal spreading of TDP-43 in degenerating motor neurons

AJ Svahn, EK Don, AP Badrock, NJ Cole, MB Graeber, JJ Yerbury, ...

Acta neuropathologica 136 (3), 445-459

Association of regulatory T-cell expansion with progression of amyotrophic lateral sclerosis: a study of humans and a transgenic mouse model

RK Sheean, FC McKay, E Cretney, CR Bye, ND Perera, D Tomas, ...

JAMA neurology 75 (6), 681-689

Association of regulatory T-cell expansion with progression of amyotrophic lateral sclerosis: a study of humans and a transgenic mouse model

RK Sheean, FC McKay, E Cretney, CR Bye, ND Perera, D Tomas, ...

JAMA neurology 75 (6), 681-689

SOD1A4V aggregation alters ubiquitin homeostasis in a cell model of ALS

NE Farrawell, I Lambert-Smith, K Mitchell, J McKenna, L McAlary, ...

J Cell Sci 131 (11), jcs209122

Dysregulation of microRNA biogenesis machinery and microRNA/RNA ratio in skeletal muscle of amyotrophic lateral sclerosis mice

AP Russell, L Ghobrial, S Ngo, J Yerbury, E Zacharewicz, R Chung, ...

Muscle & nerve 57 (5), 838-847

The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation

MJ Capper, GSA Wright, L Barbieri, E Luchinat, E Mercatelli, L McAlary, ...

Nature communications 9 (1), 1693

Assessment of metal concentrations in the SOD1G93A mouse model of amyotrophic lateral sclerosis and its potential role in muscular denervation, with particular focus on muscle …

TG Enge, H Ecroyd, DF Jolley, JJ Yerbury, B Kalmar, A Dosseto

Molecular and Cellular Neuroscience 88, 319-329

Some diseases, like mine, deteriorate rapidly-disability services need to keep up

The Conversation

JJ Yerbury

Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagy

A Lee, SL Rayner, SSL Gwee, A De Luca, H Shahheydari, ...

Cellular and molecular life sciences 75 (2), 335-354

Clusterin protects neurons against intracellular proteotoxicity

JM Gregory, DR Whiten, RA Brown, TP Barros, JR Kumita, JJ Yerbury, ...

Acta neuropathologica communications 5 (1), 81

The heat shock response in neurons and astroglia and its role in neurodegenerative diseases

R San Gil, L Ooi, JJ Yerbury, H Ecroyd

Molecular neurodegeneration 12 (1), 65

Casein kinase II phosphorylation of cyclin F at serine 621 regulates the Lys48-ubiquitylation E3 ligase activity of the SCF^{(cyclin F)} complex

A Lee, SL Rayner, A De Luca, SSL Gwee, M Morsch, V Sundaramoorthy, ...

Open biology 7 (10), 170058

Improving the delivery of SOD1 antisense oligonucleotides to motor neurons using calcium phosphate-lipid nanoparticles

L Chen, C Watson, M Morsch, NJ Cole, RS Chung, DN Saunders, ...

Frontiers in neuroscience 11, 476

The relevance of contact-independent cell-to-cell transfer of TDP-43 and SOD1 in amyotrophic lateral sclerosis

MA Hanspal, CM Dobson, JJ Yerbury, JR Kumita

Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1863 (11) 2762-2771

Addition of exogenous SOD1 aggregates causes TDP-43 mislocalisation and aggregation

R Zeineddine, NE Farrawell, IA Lambert-Smith, JJ Yerbury

Cell stress and chaperones 22 (6), 893-902

P2X7 receptor antagonism in amyotrophic lateral sclerosis

R Sluyter, R Bartlett, D Ly, JJ Yerbury

Neural Regeneration Research 12 (5), 749-750

Flow Cytometric Measurement of the Cellular Propagation of TDP-43 aggregation.

R Zeineddine, DR Whiten, NE Farrawell, L McAlary, MA Hanspal, ...

Prion 11 (3), 195-204

Spinal motor neuron protein supersaturation patterns are associated with inclusion body formation in ALS

P Ciryam, IA Lambert-Smith, DM Bean, R Freer, F Cid, GG Tartaglia, ...

Proceedings of the National Academy of Sciences 114 (20), E3935–E3943

P2X7 antagonism using Brilliant Blue G reduces body weight loss and prolongs survival in female SOD1G93A amyotrophic lateral sclerosis mice.

R Bartlett, V Sluyter, D Watson, R Sluyter, JJ Yerbury

PeerJ 5, e3064

Longitudinal assessment of metal concentrations and copper isotope ratios in the G93A SOD1 mouse model of amyotrophic lateral sclerosis

TG Enge, H Ecroyd, DF Jolley, JJ Yerbury, A Dosseto

Metallomics 9 (2), 161-174

CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia

KL Williams, S Topp, S Yang, B Smith, JA Fifita, ST Warraich, KY Zhang, ...

Nature communications 7, 11253

The P2X7 receptor in amyotrophic lateral sclerosis

R Bartlett, D Watson, V Sluyter, JJ Yerbury, R Sluyter

European Journal Of Immunology 46 (S1), 565-566

Susceptibility of mutant SOD1 to form a destabilized monomer predicts cellular aggregation and toxicity but not in vitro aggregation propensity

L McAlary, AJ Aquilina, JJ Yerbury

Frontiers in Neuroscience 10, 499

Molecular Origami: the Importance of Managing Protein Folding

JJ Yerbury

Australian Biochemist 47 (2), 3

Rapid flow cytometric measurement of protein inclusions and nuclear trafficking

DR Whiten, R San Gil, L McAlary, JJ Yerbury, H Ecroyd, MR Wilson

Scientific Reports 6, 31138

Protein aggregates stimulate macropinocytosis facilitating their propagation

JJ Yerbury

Prion 10 (2), 119-126

Disease Mechanisms in ALS: Misfolded SOD1 Transferred Through Exosome-Dependent and Exosome-Independent Pathways

JM Silverman, SM Fernando, LI Grad, AF Hill, BJ Turner, JJ Yerbury, ...

Cellular and Molecular Neurobiology 36 (3), 377-81

Walking the tightrope: Proteostasis and neurodegenerative disease.

JJ Yerbury, L Ooi, A Dillin, DN Saunders, DM Hatters, PM Beart, ...

Journal of Neurochemistry 137 (4), 489-505

Network Approaches to the Understanding of Alzheimer's Disease: From Model Organisms to Humans.

JJ Yerbury, D Bean, G Favrin

Methods Mol Biol. 1303, 447-58

SOD1 protein aggregates stimulate macropinocytosis in neurons to facilitate their propagation

R Zeineddine, JF Pundavela, L Corcoran, EM Stewart, D Do-Ha, M Bax, ...

Molecular neurodegeneration 10, 57

Expansion of suppressor tregs by IL-2/IL-2 MAB complexes slows disease progression in the mutant SOD1 mouse model of ALS

R Sheean, F McKay, E Cretney, K Scheller, N Perera, J Yerbury, S Vucic, ...

Journal of Neurochemistry 134, 206-207

Evaluation of skin fibroblasts from amyotrophic lateral sclerosis patients for the rapid study of pathological features

S Yang, KY Zhang, R Kariawasam, M Bax, JA Fifita, L Ooi, JJ Yerbury, ...

Neurotoxicity research 28 (2), 138-146

The Role of Macropinocytosis in the Propagation of Protein Aggregation Associated with Neurodegenerative Diseases.

R Zeineddine, JJ Yerbury

Frontiers in Physiology 6, 277

Distinct partitioning of ALS associated TDP-43, FUS and SOD1 mutants into cellular inclusions

NE Farrawell, IA Lambert-Smith, ST Warraich, IP Blair, DN Saunders, ...

Scientific Reports 5, 13416

SerpinB2 (PAI-2) Modulates Proteostasis via Binding Misfolded Proteins and Promotion of Cytoprotective Inclusion Formation

JA Lee, JJ Yerbury, N Farrawell, RF Shearer, P Constantinescu, ...

PLOS ONE 10 (6), e0130136

The interplay of protein aggregates, microglia and neuroinflammation in neurodegenerative disease

S Hook, JR Roberts, Kate, Kumita, J Yerbury Justin

Microglia: Physiology, Regulation and Health Implications, 157-204

Misfolded polyglutamine, polyalanine, and superoxide dismutase 1 aggregate via distinct pathways in the cell

S Polling, YF Mok, YM Ramdzan, BJ Turner, JJ Yerbury, AF Hill, ...

Journal of Biological Chemistry 289 (10), 6669-6680

Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and-independent mechanisms

LI Grad, JJ Yerbury, BJ Turner, WC Guest, E Pokrishevsky, MA O’Neill, ...

Proceedings of the National Academy of Sciences 111 (9), 3620-3625

Extracellular wildtype and mutant SOD1 induces ER–Golgi pathology characteristic of amyotrophic lateral sclerosis in neuronal cells

V Sundaramoorthy, AK Walker, J Yerbury, KY Soo, MA Farg, V Hoang, ...

Cellular and molecular life sciences 70 (21), 4181-4195

Extracellular aggregated Cu/Zn superoxide dismutase activates microglia to give a cytotoxic phenotype

K Roberts, R Zeineddine, L Corcoran, W Li, IL Campbell, JJ Yerbury

Glia 61 (3), 409-419

P2X7 receptor activation induces reactive oxygen species formation and cell death in murine EOC13 microglia

R Bartlett, JJ Yerbury, R Sluyter

Mediators of inflammation 2013, 271813

Intercellular propagated misfolding of wild-type Cu-Zn superoxide dismutase.

LI Grad, JJ Yerbury, BJ Turner, WC Guest, E Pokrishevsky, MA O'Neill, ...

Prion 7, 76-76

Glutathionylation potentiates benign superoxide dismutase 1 variants to the toxic forms associated with amyotrophic lateral sclerosis.

L McAlary, JJ Yerbury, AJ Andrew

Scientific Reports 3, 3275

Protease-activated alpha-2-macroglobulin can inhibit amyloid formation via two distinct mechanisms

AR Wyatt, P Constantinescu, H Ecroyd, CM Dobson, MR Wilson, ...

FEBS letters 587 (5), 398-403

The small heat shock proteins αB-crystallin and Hsp27 suppress SOD1 aggregation in vitro

JJ Yerbury, D Gower, L Vanags, K Roberts, JA Lee, H Ecroyd

Cell Stress and Chaperones 18 (2), 251-257

Extracellular Chaperones and Proteostasis

AR Wyatt, JJ Yerbury, H Ecroyd, MR Wilson

Annual Review of Biochemistry 82 (1), 295-322

Extracellular Chaperones

R Dabbs, AR Wyatt, JJ Yerbury, H Ecroyd, MR Wilson

Topics in Current Chemistry 328, 241-268

Roles of Extracellular Chaperones in Amyloidosis

AR Wyatt, JJ Yerbury, R Dabbs, MR Wilson

Journal of Molecular Biology 421 (4-5), 499-516

Clusterin facilitates in vivo clearance of extracellular misfolded proteins

AR Wyatt, JJ Yerbury, P Berghofer, I Greguric, A Katsifis, CM Dobson, ...

Cellular and Molecular Life Sciences 68 (23), 3919-3931

ANS binding reveals common features of cytotoxic amyloid species

B Bolognesi, JR Kumita, TP Barros, EK Esbjorner, LM Luheshi, ...

ACS chemical biology 5 (8), 735-740