Publications
Research papers
32 - Moving beyond isothiocyanates: A look at the stability of conjugation links towards radiolysis in 89Zr-labeled immunoconjugates.
R. Vizier, P. Adumeau, M. Moreau, V. Goncalves, F. Denat
Bioconjugate Chemistry (2024), 35, 633–637
D. Vivier, M. Hautière, D. Pineau, PA. Dancer, A. Herbet, JP. Hugnot, C. Bernhard, V. Goncalves, C. Truillet, D. Boquet, F. Denat
Bioconjugate Chemistry (2023), 34, 2144-2153
30 - SPECT Imaging of Lysyl Oxidase-like 2 in a Model of Idiopathic Pulmonary Fibrosis.
R. Vizier, AR. Garnier, A. Dias, M. Moreau, M. Claron, B. Collin, F. Denat, PS. Bellaye, V. Goncalves.
Molecular Pharmaceutics (2023), 20, 3613-3622.
M. Hautiere, D. Vivier, D. Pineau, C. Denis, D. Kereselidze, A. Herbet, N. Costa, V. Goncalves, E. Selingue, B. Larrat, JP. Hugnot, F. Denat, D. Boquet, C. Truillet.
European Journal of Nuclear Medicine and Molecular Imaging (2023), 50, 3192-3201
28 - Modular One-Pot Strategy for the Synthesis of Heterobivalent Tracers.
T. Bailly, S. Bodin, V. Goncalves, F. Denat, C. Morgat, A. Prignon, IE Valverde
ACS Medicinal Chemistry Letters (2023), 14, 636-644
27 - Site-Specific, Platform-Based Conjugation Strategy for the Synthesis of Dual-Labeled Immunoconjugates for Bimodal PET/NIRF Imaging of HER2-Positive Tumors
P. Adumeau, R. Raavé, M. Boswinkel, S. Heskamp, H.J.C.T. Wessels, A.J. van Gool, M. Moreau, C. Bernhard, L. Da Costa, V. Goncalves, F. Denat
Bioconjugate Chemistry (2022), 33, 3, 530–540
26 - Positron Emission Tomography Imaging of Neurotensin Receptor-Positive Tumors with 68Ga-Labeled Antagonists: The Chelate Makes the Difference Again
E. Renard, M. Moreau, P.-S. Bellaye, M. Guillemin, B. Collin, A. Prignon, F. Denat, V. Goncalves
Journal of Medicinal Chemistry (2021), 64, 8564–8578
25 - Site-Specific Dual-Labeling of a VHH with a Chelator and a Photosensitizer for Nuclear Imaging and Targeted Photodynamic Therapy of EGFR-Positive Tumors
E. Renard, E. Collado Camps, C. Canovas, A. Kip, M. Gotthardt, M. Rijpkema, F. Denat, V. Goncalves, S.A.M. van Lith
Cancers (2021), 13, 428
24 - Design of Bimodal Ligands of Neurotensin Receptor 1 for PET Imaging and Fluorescence-Guided Surgery of Pancreatic Cancer
E. Renard, P.A. Dancer, C. Portal, F. Denat, A. Prignon, V. Goncalves
Journal of Medicinal Chemistry (2020), 63, 2426-2433
23 - Synthesis and evaluation of zirconium-89 labelled and long-lived GLP-1 receptor agonists for PET imaging
C.B. Jacobsen, R. Raavé, M.O. Pedersen, P. Adumeau, M. Moreau, I.E. Valverde, I. Bjørnsdottir, J.B. Kristensen, M.F. Grove, K. Raun, J. McGuire, V. Goncalves, S. Heskamp, F. Denat, M. Gustafsson
Nuclear Medicine and Biology (2020), 82-83, 49-56
22 - Direct comparison of the in vitro and in vivo stability of DFO, DFO* and DFOcyclo* for 89Zr-immunoPET
R. Raavé, G. Sandker, P. Adumeau, C. Borch Jacobsen, F. Mangin, M. Meyer, M. Moreau, C. Bernhard, L. Da Costa, A. Dubois, V. Goncalves, M. Gustafsson, M. Rijpkema, O. Boerman, J.-C. Chambron, S. Heskamp, F. Denat
European Journal of Nuclear Medicine and Molecular Imaging (2019), 46, 1966-1977
21 - Modular assembly of multimodal imaging agents through an inverse electron demand Diels-Alder reaction
C. Canovas, M. Moreau, J.-M. Vrigneaud, P.-S.Bellaye, B. Collin, F. Denat, V. Goncalves
Bioconjugate Chemistry (2019), 30, 888-897
20 - Site-Specific Near-Infrared Fluorescent Labelling of Proteins on Cysteine Residues with meso-Chloro-Substituted Heptamethine Cyanine Dyes
C. Canovas, P.-S. Bellaye, M. Moreau, A. Romieu, F. Denat, V. Goncalves
Organic & Biomolecular Chemistry (2018), 16, 8831-8836
19 - Site-Specific Dual-Labeling of Proteins on Cysteine Residues with Chlorotetrazines.
C. Canovas, M. Moreau, C. Bernhard, A. Oudot, M. Guillemin, F. Denat, V. Goncalves
Angewandte Chemie International Edition (2018), 57, 10646-10650
18 - 89Zr-immunoPET in oncology: state of the art 89Zr-radiochemistry.
S. Heskamp, R. Raavé, O.C. Boerman, M. Rijpkema, V. Goncalves, F. Denat
Bioconjugate Chemistry (2017), 28, 2211-2223
17 - Structure-guided optimization of quinoline inhibitors of Plasmodium N- myristoyltransferase
V. Goncalves, J. A. Brannigan, A. Laporte, A. S. Bell, S. M. Roberts, A. J. Wilkinson, R. J. Leatherbarrow, E. W. Tate
MedChemComm (2017), 8, 191-197
16 - Direct subphthalocyanine conjugation to bombesin vs indirect conjugation to its lipidic nanocarrier
Y. Bernhard, E. Gigot, V. Goncalves, M. Moreau, N. Sok, P. Richard, R.A. Decréau
Organic & Biomolecular Chemistry (2016), 14 (19), 4511-4518
15 - (R)-NODAGA-PSMA: A Versatile Precursor for Radiometal Labeling and Nuclear Imaging of PSMA-Positive Tumors
E. Gourni, C. Canovas, V. Goncalves, F. Denat, P.T. Meyer, H.R. Maecke
PLoS One (2015), 10 (12), e0145755
14 - BODIPY-polyazamacrocycles as bimodal probes for molecular imaging
D. Lhenry, M. Larrouy, C. Bernhard, V. Goncalves, O. Raguin,P. Florent,M. Moreau,B. Collin,A. Oudot, J-M.Vrigneaud,F. Brunotte,C. Goze, F. Denat
Chemistry - A European Journal (2015), 21 (37), 13091-13099.
13 - MA-NOTMP: a triazacyclononane-trimethylphosphinate based bifunctional chelator for gallium-radiolabelling of biomolecules
S. Poty, P. Désogère, J. Šimeček, C. Bernhard, V. Goncalves, C. Goze, F. Boschetti, J. Notni, H.J. Wester, F. Denat
ChemMedChem (2015), 10, 1475-1479.
12 - Towards the elaboration of new gold-based optical theranostics
P-E. Doulain, R. Decréau, C. Racoeur, V. Goncalves, L. Dubrez, A. Bettaieb, P. Le Gendre, F. Denat, C. Paul, C. Goze, E. Bodio.
Dalton Transactions (2015), 44 (11), 4874-4883
11 - DMAP-BODIPY Alkynes: A Convenient Tool for Labeling Biomolecules for Bimodal PET–Optical Imaging
B. Brizet, V. Goncalves, C. Bernhard, P. D. Harvey, F. Denat, C. Goze.
Chemistry - A European Journal (2014), 20 (40), 12933-12944
10 - Structure-based design of potent and selective Leishmania N-myristoyltransferase inhibitors
J.A. Hutton, V. Goncalves, J.A. Brannigan, D. Paape, M.H. Wright, T.M. Waugh, S.M. Roberts A.S. Bell, A.J. Wilkinson, D.F. Smith, R.J. Leatherbarrow, E.W. Tate.
Journal of Medicinal Chemistry (2014), 57 (20), 8664-8670
09 - Discovery of Plasmodium vivax N-myristoyltransferase inhibitors: Screening, synthesis, and structural characterization of their binding mode
V. Goncalves, J.A. Brannigan, D. Whalley, B. Saxty, A.A. Holder, A.J. Wilkinson, E.W. Tate, R.J. Leatherbarrow.
Journal of Medicinal Chemistry (2012), 55 (7), 3578-3582
08 - A fluorescence-based assay for N-myristoyltransferase activity.
V. Goncalves, J.A. Brannigan, E. Thinon, T.O. Olaleye, R. Serwa, S. Lanzarone, A.J. Wilkinson, E.W. Tate, R.J. Leatherbarrow
Analytical Biochemistry (2012), 421 (1), 342-344
07 - Targeting the pro-angiogenic VEGF-VEGFR protein-protein interface with drug-like compounds by in silico and in vitro screening
B. Gautier, M.A. Miteva, V. Goncalves, F. Huguenot, C. Garbay, A. Lesnard, S. Rault, N. Inguimbert, Bruno O. Villoutreix, Michel Vidal
Chemistry & Biology (2011), 18 (12), 1631-1639
06 - Biochemical and structural analysis of the binding determinants of a vascular endothelial growth factor receptor peptidic antagonist
B. Gautier, V. Goncalves, D. Diana, R. Di Stasi, F. Teillet, C. Lenoir, F. Huguenot, C. Garbay, R. Fattorusso, L. Domenico D'Andrea, M. Vidal, N. Inguimbert.
Journal of Medicinal Chemistry (2010), 53, 11, 4428-4440
05 - Total chemical synthesis of the D2 domain of human VEGF receptor 1
V. Goncalves, B. Gautier, F. Huguenot, P. Leproux, C. Garbay, M. Vidal, N. Inguimbert.
Journal of Peptide Science (2009), 15 (6), 417-422
04 - Structure-based design of a bicyclic peptide antagonist of the Vascular Endothelial Growth Factor Receptors
V. Goncalves, B. Gautier, C. Garbay, M. Vidal, N. Inguimbert.
Journal of Peptide Science (2008), 14 (6), 767-772
03 - On-resin cyclization of peptide ligands of the Vascular Endothelial Growth Factor Receptor 1 by copper(I)-catalyzed 1,3-dipolar azide-alkyne cycloaddition
V. Goncalves, B. Gautier, A. Regazzetti, P. Coric, S. Bouaziz, C. Garbay, M. Vidal, N. Inguimbert.
Bioorganic and Medicinal Chemistry Letters (2007), 17, 5590-5594
02 - Rational design, structure and biological evaluation of cyclic peptides mimicking the Vascular Endothelial Growth Factor
V. Goncalves, B. Gautier, P. Coric, S. Bouaziz, C. Lenoir, C. Garbay, M. Vidal, N. Inguimbert.
Journal of Medicinal Chemistry (2007), 50 (21), 5135-5146
01 - Development of a chemiluminescent screening assay for Vascular Endothelial Growth Factor Receptor 1 ligands
V. Goncalves, B. Gautier, C. Garbay, M. Vidal, N. Inguimbert.
Analytical Biochemistry (2007), 366 (1), 108-110
Patents
Plateforme tétrazine modulaire biocompatible - Victor Goncalves, Franck Denat, Claire Bernhard, Coline Canovas
FR 17 52451, FR 17 59851, PCT/EP2018/057520, WO2018172543A1