Neural tube organoids

The first fully patterned human neural orgnaoids that models key developmental aspects of both brain and spinal cord.

Neural tube organoid

Formation of a single lumen in the stem cell-derived neural tube organoids.

Rostral-caudal and dorsal-ventral patterning of neural tube organoids

Neural crest migration 

Neural crest cells delaminate from dorsal region of neural tube organoids and migrate as single cells. Green color indicates progenies of neuromesodermal progenitor cells. 

Dorsal-ventral patterned human forebrain organoids

Three dimensional reconstruction of dorsal-ventral patterned human forebrain organoids on day 40, stained for cortical marker CTIP2 and MGE marker NKX2-1.

Microbubble oscillation

Oscillation of microbubbles attached to human embryonic stem cell colonies during ultrasound stimulation.