Publications 

Carla Cuní-López, Jessica T. Root, Ying Hao, Niek Blomberg, Sascha J. Koppes-den Hertog, Dylan Sacks, Amber E. Trujillo,Rodolfo Ghirlando, Isabelle Kowal, Jacob Epstein, Linda G. Yang,

Mark R. Cookson, Elise Marsa, Rik van der Kant, Martin Giera, Yue Andy Qi & Priyanka S. Narayan. APOE genotypes differentially remodel the astrocytic lipid droplet proteome to shape lipid droplet dynamics.  Nature Communications (2026). https://doi.org/10.1038/s41467-026-76565-6

Thesis: Almudena Maroto Juanes - Disentangling the role of cholesterol in Tauopathies. 

Thesis: Aiko Toda Robert - Metabolism at the crossroads of microglial function and inflammation.

Aiko Robert, Amanda McQuade, Sascha J. Koppes-den Hertog, Lena Erlebach, Deborah Kronenberg-Versteeg, Martin Kampmann, Martin Giera, Rik van der Kant. Comparative lipidomics of iPSC-derived microglia protocols reveal lipid droplet and immune differences mediated by media composition. Stem Cell Reports, 2026 Feb 10;21(2):102779. doi: 10.1016/j.stemcr.2025.102779.

Isha Ralhan, Alison D. Do, Ju-Young Bae, Femke M. Feringa, Wendy Cai, Jinan Chang, Kennedi Chik, Chris Gerry, Rik Van Der Kant, Jesse Jackson, Emily L. Ricq, & Maria S. Ioannou. Protective ApoE variants support neuronal function by extracting peroxidated lipids. Neuron, 2026 Feb 18;114(4):661-678.e10. doi: 10.1016/j.neuron.2025.10.040

Almudena Maroto Juanes, Thomas Vogels, Sascha Koppes-den Herto, Maarten Loos, Dieter Lütjohann, Martin Giera, Rik van der Kant. MAPT P301S mutation and accumulation of pTau distinctly affect the brain lipidome in vivo. JLR, 2026 Jan;67(1):100952. doi: 10.1016/j.jlr.2025.100952

Vromen EM, Lageman SB, Gobom J, van der Kant R, Dobricic V, Bertram L, Streffer J, Lovestone S, Vos SJB, Tainta M, Freund-Levi Y, Frölich L, Popp J, Peyratout G, Tsolaki M, Verhey F, Vandenberghe R, Schaeverbeke J, Blennow K, van der Lee SJ, Scheltens P, Pijnenburg YAL, van der Flier WM, Teunissen CE, Zetterberg H, Visser PJ, Tijms B. Cerebrospinal fluid proteomic associations of APOE genotypes reveal distinct protective and risk mechanisms for Alzheimer's disease. Alzheimers Dementia. 2025 Oct;21(10):e70738. doi: 10.1002/alz.70738.

Pecoraro S, Verkerke M, Sluijs JA, van Het Hof B, van der Pol SMA, van Strien ME, van der Kant R, de Vries C, de Vries HE, van de Berg WDJ, Hol EM, Donega VAdult human subventricular zone microglia promote a pro-neurogenic niche for neuronal progenitors in Parkinson's disease.. Brain Behav Immun. 2025 Jun 16;129:318-334. doi: 10.1016/j.bbi.2025.06.017.

Vromen EM, Lageman SB, Gobom J, van der Kant R, Dobricic V, Bertram L, Streffer J, Lovestone S, Vos SJB, Tainta M, Freund-Levi Y, Frölich L, Popp J, Peyratout G, Tsolaki M, Verhey F, Vandenberghe R, Schaeverbeke J, Blennow K, van der Lee SJ, Scheltens P, Pijnenburg YAL, van der Flier WM, Teunissen CE, Zetterberg H, Visser PJ, Tijms B. Cerebrospinal fluid proteomic associations of APOE genotypes reveal distinct protective and risk mechanisms for Alzheimer's disease. Alzheimers Dementia. 2025 Oct;21(10):e70738. doi: 10.1002/alz.70738.

Feringa FM, Koppes-den Hertog SJ, Wang LY, Derks RJE, Kruijff I, Erlebach L, Heijneman J, Miramontes R, Pömpner N, Blomberg N, Olivier-Jimenez D, Johansen LE, Cammack AJ, Giblin A, Toomey CE, Rose IVL, Yuan H, Ward ME, Isaacs AM, Kampmann M, Kronenberg-Versteeg D, Lashley T, Thompson LM, Ori A, Mohammed Y, Giera M, van der Kant R. The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases. Nature Metabolism 2025 Sep 22. doi: 10.1038/s42255-025-01365-z.

Featured on Alzforum:

https://www.alzforum.org/news/research-news/neurolipid-atlas-links-brain-lipidome-neurodegenerative-disease

and 

https://open.spotify.com/episode/4EMZ95rNBwNNwk93UW6jal?si=7ce203ed2bde4e03

Cuní-López C, Root JT, Hao Y, Kowal I, Blomberg N, Ghirlando R, Yang LG, Koppes-den Hertog SJ, Cookson MR, van der Kant R, Giera M, Qi YA, Narayan PS. APOE genotypes differentially remodel the astrocytic lipid droplet-associated proteome to shape lipid droplet dynamics. bioRxiv [Preprint]. 2025 Aug 20:2025.08.19.669163. doi: 10.1101/2025.08.19.669163.

Isha Ralhan, Alison D. Do, Ju-Young Bae, Femke M. Feringa, Wendy Cai, Jinlan Chang, Kennedi Chik, Nathanael YJ Lee, Chris Gerry, Rik van der Kant, Jesse Jackson, Emily L. Ricq, Maria S. Ioannou. Protective ApoE variants support neuronal function by extracting peroxidated lipids. bioRxiv [preprint]. doi: https://doi.org/10.1101/2025.03.05.641722

Pecoraro S, Verkerke M, Sluijs JA, van Het Hof B, van der Pol SMA, van Strien ME, van der Kant R, de Vries C, de Vries HE, van de Berg WDJ, Hol EM, Donega V. Adult human subventricular zone microglia promote a pro-neurogenic niche for neuronal progenitors in Parkinson's disease. Brain Behav Immun 2025 Oct:129:318-334. doi: 10.1016/j.bbi.2025.06.017.

Giblin A, Cammack AJ, Blomberg N, Anoar S, Mikheenko A, Carcolé M, Atilano ML, Hull A, Shen D, Wei X, Coneys R, Zhou L, Mohammed Y, Olivier-Jimenez D, Wang LY, Kinghorn KJ, Niccoli T, Coyne AN, van der Kant R, Lashley T, Giera M, Partridge L, Isaacs AM.. Neuronal polyunsaturated fatty acids are protective in ALS/FTD. Nature Neuroscience 2025 Apr;28(4):737-747. doi: 10.1038/s41593-025-01889-3

Boyarko B, Podvin S, Greenberg B, Arnold S, Juanes AM, van der Kant R, Goldstein L, Momper JD, Bang A, Silverman J, Feldman HH, Hook V. Challenges and Opportunities for Consideration of Efavirenz Drug Repurposing for Alzheimer's Disease Therapeutics. ACS Pharmacol Transl Sci.  2024 Sep 6;7(10):2924-2935.

Kloske CM, et al. (2024). Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference. Alzheimers Dement. 2024 Sep;20(9):6590-6605. doi: 10.1002/alz.13877.

Feringa, F.M., Van Der Kant, R. An inside job: New roles for ApoE at the lipid droplet. J Cell Biol 2024 Apr 1;223(4):e202402171. 

Kloske CM, Barnum CJ, Batista AF... Carrillo MC (2023). APOE and immunity: Research highlights. Alzheimers Dementia. 2023 Jun;19(6):2677-2696

Mishra, S., Van Deursen, C., Robert, A., Van Der Kant, R., & Young, J. E. (2023). Advantages and limitations of hiPSC-derived neurons for the study of neurodegeneration. In Phenotyping of Human iPSC-derived Neurons (pp. 243-261). Academic Press. 

Pantazis, C. B., Yang, A., Lara, E., McDonough, J. A., Blauwendraat, C., Peng, L., ... & Merkle, F. T. (2022). A reference human induced pluripotent stem cell line for large-scale collaborative studies. Cell Stem Cell, 29(12), 1685-1702. 

Ossenkoppele, R., van der Kant, R., & Hansson, O. (2022). Tau biomarkers in Alzheimer's disease: towards implementation in clinical practice and trials. The Lancet Neurology. 

Frisoni, G. B., Altomare, D., Thal, D. R., Ribaldi, F., van der Kant, R., Ossenkoppele, R., ... & Dubois, B. (2022). The probabilistic model of Alzheimer disease: the amyloid hypothesis revised. Nature Reviews Neuroscience, 23(1), 53-66. 

Feringa, F. M., & Van der Kant, R. (2021). Cholesterol and Alzheimer’s disease; from risk genes to pathological effects. Frontiers in Aging Neuroscience, 13, 690372. 

Langness, V. F., Van der Kant, R., Das, U., Wang, L., Chaves, R. D. S., & Goldstein, L. S. (2021). Cholesterol-lowering drugs reduce APP processing to Aβ by inducing APP dimerization. Molecular Biology of the Cell, 32(3), 247-259. 

Jongsma, M. L., Bakker, J., Cabukusta, B., Liv, N., van Elsland, D., Fermie, J., ... & Neefjes, J. (2020). SKIP‐HOPS recruits TBC 1D15 for a Rab7‐to‐Arl8b identity switch to control late endosome transport. The EMBO journal, 39(6), e102301. 

van der Kant, R., Goldstein, L. S., & Ossenkoppele, R. (2020). Amyloid-β-independent regulators of tau pathology in Alzheimer disease. Nature Reviews Neuroscience, 21(1), 21-35. 

van der Kant, R., Langness, V. F., Herrera, C. M., Williams, D. A., Fong, L. K., Leestemaker, Y., ... & Goldstein, L. S. (2019). Cholesterol metabolism is a druggable axis that independently regulates tau and amyloid-β in iPSC-derived Alzheimer’s disease neurons. Cell stem cell, 24(3), 363-375. 

In the news:

https://www.alzforum.org/news/research-news/cholesteryl-esters-hobble-proteasomes-increase-p-tau (Alzforum post)
https://pubmed.ncbi.nlm.nih.gov/30849361/ (News and Views)

https://www.telegraaf.nl/nieuws/3152727/cholesterolremmers-helpen-tegen-alzheimer (Dutch news outlet)
https://www.rtlnieuws.nl/nieuws/nederland/artikel/4609246/mogelijk-verband-tussen-cholesterol-en-alzheimer  (Dutch news outlet)

Woodruff, G., Reyna, S. M., Dunlap, M., Van Der Kant, R., Callender, J. A., Young, J. E., ... & Goldstein, L. S. (2016). Defective transcytosis of APP and lipoproteins in human iPSC-derived neurons with familial Alzheimer’s disease mutations. Cell reports, 17(3), 759-773. 

Van Der Kant, R., Jonker, C. T., Wijdeven, R. H., Bakker, J., Janssen, L., Klumperman, J., & Neefjes, J. (2015). Characterization of the mammalian CORVET and HOPS complexes and their modular restructuring for endosome specificity. Journal of Biological Chemistry, 290(51), 30280-30290. 

Van Der Kant, R., & Goldstein, L. S. (2015). Cellular functions of the amyloid precursor protein from development to dementia. Developmental cell, 32(4), 502-515. 

van der Kant, R., & Neefjes, J. (2014). Small regulators, major consequences–Ca2+ and cholesterol at the endosome–ER interface. Journal of cell science, 127(5), 929-938. 

Neefjes, J., & van der Kant, R. (2014). Stuck in traffic: an emerging theme in diseases of the nervous system. Trends in neurosciences, 37(2), 66-76. 

van der Kant, R., Fish, A., Janssen, L., Janssen, H., Krom, S., Ho, N., ... & Neefjes, J. (2013). Late endosomal transport and tethering are coupled processes controlled by RILP and the cholesterol sensor ORP1L. Journal of cell science, 126(15), 3462-3474.