Computational Brain Imaging Group

There is a deluge of data across many scientific disciplines. Future scientific breakthroughs will rely on algorithms to explore these massive data. Our group develops machine learning algorithms to automatically generate scientific discoveries from large-scale datasets comprising thousands of subjects with brain magnetic resonance imaging (MRI), behavioral, genetic and other physiological measures.


Information processing in the human brain arises from 100 billion neurons connected by 100 trillion synapses into a complex network. MRI allows us to non-invasively study brain networks of living individuals. By exploring large multi-modal datasets, we seek to discover fundamental principles of brain network organization, how brain networks are organized to support cognition and how brain networks are disrupted in mental disorders.

News

    • 7/2021: Christopher Chen (NUS) gave a talk to our center

    • 6/2021: Emily Jacobs (UC Santa Barbara) gave a talk to our center

    • 4/2021: Congrats to Valeria for being a finalist for the Somerfeld-Ziskind Research Award

    • 3/2021: John Murray (Yale) gave a talk to our center

    • 2/2021: Our paper on individual-level cerebellum organization is out [free download]

    • 2/2021: Lucina Uddin (University of Miami) gave a talk to our center

    • 1/2021: Welcome Naren and Yan Quan to our group!

    • 11/2020: Congrats to Tong He for defending his PhD thesis

    • 10/2020: Nico Dosenbach (Washington University at St. Louis) gave a talk to our center

    • 9/2020: Jean Chen (U Toronto) gave a talk to our center

    • 8/2020: Our paper on predicting Alzheimer's Disease progression is out in NeuroImage [free download] [code]

    • 8/2020: Caterina Gratton (Northwestern) gave a talk to our center

    • 8/2020: Welcome Pansheng, Terence, Frederick, Kang Wei, Nicholas Alexander and Xintong to our group!

    • 6/2020: Our paper on reconciling dimensional and categorical models of autism heterogeneity is now out in Biological Psychiatry [free download]

    • 5/2020: Simon Eickhoff (Heinrich-Heine University Düsseldorf) gave a talk to our center

    • 4/2020: Avram Holmes (Yale) gave a talk to our center

    • 4/2020: Justin Baker (Harvard Medical School) gave a talk to our center

    • 2/2020: Our paper on global signal amplitude decreasing with time of day is out in PLoS Biology [free download] [science daily]

    • 2/2020: Our paper on DNN and kernel regression achieving similar RSFC behavioral prediction performance is out in NeuroImage [free download] [code]

    • 12/2019: Congrats to Nanbo for successfully defending his thesis!

    • 11/2019: Congrats to Jingwei for successfully defending her thesis!

    • 11/2019: Our papers on multimodal AD heterogeneity and single-hemisphere intrinsic FC are out respectively on NeuroImage [paper] [code] and Cell Reports [free download]

    • 9/2019: Our paper showing that deep neural networks and kernel regression achieve comparable RSFC-based behavioral prediction is in press in NeuroImage [preprint] [code]

    • 8/2019: Our paper on somatosensory-motor dysconnectivity spannning multiple transdiagnostic dimensions of psychopathology is now in press at Biological Psychiatry [pdf]

    • 8/2019: Danilo Bzdok (Aachen) visited our group

    • 8/2019: Good luck to Nanbo Sun, Qing Yang, Nicole Kuek and Minh Nguyen in their future endeavor!

    • 8/2019: Welcome Leon and Xiaoxuan to our group!

    • 7/2019: John Murray (Yale) visited our group

    • 6/2019: Congrats to Minh and other team members for placing 5th overall (out of 53 entries) in the TADPOLE competition

    • 6/2019: Thomas is the recipient of OHBM2019 Early Career Investigator Award

    • 6/2019: Ruby, Valeria, Csaba, Xiaolu, Jingwei & Thomas are presenting their work at OHBM2019

    • 5/2019: Our paper showing resting dynamics at different timescales is out in Nature Communications [free download]

    • 4/2019: Our paper showing that global signal regression improves RSFC-behavior associations is out in NeuroImage [pdf]

    • 4/2019: Congrats to Minh for acceptance to UC Davis PhD program

    • 4/2019: Thomas presented Alex's, Ruby's and Peng's work at Washington University, St Louis

    • 3/2019: Valeria, Ruby and Jingwei gave oral presentations of their work at the Noosa-Whistler workshop

    • 2/2019: Peter Fox and Jack Lancaster (UT San Antonio) visited our group

    • 1/2019: Simon Eickhoff (Heinrich-Heine University & Research Center Juelich) visited our group

    • 1/2019: Our neural mass model paper is out at Science Advances [free paper download] [physics world] [asian scientist]

    • 1/2019: Thomas is now an editor at eLife

    • 1/2019: Welcome Lijun An to our group!

    • 11/2018: Our paper on default network sub-specialization is out at PNAS [pdf]

    • 10/2018: Review with Simon Eickhoff & Sarah Genon on Imaging-Based Brain Parcellations is out at Nature Reviews Neuroscience [pdf]

    • 09/2018: Thomas presented Ruby's work on individual-specific cortical parcellations at RSBC

    • 09/2018: Thomas received the Singapore Neuroscience Association Young Neuroscientist Award

    • 09/2018: Welcome Angela to our group.

    • 09/2018: Our paper on connector hubs tuning modularity and optimizing behavioral performance is out at Nature Human Behavior [pdf]

    • 08/2018: Welcome Aihuiping to our group.

    • 06/2018: Welcome Shaoshi to the group.

    • 06/2018: Lucina Uddin (University of Miami), Nathan Spreng (McGill), Danilo Bzdok (RWTH Aachen) visited our group.

    • 06/2018: Congrats to He Tong for best paper award runner-up at PRNI

    • 06/2018: Our paper on individual-specific cortical networks is out at Cerebral Cortex [free download]

    • 06/2018: Thomas presented Alex's, Ruby's and Peng's work on brain parcellations and dynamics at PRNI

    • 05/2018: Our paper on mapping between MNI152/Colin27 and fsaverage is now out in HBM [pdf]

    • 05/2018: Welcome Yan Rui to our group

    • 04/2018: Congrats to Siyi for admittance into Stanford EE PhD program

    • 03/2018: Thomas presented Alex's and Ruby's work on brain parcellation at Whistler's workshop

    • 02/2018: Thomas presented Xiuming's and Nanbo's work on Alzheimer's Disease subtypes at EUROPOND 2018

    • 12/2017: Our paper on interpreting dynamic functional connectivity is out in NeuroImage [pdf]

    • 12/2017: Michael Breakspear (QIMR Berghofer) visited our group

    • 11/2017: Our paper on the diverse club is out in Nature Communications [pdf]

    • 10/2017: CM Ting (Universiti Teknologi Malaysia) visited our group

    • 08/2017: JB Poline (McGill) and Russ Poldrack (Stanford) visited our group

    • 08/2017: Welcome Valeria, Jianzhong, Xiaolu, Qing Yang, Jeremy and Alisia to our group

    • 08/2017: Thomas started his NRF fellowship on mental disorder subtypes

    • 07/2017: Our new local-global cortical parcellation is out in Cerebral Cortex [pdf]

    • 07/2017: Welcome Nicole Kuek to our group

    • 04/2017: Thomas received the NUS Young Researcher Award

    • 03/2017: Our commentary on multiscale neuroscience is out in Neuron [pdf]

    • 03/2017: Welcome Siyi Tang to our group

    • 03/2017: Lucina Uddin (University of Miami) visited our group

    • 02/2017: Congrats to Gia for admittance into Cornell ECE PhD program

    • 02/2017: Our commentary on best practices in data analysis and sharing in neuroimaging using MRI is out in Nature Neuroscience [pdf]

    • 02/2017: Tom Nichols (Warwick) visited our group

    • 11/2016: Congrats to Xilin for Rhodes Scholarship to Oxford

    • 11/2016: Itamar Kahn (Technion) visited our group

    • 10/2016: Our paper on latent atrophy factors in Alzheimer's Disease is out in PNAS [free download] [NUS press release] [MGH press release] [science daily] [upi]

    • 08/2016: Our paper on the collapsed variation Bayes inference of the author-topic model is out in PRNI [pdf]

    • 08/2016: Welcome Wenyan Hu, Tong He, Chu-Ming Chang and Csaba Orban to our team

    • 07/2016: Daniel Rueckert (Imperial College) visited our group

    • 07/2016: Commentary with Simon Eickhoff (Heinrich-Heine) is out in Nature [commentary pdf] [scientific american, huffington post, vice, popular science, geekwire]

    • 07/2016: Welcome Minh Binh Nguyen and Ke Wang to our team

    • 06/2016: Congrats to Ruby for OHBM merit abstract award

    • 06/2016: Welcome Rajan Kashyap to our team

    • 05/2016: Congrats to Ruby and Xiuming for the ISMRM educational awards

    • 05/2016: Daniel Alexander (UCL), Jonathan Polimeni (HMS), Steve Smith (Oxford) and Anastasia Yendiki (HMS) visited our group

    • 05/2016: Welcome Peng Wang and Muhammad Anwar to our team

    • 04/2016: Simon Eickhoff (Heinrich-Heine) visited our group

    • 03/2016: Suzanne Haber (University of Rochester) visited our group

    • 02/2016: Welcome Dragana Pavlovic to our team

    • 01/2016: Thomas is now editor of NeuroImage

    • 01/2016: Rodolphe Sepulchre (Cambridge) visited our group

    • 01/2016: Our paper on the genetic architecture of cortical networks is out in PNAS [pdf] [medicalxpress news]

    • 11/2015: Our paper on the modular and integrative structure of the human brain is out in PNAS [pdf] [Berkeley press release]

    • 11/2015: Welcome Raphael Liegeois to our team

    • 10/2015: Commentary with Avram Holmes (Yale) is out in Nature Neuroscience [commentary pdf] [Steve's awesome paper]

    • 08/2015: Welcome Jingwei Li, Nanbo Sun, Rensheng Liu to our team

    • 05/2015: Daniel Margulies (Max Planck) visited our group

    • 05/2015: Welcome Jianxiao Wu, Binbin Tang and Yuanhao Gong to our team

    • 03/2015: Tom Nichols (Warwick) visited our group

    • 03/2015: Congrats to Alex for being awarded the German DAAD Postdoctoral Fellowship

    • 03/2015: Our paper on predicting sleep deprivation vulnerability with functional connectivity is out in Neuroimage [pdf]

    • 02/2015: New MOE Tier 2 grant for estimating brain networks from resting-state fMRI and meta-analytic fMRI

    • 02/2015: Congrats to Xiuming for admittance into MIT EECS PhD program

    • 01/2015: Welcome Buu Vinh Tang to our team

    • 10/2014: Our meta-analysis of 10,449 imaging experiments is out in Cerebral Cortex [pdf] [interactive ontology]

    • 09/2014: New NUS Strategic Research Grant for studying memory networks in rodents and primates

    • 08/2014: Polina Golland (MIT) visited our group

    • 08/2014: Welcome Ruby Ru, Xiuming Zhang and Ngo Hoang Gia to our team

    • 07/2014: Welcome Alex Schaefer to our team