著作與專利
Publications and Patents

1. 1. 1. HC Yen, TD Oberley, S Vichitbandha, YS Ho, DK St. Clair*. The protective role of manganese superoxide dismutase against adriamycin-induced acute cardiac toxicity in transgenic mice. Journal of Clinical Investigation, 98, 1253-1260, 1996.  

      2. HC Yen, DK St. Clair*. Transgenic and knockout mice in the study of superoxide dismutases.  Journal of Biomedical and Laboratory Sciences, 9, 40-54, 1997.

      3. JN Keller, MS Kindy, FW Holtsberg, DK St. Clair, HC Yen, A Germeyer, SM Steiner, AJ Bruce-Keller, JB Hutchins, and MP Mattson*. Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduced ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction. Journal of Neuroscience, 18, 687-697, 1998.  

      4. HJ Majima, TD Oberley, K Furukawa, MP Mattson, HC Yen, LI Szweda, and DK St. Clair*. Prevention of mitochondrial injury by manganese superoxide dismutase reveals a primary mechanism for alkaline-induced cell death.  Journal of Biological Chemistry, 273, 8217-8224, 1998.

      5. P Klivenyi, DK St. Clair, M Wermer, HC Yen, TD Oberley, L Yang, and MF Beal*. Manganese superoxide dismutase overexpression attenuates MPTP-induced toxicity.  Neurobiology of Disease, 5, 253-259, 1998. 

      6. HC Yen, TD Oberley, CG Gairola, LI Szweda, and DK St. Clair*. Manganese superoxide dismutase protects mitochondrial complex I against adriamycin-induced cardiomyopathy in transgenic mice.  Archives of Biochemistry and Biophysics, 362, 59-66, 1999.

      7. W Ibrahim, US Lee, HC Yen, DK St. Clair, and CK Chow*. Antioxidant and oxidative status in tissues of manganese superoxide dismutase transgenic mice.  Free Radical Biology & Medicine, 28: 397-400, 2000.  

      8. I Trounce, J Schmiedel, HC Yen, S Hosseini, MD Brown, JJ Olsen, and DC Wallace*. Cloning of neuronal mtDNA variants in cultured cells by synaptosome fusion with mtDNA-less cells.  Nucleic Acids Research, 28, 2164-2170, 2000. 

      9. HC Yen*, HS Cheng, YT Hsu, HJ Ho, CY Nien, and YS Lee. Effects of age and health status on levels of urinary 15-F2t-isoprostane. Journal of Biomedical and Laboratory Sciences, 13: 24-28, 2001.

      10.  Y Zhao, Y Xue, TD Oberley, KK Kiningham, SM Lin, HC Yen, H Majima, J Hines and DK St. Clair*. Overexpression of MnSOD suppresses tumor formation by modulation of AP-1 signaling in a multistage skin carcinogenesis model.  Cancer Research, 61: 6082-6088, 2001. 

      11.  CK Chow, HC Yen, W Ibrahim, and DK St. Clair*. Manganese superoxide dismutase transgenic mice: characteristics and implications.  Methods in Enzymology, 353: 398-409, 2002.

      12.  HC Yen*, CY Nien, HJ Majima, CP Lee, SY Chen, JS Wei, and LC See. Increase of lipid peroxidation by cisplatin in WI38 cell but not in transformed WI38 cells. Journal of Biochemical and Molecular Toxicology, 17: 39-46, 2003.

      13.  HC Yen* and YT Hsu. Impurities from polypropylene microcentrifuge tubes as a potential source of interference in simultaneous analysis of multiple lipid-soluble antioxidants by HPLC with electrochemical detection. Clinical Chemistry and Laboratory Medicine, 42: 390-395, 2004.  

      14.  F Hirai, S Motoori, S Kakinuma, K Tomita, HP Indo, H Kato, T Yamaguchi, HC Yen, DK St. Clair, T Nagano, T Ozawa, H Saisho, and HJ Majima*. Mitochondrial signal lacking manganese superoxide dismutase failed to prevent cell death by reoxygenation following hypoxia in human pancreatic cancer cell line, KP4. Antioxidants & Redox Signaling, 6: 523-535, 2004.

      15.  HC Yen*, BS Chen, and YT Hsu.  Effect of anticoagulants and storage of coupling regent on the analysis of extracellular glutathione peroxidase in human plasma.  Journal of Biomedical and Laboratory Sciences, 16: 6-10, 2004.

      16.  HC Yen*, H-M Chang, H J Majima,, F-Y Chen, and S-H Li. Levels of reactive oxygen species and primary antioxidant enzymes in WI38 cells versus transformed WI38 cells following bleomycin treatment.  Free Radical Biology & Medicine, 38: 950-959, 2005.

      17.  HC Yen*, YC Tang, FY Chen, SW Chen, and HJ Majima. Enhancement of cisplatin-induced apoptosis and caspase 3 activation by depletion of mitochondrial DNA in a human osteosarcoma cell line. Annals of the New York Academy of Sciences, 1042: 516-522, 2005. 

      18. Y Zhao, LM Wang, L Chaiswing, HC Yen, TD Oberley, YC Lien, SM Lin, MP Mattson, DK St. Clair*. Tamoxifen protects against acute tumor necrosis factor alpha-induced cardiac injury via improving mitochondrial functions. Free Radical Biology & Medicine, 40: 1234-1241, 2006.

      19. CL Lin, YT Hsu, TK Lin, JD Morrow, JC Hsu, and TC Hsieh, PK Tsay, and HC Yen*.  Increased levels of F2-isoprostanes following aneurysmal subarachnoid hemorrhage in humans.  Free Radical Biology & Medicine, 40: 1466-1473, 2006.  

      20. HP Indo, M Davidson, HC Yen, Y Urano, S Suenaga, K Tomita, K Nishii, M Higuchi, Y Koga, T Ozawa, HJ Majima*.  Evidence of ROS generation by mitochondria in cells with impaired electron transport chain and mitochondrial DNA damage.  Mitochondrion, 7: 106-118, 2007. 

      21. BR Huang, CC Liao, WH Huang, CC Liao, WH Huang, YH Hsu, JC Hsu, HC Yen, CL Lin*. Prognostic factors of spontaneous intracerebral haemorrhage in haemodialysis patients and predictors of 30-day mortality.  Internal Medicine Journal, 38: 568-574, 2008. 

      22. JS Wang*, ML Cheng, HC Yen, BS Lou and HC Liu. Vitamin E suppresses enhancement of factor VIII-dependent thrombin generation by systemic hypoxia. Stroke, 40: 656-659, 2009.  

      23. HC Tsai, HC Yen, JC Hsu, and CL Lin*. Heparin-induced thrombocytopenia associated with intra-tumour haemorrhage in cavernous sinus after cardiac myxoma surgery.  British Journal of Neurosurgery, 23: 95-96, 2009.

      24. 謝育萍、顏秀娟*.  氧化傷害之臨床指標：Isoprostanes 和 Neuroprostanes. 生物醫學, 2：53-67, 2009.

      25. YP Hsieh, CL Lin, AL Shiue, H Yin, JD Morrow, JC Hsu, TC Hsieh, HJ Wei, HC Yen*. Correlation of F4-neuroprostanes levels in cerebrospinal fluid with outcome of aneurysmal subarachnoid hemorrhage in humans. Free Radical Biology & Medicine, 47: 814-824, 2009. 

      26. HJ Majima*, HP Indo, K Tomita, Y Iwashita, H Suzuki, D Masuda, T Shimazu, F Tanigaki, S Umemura, S Yano, K Fukui, A Higashibata, TQ Yamazaki, M Kameyama, S Suenaga, T Sato, H-C Yen, O Gusev, T Okuda, H Matsui, T Ozawa, and N Ishioka.  Bio-assessment of risk in long-term manned space exploration-cell death factors in space radiation and/or microgravity: a review.  Biological Sciences in Space, 23: 43-53, 2009.

      27. HC Yen*.  Detection of F2-isoprostanes and F4-neuroprostanes in clinical studies.  Journal of Biomedical and Laboratory Sciences, 22: 1-11, 2010. 

      28. HC Yen*, WC Hsu, CL Lin, GW Chen, YH Huang. Advantages and considerations in the confirmation of mitochondrial DNA mutations by denaturing HPLC and pyrosequencing.  Annals of the New York Academy of Sciences, 1201: 13-20, 2010.

      29. HJ Majima*, HP Indo, S Suenaga, T Kaneko, H Matsui, HC Yen, T Ozawa.  Mitochondria as source of free radicals.  Frontiers of Gastrointestinal Research, 29: 12-22, 2011.

      30. HC Yen*, SH Li, HJ Majima, YH Huang, CP Chen, YC Tu, and CW Chen. Up-regulation of antioxidant enzymes and coenzyme Q10 in a human oral cancer cell line with acquired bleomycin resistance.  Free Radical Research, 45: 707-716, 2011.

      31. HJ Majima*, HP Indo, S Suenaga, H Matsui, HC Yen, T Ozawa.  Mitochondria as possible pharmaceutical targets for the effects of vitamin E and its homologues in oxidative stress-related diseases.  Current Pharmaceutical Design, 17: 2190-2195, 2011

      32. HC Yen*, FY Chen, SW Chen, YH Huang, YR Chen, CW Chen. Effect of mitochondrial dysfunction and oxidative stress on endogenous levels of coenzyme Q10 in human cells. Journal of Biochemical and Molecular Toxicology, 25: 280-289, 2011.

      33. YK Lin, HW Chen, SH Yang, YL Leu, YH Huang, HC Yen*. Protective effect of indigo naturalis extract against oxidative stress in cultured human keratinocytes. Journal of Ethnopharmacology, 139: 893-896, 2012.

      34. HP Indo, O Inanami, T Koumura, S Suenaga, HC Yen, S. Kakinuma, KC Matsumoto, I Nakanishi, W St. Clair, DK St. Clair, H Matsui, R Cornette, O Guesev, T Okuda, Y Nakagawa, T Ozawa, HJ Majima*. Roles of mitochondria-generated reactive oxygen species on X-ray-induced apoptosis in a human hepatocellular carcinoma cell line, HLE. Free Radical Research, 46: 1029-1043, 2012.

      35. HP Indo, I Nakanishi, K Ohkubo, HC Yen, M Nyui, S Manda, KI Matsumoto, K Fukuhara, K Anzai, N Ikota, H Matsui, Y Minamiyama, A Nakajima, H Ichikawa, S Hukuzumi, T Ozawa, C Mukai, HJ Majima*. Comparison of in vivo and in vitro antioxidative parameters for eleven food factors.  RSC Advances, 3: 4535-4538, 2013.

      36. 顏秀娟*. 內生性輔酶Q之淺談. 生物醫學, 6：103-110, 2013.

      37. SW Chen, CC Liu, HC Yen*. Detection of suppressed maturation of the human COQ5 protein in the mitochondria following mitochondrial uncoupling by an antibody recognizing both precursor and mature forms of COQ5.  Mitochondrion, 13: 143-152, 2013.

      38. HC Yen*, HJ Wei, and TW Chen. Analytical variables affecting analysis of F2-isoprostanes and F4-neuroprostanes in human cerebrospinal fluids by gas chromatography/mass spectrometry. Biomedical Research International, 2013: 810915, 2013.

      39. HC Yen*, SL Li, WC Hsu, P Tang. Interference of co-amplified nuclear mitochondrial DNA sequences on the determination of human mtDNA heteroplasmy by using the SURVEYOR Nuclease and the WAVE HS system. PLOS ONE, 9: e92817, 2014.

      40. HC Yen*, CC Liu, CC, Kan, CS Chen, HR Wei. Suppression of coenzyme Q10 levels and the induction of multiple PDSS and COQ genes in human cells following oligomycin treatment.  Free Radical Research, 48: 1125-1134, 2014.

      41. HP Indo, HC Yen*, I Nakanishi, KI Matsumoto, M Tamura, Y Nagano, H Matsui, O Gusev, R Cornette, T Okuda, Y Minamiyama, H Ichikawa, S Suenaga, M Oki, T Sato, T Ozawa, DK St.Clair, HJ Majima*. A mitochondrial superoxide theory for oxidative stress diseases and aging. Journal of Clinical Biochemistry and Nutrition, 56: 1-7, 2015.

      42. HC Yen*, HJ Wei, CL Lin. Unresolved issues in the analysis of F2-isoprostanes, F4-neuroprostanes, isofurans, neurofurans, and F2-dihomo-isoprostanes in body fluids and tissue using gas chromatography/negative-ion chemical-ionization mass spectrometry. Free Radical Research, 49: 861-880, 2015.

      43. HC Kuo*, HC Yen, CC Huang, WC Hsu, HJ Wei, CL Lin. Cerebrospinal fluid biomarkers for neuropsychological symptoms in early stage of late-onset Alzheimer's disease. International Journal of Neuroscience, 125: 747-754, 2015.

      44. HC Yen, TW Chen, TC Yang, HJ Wei, JC Hsu*, CL Lin*. Levels of F2-isoprostanes, F4-neuroprostanes, and total nitrate/nitrite in plasma and cerebrospinal fluid of patients with traumatic brain injury. Free Radical Research, 49: 1419-1430, 2015.

      45. HJ Majima*, HP Indo, I Nakanishi, S Suenaga, K Matsumoto, H Matsui, Y Minamiyama, H Ichikawa, HC Yen, CL Hawkins, MJ Davies, T Ozawa, DK St. Clair. Chasing great paths of Helmut Sies “Oxidative Stress”. Archives of Biochemistry and Biophysics, 595, 54-60, 2016.

      46. HC Yen*, YC Liu, CC Kan, HJ Wei, SH Lee, YH Wei, YH Feng, CW Chen, CC Huang. Disruption of the human COQ5-containing protein complex is associated with diminished coenzyme Q10 levels under two different conditions of mitochondrial energy deficiency. Biochimica et Biophysica Acta-General Subjects, 1860: 1864-1876, 2016.

      47. HC Yen*, CL Lin, BS Chen, CW Chen, KC Wei, ML Yang, JC Hsu, YH Hsu. Alterations of the levels of primary antioxidant enzymes in different grades of human astrocytoma tissues. Free Radical Research, 52: 856-871, 2018.  

      48. HC Yen*, WY Yeh, SH Lee, YH Feng, SL Yang. Characterization of human mitochondrial PDSS and COQ proteins and their roles in maintaining coenzyme Q10 levels and each other’s stability. Biochim Biophys Acta-Bioenergetics, 1861:148192, 2020.

      49. HC Yen*, BS Chen, SL Yang, SY Wu, CW Chang, KC Wei, JC Hsu, YH Hsu, TH Yen, CL Lin*. Levels of coenzyme Q10 and several COQ proteins in human astrocytoma tissues are inversely correlated with malignancy. Biomolecules, 12: 336, 2022.

      50. TH Yen, CW Chang, HR Tsai, JF Fu, HC Yen*. Immunosuppressive therapies attenuate paraquat-induced renal dysfunction by suppressing inflammatory responses and lipid peroxidation. Free Radical Biology and Medicine, 191: 249-260, 2022.                           

      51. M Kotepui*, K Kotepui, A Mahittikorn*, HJ Majima, J Tangpong, HC Yen. Association of reduced glutathione levels with Plasmodium falciparum and Plasmodium vivax malaria: a systematic review and meta‑analysis. Scientific Reports, 13: 14683, 2023.

      52. D Masuda, I Nakanishi*, K Ohkubo, H Ito, K Matsumoto, H Ichikawa, M Chatatikun, WK Klangbud, M Kotepui, M Imai, F Kawakami, M Kubo, H Matsui, J Tangpong, T Ichikawa, T Ozawa, HC Yen, DK St. Clair, HP Indo*, HJ Majima*. Mitochondria play essential roles in intracellular protection against oxidative stress—Which molecules among the ROS generated in the mitochondria can escape the mitochondria and contribute to signal activation in cytosol? Biomolecules, 14: 128, 2024.

      53. HC Yen*, CT Hsu, SY Wu, CC Kan, CW Chang, HM Chang, YA Chien, YH Wei, CY Wu. Alterations in coenzyme Q10 status in a cybrid line harboring the 3243A>G mutation of mitochondrial DNA is associated with abnormal mitochondrial bioenergetics and dysregulated mitochondrial biogenesis. Biochimica et Biophysica Acta - Bioenergetics, 1864: 149492, 2024.

                       * Corresponding author

H J Majima, H P Indo, K Tomita, S Suenaga, S Motoori, H Kato, H-C Yen, and T Ozawa.  Intracellular oxidative stress caused by ionizing radiation.  Chapter 2 in : K Singh eds. Oxidative stress, disease, and cancer.  London,: Imperial College Press; 2005 (ISBN: 1-86094-609-7).