Besides all its other performance-improvements, Rocketman has a system to cache RimWorld's Defs & mod-patches. Without going into too much detail, usually at startup RimWorld is throwing together all Defs from the basegame and mods into one big database-file and then runs all mod-patches (in addition to more complicated things) against it. The result of this process is then used by the game as blueprint for basically every 'item' ingame.
Depending on the mod-count and how patch-heavy a certain modlist is, this can take up a significant amount of time, thus prolongs the startup process of the game. Rocketman makes a copy of the endresult of said process and is then directly saving it to your drive, so for each successive start of the game it only has to load that file into memory and can basically bypass the rest of the process resulting in various degrees of reduced loadtimes.
Whenever mods update though, this means that sticking to that cached file would result in issues. For that reason Rocketman has different ways of detecting significant mod-changes that cause it to flush the old file if necessary and to rebuild it. This also happens by default every few days, just to prevent issues. At times though something can go wrong; Rocketman not realizing that it has to flush the cache, the cache-file getting corrupted, etc. If you're affected by such a case, haven't played the game in a long time, just want to make sure to start from a clean-slate, being instructed by a troubleshooter to do so - whatever the reason, this is the (very simple) way to flush the cache by hand.
All you have to do is to delete the relevant files in your user-folder - or better; delete the whole Cache-folder. There's no important data that can be lost in those files, so completely deleting it is typically perfectly safe and will only result in the game having to rebuild the cache-file the next time you start the game.
If you're unable to locate the folder, make sure you know how to navigate into the (hidden, on Windows) AppData folder to begin with or ask your resident troubleshooter when in doubt.
Cache-folder location:
%USERPROFILE%\AppData\LocalLow\Ludeon Studios\RimWorld by Ludeon Studios\RocketMan\Cache