Publications 

A Giblin,  AJ Cammack, N Blomberg, A Mikheenko, M Carcolé, R Coneys, L Zhou, Y Mohammed, D Olivier-Jimenez,  ML Atilano,  VT Niccoli, AN Coyne,  R van der Kant,  T Lashley,  M Giera, L Partridge,  AM Isaacs. Neuronal polyunsaturated fatty acids are protective in FTD/ALS. BioRxiv. doi: https://doi.org/10.1101/2024.01.16.575677

Feringa, F.M., Van Der Kant, R. An inside job: New roles for ApoE at the lipid droplet. J Cell Biol 2024 Apr 1;223(4):e202402171. 

Kloske CM, Barnum CJ, Batista AF... Carrillo MC (2023). APOE and immunity: Research highlights. Alzheimers Dementia. 2023 Jun;19(6):2677-2696

Mishra, S., Van Deursen, C., Robert, A., Van Der Kant, R., & Young, J. E. (2023). Advantages and limitations of hiPSC-derived neurons for the study of neurodegeneration. In Phenotyping of Human iPSC-derived Neurons (pp. 243-261). Academic Press. 

Pantazis, C. B., Yang, A., Lara, E., McDonough, J. A., Blauwendraat, C., Peng, L., ... & Merkle, F. T. (2022). A reference human induced pluripotent stem cell line for large-scale collaborative studies. Cell Stem Cell, 29(12), 1685-1702. 

Ossenkoppele, R., van der Kant, R., & Hansson, O. (2022). Tau biomarkers in Alzheimer's disease: towards implementation in clinical practice and trials. The Lancet Neurology. 

Frisoni, G. B., Altomare, D., Thal, D. R., Ribaldi, F., van der Kant, R., Ossenkoppele, R., ... & Dubois, B. (2022). The probabilistic model of Alzheimer disease: the amyloid hypothesis revised. Nature Reviews Neuroscience, 23(1), 53-66. 

Feringa, F. M., & Van der Kant, R. (2021). Cholesterol and Alzheimer’s disease; from risk genes to pathological effects. Frontiers in Aging Neuroscience, 13, 690372. 

Langness, V. F., Van der Kant, R., Das, U., Wang, L., Chaves, R. D. S., & Goldstein, L. S. (2021). Cholesterol-lowering drugs reduce APP processing to Aβ by inducing APP dimerization. Molecular Biology of the Cell, 32(3), 247-259. 

Jongsma, M. L., Bakker, J., Cabukusta, B., Liv, N., van Elsland, D., Fermie, J., ... & Neefjes, J. (2020). SKIP‐HOPS recruits TBC 1D15 for a Rab7‐to‐Arl8b identity switch to control late endosome transport. The EMBO journal, 39(6), e102301. 

van der Kant, R., Goldstein, L. S., & Ossenkoppele, R. (2020). Amyloid-β-independent regulators of tau pathology in Alzheimer disease. Nature Reviews Neuroscience, 21(1), 21-35. 

van der Kant, R., Langness, V. F., Herrera, C. M., Williams, D. A., Fong, L. K., Leestemaker, Y., ... & Goldstein, L. S. (2019). Cholesterol metabolism is a druggable axis that independently regulates tau and amyloid-β in iPSC-derived Alzheimer’s disease neurons. Cell stem cell, 24(3), 363-375. 

In the news:

https://www.alzforum.org/news/research-news/cholesteryl-esters-hobble-proteasomes-increase-p-tau (Alzforum post)
https://pubmed.ncbi.nlm.nih.gov/30849361/ (News and Views)

https://www.telegraaf.nl/nieuws/3152727/cholesterolremmers-helpen-tegen-alzheimer (Dutch news outlet)
https://www.rtlnieuws.nl/nieuws/nederland/artikel/4609246/mogelijk-verband-tussen-cholesterol-en-alzheimer  (Dutch news outlet)

Woodruff, G., Reyna, S. M., Dunlap, M., Van Der Kant, R., Callender, J. A., Young, J. E., ... & Goldstein, L. S. (2016). Defective transcytosis of APP and lipoproteins in human iPSC-derived neurons with familial Alzheimer’s disease mutations. Cell reports, 17(3), 759-773. 

Van Der Kant, R., Jonker, C. T., Wijdeven, R. H., Bakker, J., Janssen, L., Klumperman, J., & Neefjes, J. (2015). Characterization of the mammalian CORVET and HOPS complexes and their modular restructuring for endosome specificity. Journal of Biological Chemistry, 290(51), 30280-30290. 

Van Der Kant, R., & Goldstein, L. S. (2015). Cellular functions of the amyloid precursor protein from development to dementia. Developmental cell, 32(4), 502-515. 

van der Kant, R., & Neefjes, J. (2014). Small regulators, major consequences–Ca2+ and cholesterol at the endosome–ER interface. Journal of cell science, 127(5), 929-938. 

Neefjes, J., & van der Kant, R. (2014). Stuck in traffic: an emerging theme in diseases of the nervous system. Trends in neurosciences, 37(2), 66-76. 

van der Kant, R., Fish, A., Janssen, L., Janssen, H., Krom, S., Ho, N., ... & Neefjes, J. (2013). Late endosomal transport and tethering are coupled processes controlled by RILP and the cholesterol sensor ORP1L. Journal of cell science, 126(15), 3462-3474.