Publications

Journal Articles

Stavros I. Dimitriadis, Vignayanandam R. Muddapu, Roberto Guidotti (2024) Editorial: Reproducible analysis in neuroscience, Frontiers in Neuroinformatics 18:1520012.
Sandeep S. Nair, Vignayanandam R. Muddapu, Vigneswaran Chandrasekaran, Pragathi Priyadharsini Balasubramani, Jyoti Mishra, Dhakshin S. Ramanathan, V. Srinivasa Chakravarthy (2023) A Generalized Reinforcement Learning-Based Deep Neural Network (GRL-DNN) Agent Model for Diverse Cognitive Constructs, Scientific Reports 13, 5928. ModelDB
Elisabetta Iavarone, Jane Simko, Ying Shi, Marine Bertschy, María García-Amado, Polina Litvak, Anna-Kristin Kaufmann, Christian O’Reilly, Oren Amsalem, Marwan Abdellah, Grigori Chevtchenko, Benoît Coste, Jean-Denis Courcol, András Ecker, Cyrille Favreau, Adrien Christian Fleury, Werner Van Geit, Michael Gevaert, Nadir Román Guerrero, Joni Herttuainen, Genrich Ivaska, Samuel Kerrien, James G. King, Pramod Kumbhar, Patrycja Lurie, Ioannis Magkanaris, Vignayanandam R. Muddapu, Jayakrishnan Nair, Fernando L. Pereira, Rodrigo Perin, Fabien Petitjean, Rajnish Ranjan, Michael Reimann, Liviu Soltuzu, Mohameth François Sy, M. Anıl Tuncel, Alexander Ulbrich, Matthias Wolf, Francisco Clascá, Henry Markram, & Sean L. Hill (2023) Thalamic Control of Sensory Processing and Spindles in a Biophysical Somatosensory Thalamoreticular Circuit Model of Wakefulness and Sleep, Cell Reports. Thalamoreticular Microcircuit Portal
Vignayanandam R. Muddapu, Karthik Vijayakumar, Keerthiga Ramakrishnan, & V. Srinivasa Chakravarthy (2022) A Multi-Scale Computational Model of Levodopa-Induced Toxicity in Parkinson's Disease, Frontiers in Neuroscience. ModelDB
Sandeep S. Nair, Vignayanandam R. Muddapu & V. Srinivasa Chakravarthy (2022) A Multiscale, Systems-level, Neuropharmacological Model of Cortico-Basal Ganglia System for Arm Reaching under Normal, Parkinsonian and Levodopa Medication Conditions, Frontiers in Computational Neuroscience. ModelDB
Vignayanandam R. Muddapu, & V. Srinivasa Chakravarthy (2021) Influence of Energy Deficiency on the Subcellular Processes of Substantia Nigra Pars Compacta Cell for Understanding Parkinsonian Neurodegeneration, Scientific Reports 11, 1754. ModelDB
Vignayanandam R. Muddapu, & V. Srinivasa Chakravarthy (2020) A Multi-Scale Computational Model of Excitotoxic Loss of Dopaminergic Cells in Parkinson’s Disease, Frontiers in Neuroinformatics. ModelDB
Vignayanandam R. Muddapu, S. Akila P. Dharshini, V. Srinivasa Chakravarthy, M. Michael Gromiha (2020) Neurodegenerative diseases -Is metabolic deficiency the root cause?, Frontiers in Neuroscience| Neurodegeneration.
Vignayanandam R. Muddapu, Alekhya Mandali, V. Srinivasa Chakravarthy, Srikanth Ramaswamy (2019) A Computational Model of Loss of Dopaminergic Cells in Parkinson’s Disease Due to Glutamate-Induced Excitotoxicity, Frontiers in Neural Circuits. ModelDB

Patent

V. Srinivasa Chakravarthy, Vignayanandam R. Muddapu, & Sandeep S. Nair (2024) Multiscale Systems Neuropharmacological Model of Cortico-Basal Ganglia Circuitry of Reaching For Normal And Parkinson’s Disease, (India Patent # 518500: Granted in 2024).

Book Chapter

Sandeep S. Nair, Vignayanandam R.J. Muddapu, Meghna Sriram, Aditya R., Reema Gupta, V. Srinivasa Chakravarthy (2022) Is There a Better Way to Assess Parkinsonian Motor Symptoms?—Experimental and Modelling Approach. In: Arjunan S.P., Kumar D.K. (eds) Techniques for Assessment of Parkinsonism for Diagnosis and Rehabilitation. Series in BioEngineering. Springer, Singapore.

Conference Proceedings

Vignayanandam R. Muddapu, Alexander Kozlov, Alexis Arnaudon, Johannes J.J. Hjorth, Vishal Sood, Henry Markram, Jeanette H. Kotaleski, & Armando Romani, Multiscale Data Integration to Generate Atlas-Based Biophysical Modeling of Mouse Striatal Nuclei, In Society for Neuroscience 2024 (SfN-2024) which was held in Chicago, USA during 5-9 October, 2024.
Austin E. Soplata, Elisabetta Iavarone, Polina Litvak, Hugo Dictus, Vignayanandam R. Muddapu, Armando Romani, Henry Markram, & Sean L. Hill, Multiscale Data Integration to Generate Atlas-Based Biophysical Modeling of First- and Higher-Order Mouse Thalamic Nuclei, In Society for Neuroscience 2023 (SfN-2023) which was held in Washington, D.C., USA during 11-15 November, 2023.
Sandeep S. Nair, Vignayanandam R. Muddapu & V. Srinivasa Chakravarthy (2021) A Multiscale Computational Model of Levodopa Medication Effect on Arm Reaching in Parkinson's Disease, Bernstein Conference 2021.
Sandeep S. Nair, Vignayanandam R. Muddapu & V. Srinivasa Chakravarthy, Differential dopaminergic axonal degeneration manifest into tremor-like and rigidity-like Parkinsonian symptoms: A computational investigation, Society for Neuroscience (SfN) Global Connectome 2020 (Virtual), January 11 - 13, 2021.
Sandeep S. Nair, Vignayanandam R. Muddapu & V. Srinivasa Chakravarthy, A Multiscale Cortico-Basal Ganglia Model for Arm Reaching Task in Normal and Parkinsonian Conditions, Neuromatch 3.0 (virtual), October 26 - 30, 2020 (Accepted for traditional talk).
Vignayanandam R. Muddapu, Pragathi Priyadharsini Balasubramani, Jyoti Mishra, Dhakshin S. Ramanathan , V. Srinivasa Chakravarthy (2020) A Generalized Reinforcement Learning-Based Deep Neural Network Model for Diverse Cognitive Constructs. Bernstein Conference 2020.
Vignayanandam R. Muddapu, Abhinav Sardana, & V. Srinivasa Chakravarthy Loss of Projection Neurons Due to Glutamate Toxicity in Alzheimer’s Disease: A Computational Model, Advances in Alzheimer’s and Parkinson’s Therapies 2020 (AD-PD 2020) to be held in Vienna, Austria.
Vignayanandam R. Muddapu, Karthik Vijayakumar, Keerthiga Ramakrishnan, & V. Srinivasa Chakravarthy A Computational Model of Levodopa-Induced Toxicity in Substantia Nigra Pars Compacta in Parkinson's Disease, Dopamine 2020 to be held in Montreal, Canada.
Sandeep Nair, Vignayanandam R. Muddapu, & V. Srinivasa Chakravarthy A Systems Neuropharmacological Model of Cortico-Basal Ganglia Circuitry of Arm Reaching for Normal, Parkinsonian and Levodopa medication, Annual Conference of Neural Control of Movement 2020 to be held in Dubrovnik, Croatia.
Vishant Batta, Vignayanandam R. Muddapu, Sandeep Nair, & V. Srinivasa Chakravarthy A Computational Pharmacological Model of Levodopa Medication of PD Patients, ACCS, BITS-Pilani Goa, India, 2019.
Kratika Mujmer, Sandeep Nair, Vignayanandam R. Muddapu & V. Srinivasa Chakravarthy, Role of Astrocytes in Metabolic Support of Neurons, ACCS, BITS-Pilani Goa, India, 2019.
Vignayanandam R. Muddapu, V. Srinivasa Chakravarthy, A Comprehensive Biophysical Model of Substantia Nigra Pars compacta Cells for Understanding Parkinsonian Neurodegeneration, SfN, Chicago, USA, 2019.
Vignayanandam R. Muddapu, Srinivasa V. Chakravarthy, Programmed Cell Death in Substantia Nigra Due to Subthalamic Nucleus- Mediated Excitotoxicity: A Computational Model of Parkinsonian Neurodegeneration, OCNS, Antwerp, Belgium, 2017 Extended abstract Poster
Pragathi P. Balasubramani, V. Srinivasa Chakravarthy & Vignayanandam R. Muddapu, A Simple Computational Model of Altered Neuromodulation in Cortico-Basal Ganglia Dynamics Underlying Bipolar Oscillations, Organization of Computational Neuroscience (OCNS) , Antwerp, Belgium, 2017 Extended abstract Poster

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