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Funding

Our research is supported by the NUS Yong Loo Lin School of Medicine (NUHSRO/2020/124/TMR/LOA), the Singapore National Medical Research Council (NMRC) LCG (OFLCG19May-0035), NMRC CTG-IIT (CTGIIT23jan-0001), NMRC STaR (STaR20nov-0003), Singapore Ministry of Health (MOH) Centre Grant (CG21APR1009), the Temasek Foundation (TF2223-IMH-01), and the United States National Institutes of Health  (R01MH120080 & R01MH133334). Our computational work was partially performed on resources of the National Supercomputing Centre, Singapore (https://www.nscc.sg). Any opinions, findings and conclusions or recommendations expressed in this material are those of the authors and do not reflect the views of the Singapore NMRC, MOH or Temasek Foundation.