• Computational intrepretation of dopaminergic cell loss in Parkinson's disease

         - Gutamate-induced toxicity (Excitotoxicity) caused by subthalamic nucleus in substantia nigra pars compacta.

         - Levodopa-induced toxicity (Dopamine oxidation) caused by levodopa therapy in substantia nigra pars compacta.

• Modeling chronic levodopa treatment consequences and motor dysfunctions in Parkinson's disease

         - Wearing-off phenomenon (predictable motor fluctuations).

         - On-off phenomenon (unpredictable motor fluctuations).

         - Levodopa-induced dyskinesias.

• Developing a therapeutic test-bench for Parkinson's disease

• Developing a canonical model of basal ganglia