2023-2025 (CD133DIAG)

In collaboration with Dr Emilie Roeder, Nancyclotep, Nancy

Just starting ! :) 

2021-2023 (IMAFIBRO)

In collaboration with Dr Pierre-Simon Bellaye, CGFL, Dijon

In this project, we synthesized the first nuclear imaging tracer targeting LOXL2, an enzyme expressed during fibrosis. This tracer was evaluated by SPECT-CT in a mouse model of progressive pulmonary fibrosis 

We are currently exploring this target in other indications.

2017-2022 (JCJC - ZINELABEL)

ZINELABEL explored the chemistry of dichlorotetrazine, a minimalist chemical platform allowing the site-specific introduction two payloads/imaging probes on a single protein residue. This platform has now been applied to the synthesis of numerous bioconjugates.

2017-2018 (FLUOnTEP)

In collaboration with Dr Aurélie Prignon, Sorbonne Université, Paris

Here, we designed peptide-based bimodal PET (68Ga) - fluorescent tracers targeting neurotensin receptor 1 (NTS1). These tracers were evaluated in a mice model of pancreatic cancer (PDAC, AsPC1 xenograft). The project was extended with the radiolabeling of small molecule antagonists of NTS1.