We are hiring! We are looking for motivated individuals to join us as research assistants, rotation students, and postdoctoral fellows. If you are interested, please send your inquiry along with your CV to Dr. Xufeng Xue at xufeng.xue@cchmc.org.
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Our goal is to create miniature human organs using stem cells to unravel disease mechanism, improve drug development, and advance personalized regenerative medicine. Specifically, we develop various bioengineering techniques, such as microfluidics, 3D bioprinting, optogenetics, cell mechanics tools, and synthetic biology to guide stem cell pattern formation and morphogenesis to build next generation human organoids with high reproducibility, complexity and fidelity. Please read our Research for details.
Selected publications
Selected publications
Cultivating advanced embryo models through bioengineering mastery
Xufeng Xue, Yue Liu, and Jianping Fu
Nature Reviews Bioengineering, 2024, in press
A human pluripotent stem cell-based somitogenesis model using microfluidics
Yue Liu, Yung Su Kim, Xufeng Xue, Norio Kobayashi, Shiyu Sun, Qiong Yang, Olivier Pourquié, and Jianping Fu
Cell Stem Cell, 2024. Accepted
DOI: 10.1101/2023.10.29.564399
A patterned human neural tube model using microfluidic gradients
Xufeng Xue, Yung Su Kim, Alfredo-Isaac Ponce-Arias, Richard O'Laughlin, Robin Zhexuan Yan, Norio Kobayashi, Rami Yair Tshuva, Yu-Hwai Tsai, Shiyu Sun, Yi Zheng, Yue Liu, Frederick C.K. Wong, Azim Surani, Jason Spence, Hongjun Song, Guo-Li Ming, Orly Reiner, and Jianping Fu
Nature, vol. 628, 391-399, 2024
DOI: 10.1038/s41586-024-07204-7
Mechanical Tension Promotes Formation of Gastrulation-like Nodes and Patterns Mesoderm Specification in Human Embryonic Stem Cells
Jonathon Muncie, Nadia Ayad, Johnathon Lakins, Xufeng Xue, Jianping Fu, Valerie Weaver
Developmental Cell, vol. 55, pp. 679-694, 2020
DOI: 10.1016/j.devcel.2020.10.015
Dorsal-ventral patterned neural cyst from human pluripotent stem cells in a biomimetic neurogenic niche
Yuanyuan Zheng#, Xufeng Xue#, Agnes M. Resto-Irizarry, Zida Li, Yue Shao, Yi Zheng, Gang Zhao, and Jianping Fu
Science Advances, vol. 5, eaax5933, 2019
Controlled modeling of human epiblast and amnion development using stem cells.
Yi Zheng, Xufeng Xue, Yue Shao, Sicong Wang, Sajedeh Nasr Esfahani, Zida Li, Jonathon Muncie, Johnathon N. Lakins, Valerie M. Weaver, Deborah L. Gumucio, and Jianping Fu
Nature, vol. 573, pp. 421-425, 2019
DOI: 10.1038/s41586-019-1535-2
Mechanics-guided embryonic patterning of neuroectoderm tissue from human pluripotent stem cells
Xufeng Xue#, Yubing Sun#, Agnes M. Resto-Irizarry, Ye Yuan, Koh Meng Aw Yong, Yi Zheng, Shinuo Weng, Yue Shao, Yimin Chai, Lorenz Studer, and Jianping Fu
Nature Materials, vol. 17, pp. 633-641, 2018
The first fully patterned human neural orgnaoids that models key developmental aspects of both brain and spinal cord.
ZsGreen+ neural crest cells delaminate from the dorsal region of neural tube organoids and migrate as single cells.
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