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Funding

Our research is supported by the NUS Yong Loo Lin School of Medicine (NUHSRO/2020/124/TMR/LOA), the Singapore National Medical Research Council (NMRC) LCG (OFLCG19May-0035), NMRC CTG-IIT (CTGIIT23jan-0001), NMRC OF-IRG (OFIRG24jan-0030), NMRC STaR (STaR20nov-0003), Singapore Ministry of Health (MOH) Centre Grant (CG21APR1009), the Temasek Foundation (TF2223-IMH-01), and the United States National Institutes of Health  (R01MH120080 & R01MH133334). Our computational work was partially performed on resources of the National Supercomputing Centre, Singapore (https://www.nscc.sg). Any opinions, findings and conclusions or recommendations expressed in this material are those of the authors and do not reflect the views of the Singapore NMRC, MOH, Temasek Foundation or USA NIH.